The ERK signaling cascade--views from different subcellular compartments (Q24309261)

Mitogen-activated protein kinase kinase 1

Europe PubMed Central

title

The ERK signaling cascade--views from different subcellular compartments (English)

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main subject

clinical chemistry

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Mitogen-activated protein kinase kinase 2

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ERT2

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mitogen-activated protein kinase 1

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regulation of early endosome to late endosome transport

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Mitogen-activated protein kinase 3

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Mitogen-activated protein kinase 1

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Mitogen-activated protein kinase kinase 2

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Mitogen-activated protein kinase kinase 1

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KSR, a novel protein kinase required for RAS signal transduction

author name string

Zhong Yao

series ordinal

1

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Rony Seger

series ordinal

2

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language of work or name

English

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publication date

2009

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35

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page(s)

407-16

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issue

5

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cites work

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7 January 2021

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

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7 January 2021

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

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7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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7 January 2021

The MEK/ERK cascade: from signaling specificity to diverse functions

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7 January 2021

Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo

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7 January 2021

Sef is a spatial regulator for Ras/MAP kinase signaling.

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7 January 2021

Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis

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7 January 2021

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

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7 January 2021

DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation.

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7 January 2021

Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes

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7 January 2021

Identification and characterization of a general nuclear translocation signal in signaling proteins

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7 January 2021

Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve

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7 January 2021

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

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7 January 2021

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

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7 January 2021

Bcl-2 targets the protein kinase Raf-1 to mitochondria

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7 January 2021

CNK, a RAF-binding multidomain protein required for RAS signaling

1 reference

7 January 2021

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

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7 January 2021

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

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7 January 2021

Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

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7 January 2021

A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation

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7 January 2021

Docking domains and substrate-specificity determination for MAP kinases

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7 January 2021

Activated MEK1 binds the nuclear MyoD transcriptional complex to repress transactivation

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7 January 2021

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

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7 January 2021

Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis

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7 January 2021

Spatio-temporal images of growth-factor-induced activation of Ras and Rap1.

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7 January 2021

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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7 January 2021

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

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7 January 2021

Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2

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7 January 2021

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

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7 January 2021

Sensing the environment: a historical perspective on integrin signal transduction

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7 January 2021

The RAF proteins take centre stage

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7 January 2021

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

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7 January 2021

The RSK family of kinases: emerging roles in cellular signalling

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7 January 2021

Non-regulated and stimulated mechanisms cooperate in the nuclear accumulation of MEK1.

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7 January 2021

Signalling to translation: how signal transduction pathways control the protein synthetic machinery

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7 January 2021

Extracellular regulated kinase (ERK) interaction with actin and the calponin homology (CH) domain of actin-binding proteins.

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7 January 2021

Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists

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7 January 2021

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

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7 January 2021

Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

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7 January 2021

IQGAP1 modulates activation of B-Raf

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7 January 2021

Spatial regulation of Raf kinase signaling by RKTG

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7 January 2021

Association of mitogen-activated protein kinase with the microtubule cytoskeleton

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7 January 2021

Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors

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7 January 2021

Identification of a cytoplasmic-retention sequence in ERK2

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7 January 2021

Involvement of the activation loop of ERK in the detachment from cytosolic anchoring

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7 January 2021

ERK1 associates with alpha(v)beta 3 integrin and regulates cell spreading on vitronectin

1 reference

7 January 2021

Constitutive localization of the gonadotropin-releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK.

1 reference

7 January 2021

PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation

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7 January 2021

Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells.

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7 January 2021

p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association

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7 January 2021

B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding

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7 January 2021

Mutations in ERK2 Binding Sites Affect Nuclear Entry

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7 January 2021

Calcium-mediated interactions regulate the subcellular localization of extracellular signal-regulated kinases

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7 January 2021

Isoform-specific interaction of C-RAF with mitochondria

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7 January 2021

ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK

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7 January 2021

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

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7 January 2021

Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism

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7 January 2021

A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment

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7 January 2021

Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1

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7 January 2021

Regulation of Ras-MAPK pathway mitogenic activity by restricting nuclear entry of activated MAPK in endoderm differentiation of embryonic carcinoma and stem cells

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7 January 2021

p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis

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7 January 2021

Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer.

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7 January 2021

Regulation of Raf-1 activation and signalling by dephosphorylation

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7 January 2021

Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain development.

1 reference

7 January 2021

RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility

1 reference

7 January 2021

Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma

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7 January 2021

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

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7 January 2021

Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation

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7 January 2021

Isoform-specific localization of A-RAF in mitochondria

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7 January 2021

Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2.

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7 January 2021

Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function

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7 January 2021

Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor.

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7 January 2021

Regulation and role of Raf-1/B-Raf heterodimerization

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7 January 2021

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

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7 January 2021

Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton

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7 January 2021

Protein-protein interactions in the regulation of the extracellular signal-regulated kinase

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7 January 2021