An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms (Q37506106)

20 August 2017

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title

An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms (English)

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20 August 2017

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2

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20 August 2017

Alice I Bartlett

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20 August 2017

1 June 2009

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Nature Structural & Molecular Biology

20 August 2017

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20 August 2017

16

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20 August 2017

6

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20 August 2017

582-588

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https://scigraph.springernature.com/pub.10.1038/nsmb.1592

20 August 2017

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cites work

From the first protein structures to our current knowledge of protein folding: delights and scepticisms

1 reference

The protein folding 'speed limit'.

31 March 2020

1 reference

The Levinthal paradox: yesterday and today

31 March 2020

1 reference

Intermediates: ubiquitous species on folding energy landscapes?

31 March 2020

1 reference

Funnels, pathways, and the energy landscape of protein folding: a synthesis

31 March 2020

1 reference

Theory of protein folding

31 March 2020

1 reference

Localizing frustration in native proteins and protein assemblies

31 March 2020

1 reference

Probe-dependent and nonexponential relaxation kinetics: unreliable signatures of downhill protein folding

31 March 2020

1 reference

Comment on Probe-dependent and nonexponential relaxation kinetics: unreliable signatures of downhill protein folding

31 March 2020

1 reference

Criteria for downhill protein folding: calorimetry, chevron plot, kinetic relaxation, and single-molecule radius of gyration in chain models with subdued degrees of cooperativity.

31 March 2020

1 reference

Structural biology: analysis of 'downhill' protein folding.

31 March 2020

1 reference

Analysis of protein-folding cooperativity

31 March 2020

1 reference

Kinetics are probe-dependent during downhill folding of an engineered lambda6-85 protein

31 March 2020

1 reference

Atom-by-atom analysis of global downhill protein folding

31 March 2020

1 reference

Expanding the realm of ultrafast protein folding: gpW, a midsize natural single-domain with alpha+beta topology that folds downhill.

31 March 2020

1 reference

Distinguishing between cooperative and unimodal downhill protein folding

31 March 2020

1 reference

Protein folding studied by single-molecule FRET.

31 March 2020

1 reference

Ultrafast and downhill protein folding

31 March 2020

1 reference

Solution structure of a protein denatured state and folding intermediate.

31 March 2020

1 reference

Determination of an ensemble of structures representing the intermediate state of the bacterial immunity protein Im7.

31 March 2020

1 reference

The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints

31 March 2020

1 reference

Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values

31 March 2020

1 reference

Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins

31 March 2020

1 reference

Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.

31 March 2020

1 reference

Phi-value analysis of a three-state protein folding pathway by NMR relaxation dispersion spectroscopy

31 March 2020

1 reference

Early events in protein folding explored by rapid mixing methods

31 March 2020

1 reference

The protein folding problem

31 March 2020

1 reference

Probing invisible, low-populated States of protein molecules by relaxation dispersion NMR spectroscopy: an application to protein folding

31 March 2020

1 reference

Unfolded Protein and Peptide Dynamics Investigated with Single-Molecule FRET and Correlation Spectroscopy from Picoseconds to Seconds†

31 March 2020

1 reference

Mapping protein collapse with single-molecule fluorescence and kinetic synchrotron radiation circular dichroism spectroscopy

31 March 2020

1 reference

Determination of the transition state ensemble for the folding of ubiquitin from a combination of Phi and Psi analyses.

31 March 2020

1 reference

Molecular simulation as an aid to experimentalists.

31 March 2020

1 reference

Atomically detailed description of the unfolding of alpha-lactalbumin by the combined use of experiments and simulations

31 March 2020

1 reference

Improved structural characterizations of the drkN SH3 domain unfolded state suggest a compact ensemble with native-like and non-native structure

31 March 2020

1 reference

Backbone dynamics of the monomeric lambda repressor denatured state ensemble under nondenaturing conditions

31 March 2020

1 reference

Characterisation of the conformational properties of urea-unfolded Im7: implications for the early stages of protein folding.

31 March 2020

1 reference

Formation of native and non-native interactions in ensembles of denatured ACBP molecules from paramagnetic relaxation enhancement studies

31 March 2020

1 reference

Random-coil behavior and the dimensions of chemically unfolded proteins

31 March 2020

1 reference

Loop formation in unfolded polypeptide chains on the picoseconds to microseconds time scale

31 March 2020

1 reference

The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding

31 March 2020

1 reference

The analysis of protein folding kinetic data produced in protein engineering experiments

31 March 2020

1 reference

Origin of unusual phi-values in protein folding: evidence against specific nucleation sites

31 March 2020

1 reference

Phi-value analysis and the nature of protein-folding transition states

31 March 2020

1 reference

Denatured State Effects and the Origin of Nonclassical φ Values in Protein Folding

31 March 2020

1 reference

Protein folding and misfolding

31 March 2020

1 reference

Detection of a hidden folding intermediate in the focal adhesion target domain: Implications for its function and folding

31 March 2020

1 reference

Two-state folding observed in individual protein molecules

31 March 2020

1 reference

Single-molecule Forster resonance energy transfer study of protein dynamics under denaturing conditions

31 March 2020

1 reference

Direct observation of the three-state folding of a single protein molecule

31 March 2020

1 reference

Revealing the bifurcation in the unfolding pathways of GFP by using single-molecule experiments and simulations

31 March 2020

1 reference

The family feud: do proteins with similar structures fold via the same pathway?

31 March 2020

1 reference

Destabilization of the Escherichia coli RNase H kinetic intermediate: switching between a two-state and three-state folding mechanism.

31 March 2020

1 reference

Contact order, transition state placement and the refolding rates of single domain proteins.

31 March 2020

1 reference

Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition

31 March 2020

1 reference

The folding of hen lysozyme involves partially structured intermediates and multiple pathways

31 March 2020

1 reference

Parallel protein-unfolding pathways revealed and mapped

31 March 2020

1 reference

Prolyl isomerization as a molecular timer in phage infection

31 March 2020

1 reference

Population of on-pathway intermediates in the folding of ubiquitin.

31 March 2020

1 reference

A kinetic explanation for the rearrangement pathway of BPTI folding

31 March 2020

1 reference

Malleability of protein folding pathways: a simple reason for complex behaviour

31 March 2020

1 reference

Identification of the minimal protein-folding nucleus through loop-entropy perturbations

31 March 2020

1 reference

Changes of protein folding pathways by circular permutation. Overlapping nuclei promote global cooperativity

31 March 2020

1 reference

The energy landscapes of repeat-containing proteins: topology, cooperativity, and the folding funnels of one-dimensional architectures

31 March 2020

1 reference

Rational redesign of the folding pathway of a modular protein

31 March 2020

1 reference

Rerouting the folding pathway of the Notch ankyrin domain by reshaping the energy landscape

31 March 2020

1 reference

The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection

31 March 2020

1 reference

Life on the edge: a link between gene expression levels and aggregation rates of human proteins

31 March 2020

1 reference

Structure-function-folding relationship in a WW domain

31 March 2020

1 reference

Extracting function from a beta-trefoil folding motif

31 March 2020

1 reference

Backtracking on the folding landscape of the beta-trefoil protein interleukin-1beta?

31 March 2020

1 reference

Adapting proteostasis for disease intervention

31 March 2020

1 reference

Macromolecular crowding: obvious but underappreciated

31 March 2020

1 reference

Chaperone machines in action

31 March 2020

1 reference

Residue-level interrogation of macromolecular crowding effects on protein stability.

31 March 2020

1 reference

Macromolecular crowding compacts unfolded apoflavodoxin and causes severe aggregation of the off-pathway intermediate during apoflavodoxin folding.

31 March 2020

1 reference

Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences

31 March 2020

1 reference

Thermodynamics and kinetics of protein folding under confinement

31 March 2020

1 reference

Effects of crowding and confinement on the structures of the transition state ensemble in proteins.

31 March 2020

1 reference

Crowded, cell-like environment induces shape changes in aspherical protein

31 March 2020

1 reference

Converging concepts of protein folding in vitro and in vivo

31 March 2020

1 reference

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins

31 March 2020

1 reference

Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy

31 March 2020

1 reference

Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells

31 March 2020

1 reference

Probing transcription factor dynamics at the single-molecule level in a living cell

31 March 2020

1 reference

Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins.

31 March 2020

1 reference

Probing Protein-Chaperone Interactions with Single-Molecule Fluorescence Spectroscopy

31 March 2020

1 reference

Monitoring Protein Conformation along the Pathway of Chaperonin-Assisted Folding

31 March 2020

1 reference

Macromolecular crowding in the Escherichia coli periplasm maintains alpha-synuclein disorder.

31 March 2020

1 reference

Quantitative NMR analysis of the protein G B1 domain in Xenopus laevis egg extracts and intact oocytes

31 March 2020

1 reference

Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling

31 March 2020

1 reference

Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant

31 March 2020

1 reference

Folding trajectories of human dihydrofolate reductase inside the GroEL GroES chaperonin cavity and free in solution

31 March 2020

1 reference

Probing protein folding and conformational transitions with fluorescence.

31 March 2020

1 reference

How to study proteins by circular dichroism

31 March 2020

1 reference

Protein dynamics from time resolved UV Raman spectroscopy

31 March 2020

1 reference

Methods to study protein folding by stopped-flow FT-IR.

31 March 2020

1 reference

Fluorescence correlation spectroscopy: novel variations of an established technique

31 March 2020

1 reference

Small-angle X-ray scattering from RNA, proteins, and protein complexes

31 March 2020

1 reference

Elucidation of the protein folding landscape by NMR.

31 March 2020

1 reference

Hydrogen exchange methods to study protein folding

31 March 2020

1 reference

Protein conformations, interactions, and H/D exchange

31 March 2020

1 reference

Protein structure determination in living cells by in-cell NMR spectroscopy

31 March 2020

1 reference

High-resolution multi-dimensional NMR spectroscopy of proteins in human cells.

31 March 2020

1 reference

Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19491935

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A structural comparison of the colicin immunity proteins Im7 and Im9 gives new insights into the molecular determinants of immunity-protein specificity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19491935

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Crystal structure of the ribosomal protein S6 from Thermus thermophilus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19491935

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1592

1 reference

20 August 2017

1 reference

PubMed ID

19491935