The role of signaling pathways in the development and treatment of hepatocellular carcinoma (Q37773788)

22 August 2017

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title

The role of signaling pathways in the development and treatment of hepatocellular carcinoma (English)

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22 August 2017

1

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22 August 2017

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22 August 2017

A X Zhu

3

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PubMed ID

20639898

22 August 2017

language of work or name

English

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publication date

19 July 2010

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22 August 2017

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22 August 2017

29

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22 August 2017

4989-5005

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22 August 2017

36

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https://scigraph.springernature.com/pub.10.1038/onc.2010.236

22 August 2017

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

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New aspects of an anti-tumour drug: sorafenib efficiently inhibits HCV replication

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Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells

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31 March 2020

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Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma

31 March 2020

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31 March 2020

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Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma

31 March 2020

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Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

31 March 2020

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Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

31 March 2020

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Expression of transforming growth factor alpha and epidermal growth factor receptor in human hepatocellular carcinoma

31 March 2020

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Sirolimus-based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma

31 March 2020

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

31 March 2020

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PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

31 March 2020

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Raf kinases: function, regulation and role in human cancer

31 March 2020

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Hepatitis B x antigen up-regulates vascular endothelial growth factor receptor 3 in hepatocarcinogenesis

31 March 2020

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Sorafenib is a potent inhibitor of FIP1L1-PDGFRalpha and the imatinib-resistant FIP1L1-PDGFRalpha T674I mutant

31 March 2020

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Both antiangiogenesis- and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584.

31 March 2020

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Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation

31 March 2020

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Sorafenib in advanced hepatocellular carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Autocrine inhibition of chemotherapy response in human liver tumor cells by insulin-like growth factor-II.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.236

Angiogenesis soluble factors as hepatocellular carcinoma noninvasive markers for monitoring hepatitis C virus cirrhotic patients awaiting liver transplantation.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Emerging multipotent aspects of hepatocyte growth factor

31 March 2020

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Induction of the estrogen receptor by ablation of DNMT1 in ER-negative breast cancer cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Management of hepatocellular cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Microvessel density, vascular endothelial growth factor and its receptors Flt-1 and Flk-1/KDR in hepatocellular carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Gefitinib and the modulation of the signaling pathways downstream of epidermal growth factor receptor in human liver cancer cells.

31 March 2020

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Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis

31 March 2020

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Mechanisms of normal and tumor-derived angiogenesis

31 March 2020

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Global cancer statistics, 2002

31 March 2020

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Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer

31 March 2020

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Insulin-like growth factors and neoplasia.

31 March 2020

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Bone marrow stromal cells as a genetic platform for systemic delivery of therapeutic proteins in vivo: human factor IX model

31 March 2020

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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

31 March 2020

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Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma

31 March 2020

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Hepatocellular carcinoma: molecular pathways and new therapeutic targets.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Emerging drugs for hepatocellular carcinoma.

31 March 2020

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mTOR and P70 S6 kinase expression in primary liver neoplasms

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: interactions between Erk-1/2 and Elk-1

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis

31 March 2020

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Cell signaling by receptor tyrosine kinases

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection

31 March 2020

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Analysis of the transcriptional program induced by Raf in epithelial cells

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Angiogenesis and hepatocellular carcinoma

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Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma

31 March 2020

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Detection of vascular endothelial growth factor and its receptor expression in human hepatocellular carcinoma biopsy specimens

31 March 2020

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Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma

31 March 2020

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Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation

31 March 2020

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Treatment of hepatocellular carcinoma: a systematic review of randomized controlled trials

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Integrity of c-Raf-1/MEK signal transduction cascade is essential for hepatitis B virus gene expression

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

CD24 expression is a prognostic factor in intrahepatic cholangiocarcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Expression of the c-met protooncogene in human hepatocellular carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

u-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Opportunities for targeted therapies in hepatocellular carcinoma

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Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma

31 March 2020

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Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma.

31 March 2020

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Molecular pathogenesis of human hepatocellular carcinoma

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Crosstalk between Pten and Ras signaling pathways in tumor development.

31 March 2020

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PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Expression of hepatocyte growth factor and its receptor, the c-met proto-oncogene, in hepatocellular carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Pivotal role of mTOR signaling in hepatocellular carcinoma

31 March 2020

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Genomics and signaling pathways in hepatocellular carcinoma.

31 March 2020

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Molecular pathogenesis of human hepatocellular carcinoma.

31 March 2020

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Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma

31 March 2020

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AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer

31 March 2020

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Gatekeeper mutations mediate resistance to BRAF-targeted therapies.

31 March 2020

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Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.

31 March 2020

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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Molecular mechanisms involved in macrophage survival, proliferation, activation or apoptosis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Expression of vascular endothelial growth factor in human hepatocellular carcinoma.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Effect of blocking IGF-I receptor on growth of human hepatocellular carcinoma cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Expression of platelet-derived endothelial cell growth factor and vascular endothelial growth factor in hepatocellular carcinoma and portal vein tumor thrombus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.236

Systemic therapy of advanced hepatocellular carcinoma: how hopeful should we be?

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Development of sorafenib and other molecularly targeted agents in hepatocellular carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.236

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.236

1 reference

22 August 2017

1 reference

PubMed ID

20639898