P2X7-mediated chemoprevention of epithelial cancers (Q37618815)

21 August 2017

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title

P2X7-mediated chemoprevention of epithelial cancers (English)

1 reference

21 August 2017

George I Gorodeski

1

1 reference

PubMed ID

19845494

21 August 2017

language of work or name

English

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publication date

1 November 2009

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Expert Opinion on Therapeutic Targets

21 August 2017

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21 August 2017

13

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21 August 2017

11

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21 August 2017

1313-1332

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Cancer stem cells: implications for the progression and treatment of metastatic disease.

21 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Cell death: the significance of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Mechanisms and Functions of Cell Death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

The DNA damage response, immunity and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Mitochondrial DNA mutations and apoptosis in mammalian aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Role of alterations in the apoptotic machinery in sensitivity of cancer cells to treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Senescence, apoptosis and therapy--cutting the lifelines of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Therapeutic targeting of apoptosis pathways in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Mechanisms of caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Killing time for cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Therapeutic potential of AIF-mediated caspase-independent programmed cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Bcl-G, a novel pro-apoptotic member of the Bcl-2 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

21 January 2018

The Bcl-2 protein family

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Apoptotic pathways: ten minutes to dead

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

The role of caspases in cell death and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Apoptosis in normal and cancer stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Targeting apoptosis as an approach for gastrointestinal cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

TRAIL receptor-targeted therapeutics: resistance mechanisms and strategies to avoid them.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Selective anticancer strategies via intervention of the death pathways relevant to cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

TRAIL and apoptosis induction by TNF-family death receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Apoptosis: identification of dying cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

P2X7 receptor-mediated apoptosis of human cervical epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Antiapoptotic effects of estrogen in normal and cancer human cervical epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Epidermal growth factor facilitates epinephrine inhibition of P2X7-receptor-mediated pore formation and apoptosis: a novel signaling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Regulation of P2X(7) gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Proteomic and functional evidence for a P2X7 receptor signalling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Molecular physiology of P2X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Signaling at purinergic P2X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Glu496Ala polymorphism of human P2X7 receptor does not affect its electrophysiological phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Identification and characterization of splice variants of the human P2X7 ATP channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

ATP released by LPS increases nitric oxide production in raw 264.7 macrophage cell line via P2Z/P2X7 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Pharmacological characterization of ATP- and LPS-induced IL-1beta release in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Effect of ATP on intracellular pH in pancreatic ducts involves P2X7 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

TNF-induced signaling in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

P2X7 purinoceptor expression in Xenopus oocytes is not sufficient to produce a pore-forming P2Z-like phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Characteristics of P2X7 receptors from human B lymphocytes expressed in Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

P2X7 receptor-Pannexin1 complex: pharmacology and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Evidence for functional P2X4/P2X7 heteromeric receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Analysis of assembly and trafficking of native P2X4 and P2X7 receptor complexes in rodent immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

P2X7 subunit-like immunoreactivity in the nucleus of visceral smooth muscle cells of the guinea pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Apically sorted P2X7 receptors mediate purinergic-induced pore formation preferentially in apical domains of the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

P2X(7) receptor expression is decreased in epithelial cancer cells of ectodermal, uro-genital sinus, and distal paramesonephric duct origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Acetylation of p53 inhibits its ubiquitination by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Specific in vitro initiation of transcription on the adenovirus type 2 early and late EII transcription units

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Transcriptional regulation by p53: one protein, many possibilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Increased expression of the pro-apoptotic ATP-sensitive P2X7 receptor in experimental and human glomerulonephritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

MicroRNAs miR-186 and miR-150 down-regulate expression of the pro-apoptotic purinergic P2X7 receptor by activation of instability sites at the 3'-untranslated region of the gene that decrease steady-state levels of the transcript

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

MicroRNA expression profiles classify human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Human epidermal and monocyte-derived langerhans cells express functional P2X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Regulation of immune response by P2X7 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Cell signaling via the P2X(7) nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

P2X7 receptors in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

P2X7 nucleotide receptor plays an important role in callus remodeling during fracture repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Purinergic P2X7 receptors mediate ATP-induced saliva secretion by the mouse submandibular gland.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Decreased expression of P2X7 in endometrial epithelial pre-cancerous and cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Increased P2X7 receptor expression and function in thyroid papillary cancer: a new potential marker of the disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

The epidermal growth factor receptor: from development to tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Risk factors for the progression or persistence of untreated mild dysplasia of the uterine cervix

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Randomized clinical trial of adenosine 5′-triphosphate on tumor growth and survival in advanced lung cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Beneficial effects of adenosine triphosphate on nutritional status in advanced lung cancer patients: a randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Adenosine triphosphate infusion increases liver energy status in advanced lung cancer patients: an in vivo 31P magnetic resonance spectroscopy study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

21 January 2018

P2 receptors and cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

P2X(7): a growth-promoting receptor-implications for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

ATP- and adenosine-mediated signaling in the central nervous system: adenosine receptor activation by ATP through rapid and localized generation of adenosine by ecto-nucleotidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Purinergic receptor-mediated effects of adenosine 5'-triphosphate in urological malignant diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Effect of extracellular ATP on the growth of hormone-refractory prostate cancer in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Characterization of calcium-independent purinergic receptor-mediated apoptosis in hormone-refractory prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Serum constituents can affect 2'-& 3'-O-(4-benzoylbenzoyl)-ATP potency at P2X(7) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Benzoyl ATP is an antagonist of rat and human P2Y1 receptors and of platelet aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Pharmacological characterization of recombinant human and rat P2X receptor subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Ecto-nucleotidases and nucleoside transporters mediate activation of adenosine receptors on hippocampal mossy fibers by P2X7 receptor agonist 2'-3'-O-(4-benzoylbenzoyl)-ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Agonists and antagonists acting at P2X7 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

The high-risk benign tumor: evidence from the two-stage skin cancer model and relevance for human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Prognosis of oral pre-malignant lesions: significance of clinical, histopathological, and molecular biological characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

Management of cervical premalignant lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

The P2X7receptor as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903277249

10.1517/14728220903277249

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19845494