Role of the cAMP-binding protein Epac in cardiovascular physiology and pathophysiology (Q37621296)

21 August 2017

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title

Role of the cAMP-binding protein Epac in cardiovascular physiology and pathophysiology (English)

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21 August 2017

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6

Frank Lezoualc'h

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Mélanie Métrich

1

object named as

Mélanie Métrich

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Magali Berthouze

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object named as

Magali Berthouze

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Bertrand Crozatier

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object named as

Bertrand Crozatier

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author name string

Eric Morel

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PubMed ID

19855995

21 August 2017

Ana Maria Gomez

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21 August 2017

25 October 2009

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21 August 2017

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21 August 2017

459

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4

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21 August 2017

535-546

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https://scigraph.springernature.com/pub.10.1007/s00424-009-0747-y

21 August 2017

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cites work

Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels

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12 December 2020

Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy.

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12 December 2020

Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases.

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12 December 2020

Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.

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12 December 2020

The epidemiology of heart failure: the Framingham Study

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12 December 2020

cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells

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12 December 2020

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

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12 December 2020

RhoA GTPase and F-actin dynamically regulate the permeability of Cx43-made channels in rat cardiac myocytes

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12 December 2020

Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling

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12 December 2020

The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals

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12 December 2020

Excitation-transcription coupling in smooth muscle

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12 December 2020

Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis

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12 December 2020

Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells

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12 December 2020

A novel signaling pathway mediates the inhibition of CCL3/4 expression by prostaglandin E2.

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12 December 2020

Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery

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12 December 2020

Epac1 regulates integrity of endothelial cell junctions through VE-cadherin

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12 December 2020

The cAMP binding protein Epac regulates cardiac myofilament function

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12 December 2020

Rho GTPases in cell biology

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12 December 2020

cAMP-induced PKCzeta activation increases functional CXCR4 expression on human CD34+ hematopoietic progenitors

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12 December 2020

PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways

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12 December 2020

Epac increases melanoma cell migration by a heparan sulfate-related mechanism

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12 December 2020

A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.

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12 December 2020

8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.

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12 December 2020

Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons

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12 December 2020

cAMP signaling in leukocyte transendothelial migration

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12 December 2020

Cytokines in atherosclerosis: pathogenic and regulatory pathways

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12 December 2020

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

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12 December 2020

Cyclic AMP signaling as a mediator of vasculogenic mimicry in aggressive human melanoma cells in vitro

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12 December 2020

Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes

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12 December 2020

A-kinase anchoring proteins: from protein complexes to physiology and disease

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12 December 2020

Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms.

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12 December 2020

Activation of protein kinase Calpha by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein beta-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells.

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12 December 2020

Endothelial hyperpermeability in vascular leakage

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12 December 2020

Functional characterization of the cAMP-binding proteins Epac in cardiac myocytes

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12 December 2020

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.

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12 December 2020

Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study

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12 December 2020

Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting

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12 December 2020

Epac signaling pathway involves STEF, a guanine nucleotide exchange factor for Rac, to regulate APP processing

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12 December 2020

Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation

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12 December 2020

Cardiac excitation-contraction coupling

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12 December 2020

Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

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12 December 2020

Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation

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12 December 2020

Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes

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12 December 2020

Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes

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12 December 2020

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

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12 December 2020

The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes

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12 December 2020

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

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12 December 2020

Cytoskeletal regulation of pulmonary vascular permeability

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12 December 2020

Epac: effectors and biological functions

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12 December 2020

Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function

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12 December 2020

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

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12 December 2020

Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

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12 December 2020

Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

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12 December 2020

Inhibitory control of TGF-beta1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes.

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12 December 2020

The role of cytoskeleton in the regulation of vascular endothelial barrier function

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12 December 2020

Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy

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12 December 2020

Prostaglandin E2 suppresses lipopolysaccharide-stimulated IFN-beta production

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12 December 2020

cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling

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12 December 2020

EPAC proteins transduce diverse cellular actions of cAMP.

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12 December 2020

Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation

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12 December 2020

GEFs and GAPs: critical elements in the control of small G proteins

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12 December 2020

Cyclic nucleotide analogs as probes of signaling pathways.

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12 December 2020

Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function

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12 December 2020

Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A

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12 December 2020

Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration

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12 December 2020

Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval.

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12 December 2020

Inhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement

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12 December 2020

cGMP signaling through cAMP- and cGMP-dependent protein kinases.

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12 December 2020

A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

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12 December 2020

Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury.

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12 December 2020

A family of cAMP-binding proteins that directly activate Rap1

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12 December 2020

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

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12 December 2020

Angiogenesis in life, disease and medicine

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12 December 2020

Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis.

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12 December 2020

Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors

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12 December 2020

Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway

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12 December 2020

Calcium cycling and signaling in cardiac myocytes.

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12 December 2020

AKAP signaling complexes: getting to the heart of the matter

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12 December 2020

Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase

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12 December 2020

Direct spatial control of Epac1 by cyclic AMP.

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12 December 2020

Gap junction channel structure in the early 21st century: facts and fantasies

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12 December 2020

Epac proteins: multi-purpose cAMP targets

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12 December 2020

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

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12 December 2020

Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection

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12 December 2020

Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K.

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12 December 2020

Cyclic nucleotide research -- still expanding after half a century

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12 December 2020

Cyclic nucleotide-gated channels

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12 December 2020

Metabolites of an Epac-selective cAMP analog induce cortisol synthesis by adrenocortical cells through a cAMP-independent pathway

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12 December 2020

The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs

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12 December 2020

Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart

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12 December 2020

The role of TGF-beta signaling in myocardial infarction and cardiac remodeling

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12 December 2020

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

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12 December 2020

Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system

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12 December 2020

Alterations in cAMP-mediated signaling and their role in the pathophysiology of dilated cardiomyopathy

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12 December 2020

Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.

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12 December 2020

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

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12 December 2020

Epac in melanoma: a contributor to tumor cell physiology? Focus on "Epac increases melanoma cell migration by a heparin sulfate-related mechanism"

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12 December 2020

Cell physiology of cAMP sensor Epac

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12 December 2020

Small GTP-binding proteins and their regulators in cardiac hypertrophy

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12 December 2020

cAMP-binding protein Epac induces cardiomyocyte hypertrophy.

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12 December 2020

Identification of CCAAT/enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene.

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12 December 2020

cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics.

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12 December 2020

Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function

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12 December 2020

10.1007/S00424-009-0747-Y

Identifiers

DOI

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21 August 2017

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PubMed ID

19855995