Emerging roles of deubiquitinases in cancer-associated pathways (Q37674364)

21 August 2017

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title

Emerging roles of deubiquitinases in cancer-associated pathways (English)

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21 August 2017

Sylvie Urbé

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Michael J. Clague

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Michael J Clague

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Judy M Coulson

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Judy M Coulson

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author name string

Joseph J Sacco

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21 August 2017

1 February 2010

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21 August 2017

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21 August 2017

62

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21 August 2017

2

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21 August 2017

140-157

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Metastatic potential of an aneurysmal bone cyst

21 August 2017

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Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.

21 January 2018

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PGP9.5 as a candidate tumor marker for non-small-cell lung cancer

21 January 2018

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ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation

21 January 2018

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Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells

21 January 2018

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PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers

21 January 2018

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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12 December 2020

The Catalogue of Somatic Mutations in Cancer (COSMIC)

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12 December 2020

USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst

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12 December 2020

Endocytosis: the DUB version

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12 December 2020

Serial analysis of gene expression in non-small cell lung cancer

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12 December 2020

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

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12 December 2020

Deubiquitination of FANCD2 is required for DNA crosslink repair

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12 December 2020

Ubiquitin and ubiquitin-like proteins as multifunctional signals

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12 December 2020

Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling

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12 December 2020

The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines

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12 December 2020

The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another

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12 December 2020

Ubiquitin in NF-kappaB signaling.

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12 December 2020

Midline crossing and Slit responsiveness of commissural axons require USP33

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12 December 2020

Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads

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12 December 2020

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

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12 December 2020

Familial cylindromatosis (turban tumour syndrome) gene localised to chromosome 16q12-q13: evidence for its role as a tumour suppressor gene

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12 December 2020

Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors

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12 December 2020

USP11 stabilizes HPV-16E7 and further modulates the E7 biological activity

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12 December 2020

USP15 plays an essential role for caspase-3 activation during Paclitaxel-induced apoptosis

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12 December 2020

Reflecting on 25 years with MYC.

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12 December 2020

Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53

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12 December 2020

The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin

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12 December 2020

The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin

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12 December 2020

Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation

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12 December 2020

OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity

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12 December 2020

Wnt/beta-catenin signaling: components, mechanisms, and diseases

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12 December 2020

Molecular cloning of a novel oncogene generated by DNA recombination during transfection

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12 December 2020

The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.

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12 December 2020

TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma.

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12 December 2020

Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

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12 December 2020

Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells.

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12 December 2020

Regulation of ErbB2 receptor status by the proteasomal DUB POH1.

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12 December 2020

Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

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12 December 2020

Current perspective - trastuzumab

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12 December 2020

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

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12 December 2020

BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage

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12 December 2020

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

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12 December 2020

The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition

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12 December 2020

A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes

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12 December 2020

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo

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12 December 2020

UBPY-mediated epidermal growth factor receptor (EGFR) de-ubiquitination promotes EGFR degradation

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12 December 2020

PGP9.5 overexpression in esophageal squamous cell carcinoma

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12 December 2020

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

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12 December 2020

Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.

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12 December 2020

Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease

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12 December 2020

NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway

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12 December 2020

The Fanconi anemia pathway and ubiquitin

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12 December 2020

Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors.

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12 December 2020

The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability

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12 December 2020

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

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12 December 2020

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

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12 December 2020

Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles

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12 December 2020

Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer

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12 December 2020

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

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12 December 2020

The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways

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12 December 2020

RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis

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12 December 2020

The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway

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12 December 2020

Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes

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12 December 2020

Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells

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12 December 2020

Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.

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12 December 2020

Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation

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12 December 2020

Breaking the chains: structure and function of the deubiquitinases

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12 December 2020

Human USP3 is a chromatin modifier required for S phase progression and genome stability

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12 December 2020

Mohs surgical extirpation of a basal cell carcinoma in a patient with familial multiple trichoepitheliomas

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12 December 2020

TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas

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12 December 2020

The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.

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12 December 2020

Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling

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12 December 2020

UBP43 (USP18) specifically removes ISG15 from conjugated proteins

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12 December 2020

Ubiquitin and endocytic protein sorting

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12 December 2020

The isopeptidase USP2a protects human prostate cancer from apoptosis

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12 December 2020

Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control.

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12 December 2020

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

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12 December 2020

[Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues].

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12 December 2020

Expression profiling of adrenocortical neoplasms suggests a molecular signature of malignancy

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12 December 2020

The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling

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12 December 2020

Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer.

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12 December 2020

The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.

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12 December 2020

The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.

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12 December 2020

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

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12 December 2020

The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration.

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12 December 2020

PGP9.5 methylation as a marker for metastatic colorectal cancer

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12 December 2020

Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction

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12 December 2020

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

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12 December 2020

Molecular Basis for the Unique Deubiquitinating Activity of the NF-κB Inhibitor A20

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12 December 2020

Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling

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12 December 2020

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

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12 December 2020

A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia.

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12 December 2020

CpG island hypermethylation in progression of esophageal and gastric cancer

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12 December 2020

Frequent inactivation of A20 in B-cell lymphomas

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12 December 2020

Kinetic and mechanistic studies on the hydrolysis of ubiquitin C-terminal 7-amido-4-methylcoumarin by deubiquitinating enzymes

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12 December 2020

The nuclear affairs of PTEN.

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12 December 2020

Differential expression and function of A20 and TRAF1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD30 stimulation

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12 December 2020

Tumor suppressor CYLD: negative regulation of NF-kappaB signaling and more

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12 December 2020

Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics

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12 December 2020

Drug Insight: gastrointestinal stromal tumors (GIST)--the solid tumor model for cancer-specific treatment

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12 December 2020

Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling

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12 December 2020

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

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12 December 2020

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

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12 December 2020

Structural basis for the specificity of ubiquitin C-terminal hydrolases

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12 December 2020

Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

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12 December 2020

Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome

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12 December 2020

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

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12 December 2020

The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation

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12 December 2020

Ubiquitin-binding domains - from structures to functions

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12 December 2020

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

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12 December 2020

The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling

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12 December 2020

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

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12 December 2020

A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents

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12 December 2020

Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis

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12 December 2020

PGP9.5 as a marker for invasive colorectal cancer

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12 December 2020

Regulation of monoubiquitinated PCNA by DUB autocleavage

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12 December 2020

Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.

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12 December 2020

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

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12 December 2020

CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes

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12 December 2020

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

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12 December 2020

Cutaneous cylindroma with malignant transformation

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12 December 2020

CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha

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12 December 2020

USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity

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12 December 2020

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

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12 December 2020

Reduced expression of CYLD in human colon and hepatocellular carcinomas

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12 December 2020

PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma

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12 December 2020

The tumor suppressor CYLD regulates entry into mitosis

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12 December 2020

p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1.

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12 December 2020

The c-Myc target gene network

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12 December 2020

Deubiquitinase activities required for hepatocyte growth factor-induced scattering of epithelial cells

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12 December 2020

The many ways of Wnt in cancer

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12 December 2020

A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation

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12 December 2020

The Wnt signaling pathway in development and disease

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12 December 2020

Derailed endocytosis: an emerging feature of cancer

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12 December 2020

HAUSP is required for p53 destabilization

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12 December 2020

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

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12 December 2020

Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation

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12 December 2020

Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases

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12 December 2020

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

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12 December 2020

The myc oncogene: MarvelouslY Complex

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12 December 2020

The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein

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12 December 2020

The 19 S proteasomal subunit POH1 contributes to the regulation of c-Jun ubiquitination, stability, and subcellular localization

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12 December 2020

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

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12 December 2020

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

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12 December 2020

Targeting ubiquitin specific proteases for drug discovery

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12 December 2020

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

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12 December 2020

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

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12 December 2020

AMSH is an endosome-associated ubiquitin isopeptidase

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12 December 2020

Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration

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12 December 2020

The ubiquitin-specific protease USP28 is required for MYC stability

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12 December 2020

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing

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12 December 2020

USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.

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12 December 2020

Structure of the A20 OTU domain and mechanistic insights into deubiquitination

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12 December 2020

A substrate for deubiquitinating enzymes based on time-resolved fluorescence resonance energy transfer between terbium and yellow fluorescent protein.

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12 December 2020

The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation

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12 December 2020

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

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12 December 2020

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

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12 December 2020

The Unp proto-oncogene encodes a nuclear protein.

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12 December 2020

The emerging genetic and molecular basis of Fanconi anaemia

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12 December 2020

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

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12 December 2020

A20 deletion is associated with copy number gain at the TNFA/B/C locus and occurs preferentially in translocation-negative MALT lymphoma of the ocular adnexa and salivary glands.

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12 December 2020

NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling

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12 December 2020

Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells

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12 December 2020

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

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12 December 2020

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer.

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12 December 2020

Differential expression profiling of genes in a complete hydatidiform mole using cDNA microarray analysis

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12 December 2020

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

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12 December 2020

Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations.

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12 December 2020

Deubiquitylation and regulation of the immune response

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12 December 2020

The genomic landscapes of human breast and colorectal cancers

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12 December 2020

Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3-3p21.3 in sporadic breast-cancer development

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12 December 2020

Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery

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12 December 2020

VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha

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12 December 2020

Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII

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12 December 2020

Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.

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12 December 2020

Comparative proteomic analysis of osteosarcoma cell and human primary cultured osteoblastic cell

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12 December 2020

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.

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12 December 2020

PGP9.5 as a prognostic factor in pancreatic cancer

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12 December 2020

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

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12 December 2020

Identifiers

DOI

10.1002/IUB.300

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21 August 2017

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PubMed ID

20073038