mTOR function in skeletal muscle: a focal point for overnutrition and exercise (Q37638216)

21 August 2017

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title

mTOR function in skeletal muscle: a focal point for overnutrition and exercise (English)

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21 August 2017

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Donato A Rivas

1

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PubMed ID

19935842

21 August 2017

Sarah J Lessard

series ordinal

2

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PubMed ID

19935842

21 August 2017

Vernon G Coffey

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3

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21 August 2017

1 October 2009

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Applied Physiology, Nutrition, and Metabolism

21 August 2017

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21 August 2017

34

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21 August 2017

807-816

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21 August 2017

5

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Divergent cell signaling after short-term intensified endurance training in human skeletal muscle

21 August 2017

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Rapamycin partially prevents insulin resistance induced by chronic insulin treatment

21 January 2018

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Translational control of localized mRNAs: restricting protein synthesis in space and time

21 January 2018

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21 January 2018

The two TORCs and Akt.

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Insulin signal transduction in human skeletal muscle: identifying the defects in Type II diabetes

21 January 2018

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Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle

21 January 2018

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siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

21 January 2018

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A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

21 January 2018

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Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus

21 January 2018

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The molecular bases of training adaptation

21 January 2018

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Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle

21 January 2018

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Tissue-specific regulation of protein synthesis by insulin and free fatty acids

21 January 2018

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Mammalian TOR: a homeostatic ATP sensor

21 January 2018

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Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

21 January 2018

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Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle.

21 January 2018

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Resistance exercise increases human skeletal muscle AS160/TBC1D4 phosphorylation in association with enhanced leg glucose uptake during postexercise recovery.

21 January 2018

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Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle.

21 January 2018

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Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging

21 January 2018

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Phosphatidic acid-mediated mitogenic activation of mTOR signaling

21 January 2018

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Plasma Amino Acid Levels and Insulin Secretion in Obesity

21 January 2018

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

21 January 2018

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Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160.

21 January 2018

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Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling

21 January 2018

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 January 2018

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Rapamycin's resurrection: a new way to target the cancer cell cycle

21 January 2018

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A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle.

21 January 2018

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The pharmacology of mTOR inhibition

21 January 2018

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Nutrient sensing in the mTOR/S6K1 signalling pathway.

21 January 2018

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Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

21 January 2018

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mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

21 January 2018

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

21 January 2018

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

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Exercise training-induced improvements in insulin action.

21 January 2018

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Upstream and downstream of mTOR

21 January 2018

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

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Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes.

21 January 2018

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Regulation of mTOR by mechanically induced signaling events in skeletal muscle.

21 January 2018

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The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle

21 January 2018

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mTOR is the rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr(389) in p70(S6k)

21 January 2018

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Effect of the volume and intensity of exercise training on insulin sensitivity

21 January 2018

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The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle.

21 January 2018

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

21 January 2018

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Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

21 January 2018

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Resistance training improves insulin sensitivity in NIDDM subjects without altering maximal oxygen uptake.

21 January 2018

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

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Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function.

21 January 2018

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Obesity and insulin resistance

21 January 2018

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Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

21 January 2018

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

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AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.

21 January 2018

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Nutrient-induced insulin resistance in human skeletal muscle

21 January 2018

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Mechanism of amino acid-induced skeletal muscle insulin resistance in humans

21 January 2018

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Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity

21 January 2018

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Elevated plasma free fatty acids decrease basal protein synthesis, but not the anabolic effect of leucine, in skeletal muscle

21 January 2018

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mVps34 is activated following high-resistance contractions

21 January 2018

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Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

21 January 2018

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Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle.

21 January 2018

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mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators

21 January 2018

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

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Bidirectional modulation of insulin action by amino acids

21 January 2018

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

21 January 2018

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Cell growth control: mTOR takes on fat.

21 January 2018

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Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels

21 January 2018

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Phosphorylation and activation of p70s6k by PDK1

21 January 2018

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Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside

21 January 2018

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Signaling mechanisms in skeletal muscle: acute responses and chronic adaptations to exercise

21 January 2018

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mTOR and cancer: insights into a complex relationship

21 January 2018

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

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The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation

21 January 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

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Growing roles for the mTOR pathway

21 January 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

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Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation

21 January 2018

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The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

21 January 2018

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Phospholipase D1 is an effector of Rheb in the mTOR pathway.

21 January 2018

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Critical nodes in signalling pathways: insights into insulin action

21 January 2018

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 January 2018

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Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin

21 January 2018

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Modulation of insulin action by dietary proteins and amino acids: role of the mammalian target of rapamycin nutrient sensing pathway

21 January 2018

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Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

21 January 2018

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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

21 January 2018

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

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Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

21 January 2018

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Amino acid availability regulates p70 S6 kinase and multiple translation factors

21 January 2018

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Effects of acute exercise and training on insulin action and sensitivity: focus on molecular mechanisms in muscle

21 January 2018

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21 January 2018

Expanding mTOR signaling

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Resistance training improves insulin signaling and action in skeletal muscle

21 January 2018

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Elevated glucose activates protein synthesis in cultured cardiac myocytes

21 January 2018

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Signal transduction: Linking nutrients to growth.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/H09-073

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21 August 2017

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PubMed ID

19935842