Alterations in cAMP-mediated signaling and their role in the pathophysiology of dilated cardiomyopathy (Q36241719)

13 August 2017

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title

Alterations in cAMP-mediated signaling and their role in the pathophysiology of dilated cardiomyopathy (English)

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13 August 2017

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Matthew A Movsesian

1

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PubMed ID

16124995

13 August 2017

Michael R Bristow

series ordinal

2

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13 August 2017

1 January 2005

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Current Topics in Developmental Biology

13 August 2017

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13 August 2017

68

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13 August 2017

25-48

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Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a.

13 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Evaluation of a new bipyridine inotropic agent--milrinone--in patients with severe congestive heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Hemodynamic assessment of amrinone. A new inotropic agent

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Differences in beta-adrenergic neuroeffector mechanisms in ischemic versus idiopathic dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Effect of baseline or changes in adrenergic activity on clinical outcomes in the beta-blocker evaluation of survival trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Type 1 phosphatase, a negative regulator of cardiac function

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Targeting phospholamban by gene transfer in human heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Effects of Levosimendan, a cardiotonic agent targeted to troponin C, on cardiac function and on phosphorylation and Ca2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Effects of vesnarinone on morbidity and mortality in patients with heart failure. Vesnarinone Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Metoprolol controlled release/extended release in patients with severe heart failure: analysis of the experience in the MERIT-HF study

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Antiremodeling effects on the left ventricle during beta-blockade with metoprolol in the treatment of chronic heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Dual site phospholamban phosphorylation and its physiological relevance in the heart

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Novel use of a short-acting intravenous beta blocker in combination with inotropic therapy as a bridge to chronic oral beta blockade in patients with advanced heart failure.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Evidence for selective regulation of the phosphorylation of myocyte proteins by isoproterenol and prostaglandin E1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Increased beta-receptor density and improved hemodynamic response to catecholamine stimulation during long-term metoprolol therapy in heart failure from dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Positive inotropic and vasodilator actions of milrinone in patients with severe congestive heart failure. Dose-response relationships and comparison to nitroprusside

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Adverse consequences of high sympathetic nervous activity in the failing human heart

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Effects of β-Adrenergic Blocking Therapy on Left Ventricular Diastolic Relaxation Properties in Patients With Dilated Cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Carvedilol titration in patients with congestive heart failure receiving inotropic therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Effects of two Gbetagamma-binding proteins--N-terminally truncated phosducin and beta-adrenergic receptor kinase C terminus (betaARKct)--in heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Effects of carvedilol on left ventricular mass, chamber geometry, and mitral regurgitation in chronic heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Milrinone versus dobutamine in heart failure subjects treated chronically with carvedilol

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Increased activity of membrane-associated nucleoside diphosphate kinase and inhibition of cAMP synthesis in failing human myocardium

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Transcriptional regulation by the phosphorylation-dependent factor CREB

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-bi

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Beta-blocker therapy influences the hemodynamic response to inotropic agents in patients with heart failure: a randomized comparison of dobutamine and enoximone before and after chronic treatment with metoprolol or carvedilol

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Chronic beta 1-adrenoceptor antagonist treatment sensitizes beta 2-adrenoceptors, but desensitizes M2-muscarinic receptors in the human right atrium

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

PDE3 inhibition in dilated cardiomyopathy: reasons to reconsider

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Sarcoplasmic reticulum-associated cyclic adenosine 5'-monophosphate phosphodiesterase activity in normal and failing human hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Increased expression of cardiac phosphatases in patients with end-stage heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Increase in myocardial Gi-proteins in heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Evaluation of the effect of phosphodiesterase inhibitors on mortality in chronic heart failure patients. A meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: insights from the Flolan International Randomized Survival Trial (FIRST).

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Intermittent 6-month low-dose dobutamine infusion in severe heart failure: DICE multicenter trial

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Effect of carvedilol on survival in severe chronic heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Double-blind, placebo-controlled study of the effects of carvedilol in patients with moderate to severe heart failure. The PRECISE Trial. Prospective Randomized Evaluation of Carvedilol on Symptoms and Exercise.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Troponin I: inhibitor or facilitator

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Inotropic responses to isoproterenol and phosphodiesterase inhibitors in intact guinea pig hearts: comparison of cyclic AMP levels and phosphorylation of sarcoplasmic reticulum and myofibrillar proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Adenylyl cyclase increases survival in cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Increased cardiac adrenergic drive precedes generalized sympathetic activation in human heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Combined oral positive inotropic and beta-blocker therapy for treatment of refractory class IV heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Effects of metoprolol on myocardial beta-adrenoceptors and Gi alpha-proteins in patients with congestive heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Long-term therapy with a new cardiotonic agent, WIN 47203: drug-dependent improvement in cardiac performance and progression of the underlying disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

The acute hemodynamic effects of a new agent, MDL 17,043, in the treatment of congestive heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Multicenter trial of oral enoximone in patients with moderate to moderately severe congestive heart failure. Lack of benefit compared with placebo. Enoximone Multicenter Trial Group

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Isoforms of cyclic nucleotide phosphodiesterase PDE3A in cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Beta 1-adrenoceptor stimulation and beta 2-adrenoceptor stimulation differ in their effects on contraction, cytosolic Ca2+, and Ca2+ current in single rat ventricular cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Effect of milrinone on left ventricular relaxation and Ca(2+) uptake function of cardiac sarcoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Effectiveness of carvedilol alone versus carvedilol + pimobendan for severe congestive heart failure. For the Keio Interhospital Cardiology Study (KICS) Group

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2968002-7

7 January 2021

10.1016/S0070-2153(05)68002-7

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16124995