Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes (Q37760961)

22 August 2017

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title

Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes (English)

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22 August 2017

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Kathleen G Mountjoy

1

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PubMed ID

20504281

22 August 2017

language of work or name

English

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publication date

27 May 2010

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22 August 2017

20

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based on heuristic

inferred from page(s)

published in

Biochemical Journal

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22 August 2017

428

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22 August 2017

3

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22 August 2017

305-324

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Obesity, diabetes and functions for proopiomelanocortin-derived peptides

22 August 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Studies on the physiological functions of the melanocortin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Creation of a genetic model of obesity in a teleost.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Neuropeptide processing and its impact on melanocortin pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Proopiomelanocortin gene is expressed in many normal human tissues and in tumors not associated with ectopic adrenocorticotropin syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

ACTH-(1-24) and alpha-MSH antagonize feeding behavior stimulated by kappa opiate agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Investigation of the melanocyte stimulating hormones on food intake. Lack Of evidence to support a role for the melanocortin-3-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin-4 receptors, beta-MSH and leptin: key elements in the satiety pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Differential effects of alpha-, beta- and gamma(2)-melanocyte-stimulating hormones on hypothalamic neuronal activation and feeding in the fasted rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Effects of MSH on food intake, body weight and coat color of the yellow obese mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Minireview. Peptides and the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Distribution of radioactivity in the organs of the rat and mouse after injection of (125I)alpha-melanocyte-stimulating hormone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Acetylation alters the feeding response to MSH and beta-endorphin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

alpha-MSH and desacetyl-alpha-MSH signaling through melanocortin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Prenatal processing of pro-opiomelanocortin in the brain and pituitary of mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Regional heterogeneity in the processing of pro-opiomelanocortin in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Characterization of alpha-MSH-related peptides released from rat hypothalamic neurons in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Localisation and identification of melanocyte-stimulating hormones in the fish brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Characterization of the forms of beta-endorphin and alpha-MSH in the caudal medulla of the rat and guinea pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Coordinate regulation of peptide acetyltransferase activity and proopiomelanocortin gene expression in the intermediate lobe of the rat pituitary.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

GABA and dopamine act directly on melanotropes of Xenopus to inhibit MSH secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Differential release of alpha-melanophore stimulating hormone isoforms by the pituitary gland of red porgy, Pagrus pagrus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Dopamine is required for hyperphagia in Lep(ob/ob) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Neuropeptide Y, alpha-melanocyte-stimulating hormone, and monoamines in food intake regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Hypothalamic alpha-melanocyte-stimulating hormone (alpha-MSH) is not under dopaminergic control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A Role for the Endogenous Opioid β-Endorphin in Energy Homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Proopiomelanocortin (POMC) products in the central regulation of sympathetic and cardiovascular dynamics: studies on melanocortin and opioid interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

C-terminal fragments of ACTH stimulate feeding in fasted rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Lack of proopiomelanocortin peptides results in obesity and defective adrenal function but normal melanocyte pigmentation in the murine C57BL/6 genetic background

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A comparative study of the central effects of specific proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in pomc null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Altered glucose homeostasis in proopiomelanocortin-null mouse mutants lacking central and peripheral melanocortin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Mutational analysis of evolutionarily conserved ACTH residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Implications of proopiomelanocortin (POMC) mutations in humans: the POMC deficiency syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Energy balance pathways converging on the Nhlh2 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Altered biosynthesis and secretion of pro-opiomelanocortin in the intermediate and anterior pituitary of carboxypeptidase E-deficient, Cpe(fat)/ Cpe(fat)mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The Central Melanocortin System and Energy Homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The central melanocortin system directly controls peripheral lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Genetic dissection of neuronal pathways controlling energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in C57BL/6J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Functional characterization of mutations in melanocortin-4 receptor associated with human obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Poor Cell Surface Expression of Human Melanocortin-4 Receptor Mutations Associated with Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The human MC4R promoter: characterization and role in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Several mutations in the melanocortin 4 receptor gene are associated with obesity in Chinese children and adolescents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with early-onset obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Identification and functional characterization of three novel human melanocortin-4 receptor gene variants in an obese Chinese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A role for beta-melanocyte-stimulating hormone in human body-weight regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin-4 receptor gene variant I103 is negatively associated with obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin-3 receptor gene variants in a Maori kindred with obesity and early onset type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A polymorphism (D20S32e) close to the human melanocortin receptor 3 is associated with insulin resistance but not the metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Characterization of mice deficient in melanocortin 2 receptor on a B6/Balbc mix background

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Mechanisms of disease: the adrenocorticotropin receptor and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Skin colour and skin cancer - MC1R, the genetic link

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Divergence of melanocortin pathways in the control of food intake and energy expenditure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Identification of nesfatin-1 as a satiety molecule in the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Reversal of Behavioral and Metabolic Abnormalities, and Insulin Resistance Syndrome, by Dietary Restriction in Mice Deficient in Brain-Derived Neurotrophic Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling is a downstream effector of the brainstem melanocortin system in food intake control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin-4 receptor mRNA expression in the developing autonomic and central nervous systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Energetic responses are triggered by caudal brainstem melanocortin receptor stimulation and mediated by local sympathetic effector circuits

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin receptors mediate the excitatory effects of blood-borne murine leptin on hypothalamic paraventricular neurons in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The role of the vgf gene and VGF-derived peptides in nutrition and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The melanocortin-3 receptor is required for entrainment to meal intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The melanocortin system and energy balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Circadian rhythms: perturbing a food-entrained clock

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Differential regulation of the expression of Period2 protein in the limbic forebrain and dorsomedial hypothalamus by daily limited access to highly palatable food in food-deprived and free-fed rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Elevated arylalkylamine-N-acetyltransferase (AA-NAT) gene expression in medial habenular and suprachiasmatic nuclei of hibernating ground squirrels

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Photoperiod regulates genes encoding melanocortin 3 and serotonin receptors and secretogranins in the dorsomedial posterior arcuate of the Siberian hamster

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Effects of pro-opiomelanocortin (POMC) on food intake and body weight: mechanisms and therapeutic potential?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Neurochemical phenotype of hypothalamic neurons showing Fos expression 23 h after intracranial AgRP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Leptin amplifies the feeding inhibition and neural activation arising from a gastric nutrient preload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Characterization of leptin-responsive neurons in the caudal brainstem.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tract.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Leptin-dependent control of glucose balance and locomotor activity by POMC neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Hypothalamic control of energy balance: different peptides, different functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Central insulin enhances sensitivity to cholecystokinin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Hormone and glucose signalling in POMC and AgRP neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Central nervous system control of food intake and body weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

mTOR tells the brain that the body is hungry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Enterostatin inhibition of dietary fat intake is modulated through the melanocortin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Vagal-central nervous system interactions modulate the feeding response to peripheral enterostatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Enterostatin increases extracellular serotonin and dopamine in the lateral hypothalamic area in rats measured by in vivo microdialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The use of melanocortin antagonists in cachexia of chronic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Mechanisms of obesity and related pathology: linking immune responses to metabolic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Stress, visceral obesity, and metabolic complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Hypothalamic-Pituitary Cytokine Network

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Central LIF gene therapy suppresses food intake, body weight, serum leptin and insulin for extended periods

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Interleukin-18 and stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Tissue-specific expression of rat IL-18 gene and response to adrenocorticotropic hormone treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Cell-specific pituitary gene expression profiles after treatment with leukemia inhibitory factor reveal novel modulators for proopiomelanocortin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Neuronal activation in the hypothalamus and brainstem during feeding in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The brain is getting ready for dinner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Hypothalamic sensing of fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Modern medical management of obesity: the role of pharmaceutical intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Evidence for direct actions of melanocortin peptides on bone metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin-4 receptor messenger ribonucleic acid expression in rat cardiorespiratory, musculoskeletal, and integumentary systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Regulation of adipose tissue leptin secretion by alpha-melanocyte-stimulating hormone and agouti-related protein: further evidence of an interaction between leptin and the melanocortin signalling system

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Spatial and temporal patterns of expression of melanocortin type 2 and 5 receptors in the fetal mouse tissues and organs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A derivative of the melanocortin receptor antagonist SHU9119 (PG932) increases food intake when administered peripherally

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The central melanocortin system can directly regulate serum insulin levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Central melanocortin receptors regulate insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Obesity and the Metabolic Syndrome: implications for dietetics practitioners

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

ACTH and alpha-MSH inhibit leptin expression and secretion in 3T3-L1 adipocytes: model for a central-peripheral melanocortin-leptin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Peripherally administered [Nle4,D-Phe7]-alpha-melanocyte stimulating hormone increases resting metabolic rate, while peripheral agouti-related protein has no effect, in wild type C57BL/6 and ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A peroxisome proliferator-response element in the murine mc2-r promoter regulates its transcriptional activation during differentiation of 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Chemical and biological characterization of salmon melanocyte-stimulating hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Agouti expression in human adipose tissue: functional consequences and increased expression in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin crosstalk with adipose functions: ACTH directly induces insulin resistance, promotes a pro-inflammatory adipokine profile and stimulates UCP-1 in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Drug target discovery by pharmacogenetics: mutations in the melanocortin system and eating disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

The obesity pipeline: current strategies in the development of anti-obesity drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

A -defensin mutation causes black coat color in domestic dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin-4-receptor autoantibodies: a new player in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Autoantibodies against alpha -MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Autoantibodies against neuropeptides are associated with psychological traits in eating disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Obesity and diabetes in transgenic mice expressing proSAAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Prevalence of Mutations and Functional Analyses of Melanocortin 4 Receptor Variants Identified among 750 Men with Juvenile-Onset Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Melanocortin-4 Receptor Activation Stimulates Hypothalamic Brain-Derived Neurotrophic Factor Release to Regulate Food Intake, Body Temperature and Cardiovascular Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091957

21 January 2018

Identifiers

DOI

10.1042/BJ20091957

1 reference

22 August 2017

1 reference

PubMed ID

20504281