Cell physiology of cAMP sensor Epac (Q27863934)

4

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Mark Harbeck

3

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Guoxin Kang

2

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George G Holz

1

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language of work or name

English

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publication date

15 November 2006

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published in

Journal of Physiology

1 reference

cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells

volume

577

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page(s)

5-15

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issue

Pt 1

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cites work

1 reference

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cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells

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Evidence for the involvement of cAMP-GEF (Epac) pathway in amylase release from the rat parotid gland

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Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis

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Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I

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Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation

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Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells

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Differential modulation of Cav1.2 and Cav1.3-mediated glucose-stimulated insulin secretion by cAMP in INS-1 cells: distinct roles for exchange protein directly activated by cAMP 2 (Epac2) and protein kinase A.

29 September 2017

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Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

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Regulation of sodium-proton exchanger isoform 3 (NHE3) by PKA and exchange protein directly activated by cAMP (EPAC).

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Multiple cAMP-induced signaling cascades regulate prolactin expression in T cells

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Microtubule-associated proteins (MAPs) regulate cAMP signalling through exchange protein directly activated by cAMP (EPAC).

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PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis

29 September 2017

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Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line

29 September 2017

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Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.

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cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction.

29 September 2017

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Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway

29 September 2017

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Integration of ATP, cAMP, and Ca2+ signals in insulin granule exocytosis

29 September 2017

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Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

29 September 2017

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Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments

29 September 2017

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Novel single chain cAMP sensors for receptor-induced signal propagation.

29 September 2017

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Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

Amplification of exocytosis by Ca2+-induced Ca2+ release in INS-1 pancreatic beta cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

Preferential potentiation of fast-releasing synaptic vesicles by cAMP at the calyx of Held

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

Membrane phospholipid control of nucleotide sensitivity of KATP channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

Progesterone secretion by luteinizing human granulosa cells: a possible cAMP-dependent but PKA-independent mechanism involved in its regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

PIP2 and PIP as determinants for ATP inhibition of KATP channels

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000694

Epac: a new cAMP target and new avenues in cAMP research

2 June 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

Calcium-induced acrosomal exocytosis requires cAMP acting through a protein kinase A-independent, Epac-mediated pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

Presynaptic effectors contributing to cAMP-induced synaptic potentiation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

Cyclic AMP/cAMP-GEF pathway amplifies insulin exocytosis induced by Ca2+ and ATP in rat islet beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

Presynaptic mechanism underlying cAMP-dependent synaptic potentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

cAMP-binding protein Epac induces cardiomyocyte hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

Exposure to cAMP and beta-adrenergic stimulation recruits Ca(V)3 T-type channels in rat chromaffin cells through Epac cAMP-receptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

Direct modulation of synaptic vesicle priming by GABA(B) receptor activation at a glutamatergic synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

cAMP increases Ca2+-dependent exocytosis through both PKA and Epac2 in mouse melanotrophs from pituitary tissue slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.119644

Epac1 regulates integrity of endothelial cell junctions through VE-cadherin

21 January 2018

1 reference

12 December 2020

Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes

1 reference

12 December 2020

Epac-mediated Ca(2+) mobilization and exocytosis in inner medullary collecting duct

1 reference

12 December 2020

Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells

1 reference

12 December 2020

Glucagon activates Ca2+ and Cl- channels in rat hepatocytes

1 reference

12 December 2020

Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition

1 reference

12 December 2020

10.1113/JPHYSIOL.2006.119644

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1905158

1905158

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference

15 November 2016

1 reference