MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes (Q37694711)

22 August 2017

MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes (English)

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22 August 2017

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Zahra Azizi

3

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François Pattou

object named as

Francois Pattou

10

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Kathrin Maedler

object named as

Kathrin Maedler

12

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author name string

Amin Ardestani

1

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22 August 2017

Federico Paroni

2

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22 August 2017

Supreet Kaur

4

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22 August 2017

Vrushali Khobragade

5

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22 August 2017

Ting Yuan

6

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22 August 2017

Thomas Frogne

7

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22 August 2017

Wufan Tao

8

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22 August 2017

Jose Oberholzer

9

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22 August 2017

Julie Kerr Conte

11

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22 August 2017

language of work or name

English

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publication date

16 March 2014

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22 August 2017

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22 August 2017

20

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22 August 2017

4

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22 August 2017

385-397

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https://scigraph.springernature.com/pub.10.1038/nm.3482

22 August 2017

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cites work

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Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance.

23 August 2017

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Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation

23 August 2017

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GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus

23 August 2017

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GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes

23 August 2017

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Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling

23 August 2017

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Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization

23 August 2017

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β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency

23 August 2017

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Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice

23 August 2017

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Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta?

23 August 2017

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Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

23 August 2017

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c-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82

23 August 2017

1 reference

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Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice

23 August 2017

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Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120

23 August 2017

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Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases

23 August 2017

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The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways

23 August 2017

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Transfection of rat pancreatic islet tissue by polymeric gene vectors

23 August 2017

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Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

23 August 2017

1 reference

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Linear Motif Atlas for Phosphorylation-Dependent Signaling

23 August 2017

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Apoptosis-associated mitochondrial outer membrane permeabilization assays

23 August 2017

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Biosignaling of mammalian Ste20-related kinases

23 August 2017

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The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia

23 August 2017

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RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

23 August 2017

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The replication of beta cells in normal physiology, in disease and for therapy

23 August 2017

1 reference

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The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1

23 August 2017

1 reference

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RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

23 August 2017

1 reference

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The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications

23 August 2017

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Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

23 August 2017

1 reference

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Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase

23 August 2017

1 reference

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Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy

23 August 2017

1 reference

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Apoptosis in the development and maintenance of the immune system

23 August 2017

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Increased islet apoptosis in Pdx1+/- mice

23 August 2017

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JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

23 August 2017

1 reference

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

23 August 2017

1 reference

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Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis

23 August 2017

1 reference

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beta-Cell death during progression to diabetes

23 August 2017

1 reference

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Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Beta cell apoptosis in T cell-mediated autoimmune diabetes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Insulin-promoter-factor 1 is required for pancreas development in mice

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Integrative mitogenic role of protein kinase B/Akt in beta-cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Diet-induced type II diabetes in C57BL/6J mice

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

A cell-intrinsic role for Mst1 in regulating thymocyte egress.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Strategies for protein coexpression in Escherichia coli

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Type 2 diabetes-a matter of beta-cell life and death?

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981675

Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus

1 September 2018

1 reference

12 December 2020

TCF7L2 promotes beta cell regeneration in human and mouse pancreas

1 reference

12 December 2020

Islet loss and alpha cell expansion in type 1 diabetes induced by multiple low-dose streptozotocin administration in mice

1 reference

12 December 2020

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

1 reference

12 December 2020

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

1 reference

12 December 2020

Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial. The Diabetes Control and Complications Trial Research Group

1 reference

12 December 2020

Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis

1 reference

12 December 2020

Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.3482

1 reference

release_elugf4md7vadxkt63hzwlgvfyy

22 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/elugf4md7vadxkt63hzwlgvfyy

24 November 2022

mapped directly with Wikidata item

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22 August 2017

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