Targeting the CNS to treat type 2 diabetes (Q37464738)

20 August 2017

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title

Targeting the CNS to treat type 2 diabetes (English)

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20 August 2017

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Darleen A Sandoval

1

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20 August 2017

Silvana Obici

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2

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20 August 2017

Randy J Seeley

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3

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20 August 2017

language of work or name

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1 May 2009

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Nature Reviews Drug Discovery

20 August 2017

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20 August 2017

8

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20 August 2017

5

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20 August 2017

386-398

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https://scigraph.springernature.com/pub.10.1038/nrd2874

20 August 2017

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Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors

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The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans

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Regulation of lipid metabolism by the AMP-activated protein kinase

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The milieu interieur and the islets of Langerhans

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31 March 2020

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Metabolic consequences of exercise-associated autonomic failure

31 March 2020

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Role of brain in counterregulation of insulin-induced hypoglycemia in dogs

31 March 2020

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Regulation of blood glucose by hypothalamic pyruvate metabolism

31 March 2020

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Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

31 March 2020

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Hypothalamic sensing of fatty acids

31 March 2020

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Hypothalamic K(ATP) channels control hepatic glucose production

31 March 2020

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Central leptin acutely reverses diet-induced hepatic insulin resistance

31 March 2020

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Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

31 March 2020

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Hypothalamic insulin signaling is required for inhibition of glucose production

31 March 2020

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Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

31 March 2020

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Central administration of oleic acid inhibits glucose production and food intake

31 March 2020

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Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake

31 March 2020

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Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats

31 March 2020

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Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling.

31 March 2020

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The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity

31 March 2020

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Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo

31 March 2020

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31 March 2020

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31 March 2020

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Efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes: a 54-week study

31 March 2020

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Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans

31 March 2020

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Diabetes mellitus nach Pankreasexstirpation

31 March 2020

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Acute Hyperinsulinemia and Its Reversal by Vagotomy after Lesions of the Ventromedial Hypothalamus in Anesthetized Rats*

31 March 2020

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Reduced glycogen phosphorylase activity in denervated hindlimb muscles of rat is related to muscle atrophy and fibre type.

31 March 2020

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Monitoring of stored and available fuel by the CNS: implications for obesity

31 March 2020

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Central nervous system control of food intake

31 March 2020

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Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats.

31 March 2020

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Regulatory mechanism of the ventromedial hypothalamus in enhancing glucose uptake in skeletal muscles.

31 March 2020

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Insulin's direct effects on the liver dominate the control of hepatic glucose production

31 March 2020

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Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

31 March 2020

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The catabolic action of insulin in the brain is mediated by melanocortins.

31 March 2020

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Drug discovery approaches targeting the PI3K/Akt pathway in cancer

31 March 2020

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The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance

31 March 2020

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Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia

31 March 2020

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AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

31 March 2020

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Leptin enters the brain by a saturable system independent of insulin

31 March 2020

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Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes.

31 March 2020

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Melanocortin-independent effects of leptin on hepatic glucose fluxes

31 March 2020

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Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.

31 March 2020

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Critical role of STAT3 in leptin's metabolic actions

31 March 2020

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STAT3 signalling is required for leptin regulation of energy balance but not reproduction

31 March 2020

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Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

31 March 2020

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Hypothalamic mTOR signaling regulates food intake

31 March 2020

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Mammalian TOR: a homeostatic ATP sensor

31 March 2020

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AMP-activated protein kinase plays a role in the control of food intake

31 March 2020

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Serum immunoreactive-leptin concentrations in normal-weight and obese humans

31 March 2020

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Characterization of the resistance to the anorectic and endocrine effects of leptin in obesity-prone and obesity-resistant rats fed a high-fat diet.

31 March 2020

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Endoplasmic reticulum stress plays a central role in development of leptin resistance

31 March 2020

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Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

31 March 2020

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Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system.

31 March 2020

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Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis

31 March 2020

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Glucagon-like peptide-1 binding to rat hepatic membranes

31 March 2020

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Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor.

31 March 2020

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Tissue distribution of rat glucagon receptor and GLP-1 receptor gene expression1This work was supported by a grant from the Crohn's and Colitis Foundation of America.1

31 March 2020

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Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones.

31 March 2020

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Insulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors.

31 March 2020

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Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats

31 March 2020

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Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells

31 March 2020

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Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage

31 March 2020

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Gastric relaxation induced by hyperglycemia is mediated by vagal afferent pathways in the rat.

31 March 2020

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Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing

31 March 2020

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Brain glucosensing and the K(ATP) channel

31 March 2020

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Neuronal glucose sensing: still a physiological orphan?

31 March 2020

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The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.

31 March 2020

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Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion.

31 March 2020

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C75 inhibits food intake by increasing CNS glucose metabolism

31 March 2020

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Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects

31 March 2020

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Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system

31 March 2020

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Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

31 March 2020

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Molecular disruption of hypothalamic nutrient sensing induces obesity

31 March 2020

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The role of hypothalamic malonyl-CoA in energy homeostasis.

31 March 2020

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Fatty acid metabolism as a target for obesity treatment

31 March 2020

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Beta oxidation in the brain is required for the effects of non-esterified fatty acids on glucose-induced insulin secretion in rats.

31 March 2020

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Role for mitochondrial reactive oxygen species in brain lipid sensing: redox regulation of food intake.

31 March 2020

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Regulation of intracellular pH by cultured opossum kidney cells

31 March 2020

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Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production

31 March 2020

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The S6 kinase signaling pathway in the control of development and growth.

31 March 2020

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Role of neuronal energy status in the regulation of adenosine 5'-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior

31 March 2020

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Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation

31 March 2020

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Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypoglycaemia in rats

31 March 2020

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Counterregulatory adaptation to recurrent hypoglycemia in normal humans

31 March 2020

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Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans

31 March 2020

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Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia

31 March 2020

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Nutrient sensing and metabolic decisions

31 March 2020

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

31 March 2020

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TOR signaling in growth and metabolism

31 March 2020

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The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity.

31 March 2020

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AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

31 March 2020

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Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain.

31 March 2020

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The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides

31 March 2020

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Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation

31 March 2020

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Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

31 March 2020

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Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats

31 March 2020

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Dopamine and serotonin VMN release is related to feeding status in obese and lean Zucker rats.

31 March 2020

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Effectiveness of antipsychotic drugs in patients with chronic schizophrenia

31 March 2020

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Metabolic dysregulation with atypical antipsychotics occurs in the absence of underlying disease: a placebo-controlled study of olanzapine and risperidone in dogs

31 March 2020

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Acute effects of atypical antipsychotics on whole-body insulin resistance in rats: implications for adverse metabolic effects

31 March 2020

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Insulin resistance and decreased glucose-stimulated insulin secretion after acute olanzapine administration

31 March 2020

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Bromocriptine/SKF38393 treatment ameliorates obesity and associated metabolic dysfunctions in obese (ob/ob) mice

31 March 2020

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Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene

31 March 2020

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Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus

31 March 2020

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Beta-endorphin innervation of dopamine neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study

31 March 2020

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Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways

31 March 2020

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5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis

31 March 2020

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Pharmacological targeting of the serotonergic system for the treatment of obesity

31 March 2020

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Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

31 March 2020

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Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity

31 March 2020

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Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

31 March 2020

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Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR treatment

31 March 2020

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

31 March 2020

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Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

31 March 2020

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AMPK and PPARdelta agonists are exercise mimetics

31 March 2020

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Hypothalamic CaMKK2 contributes to the regulation of energy balance

31 March 2020

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The blood-brain barrier as a cause of obesity

31 March 2020

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Impaired transport of leptin across the blood-brain barrier in obesity

31 March 2020

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Effect of diet-induced obesity and experimental hyperinsulinemia on insulin uptake into CSF of the rat.

31 March 2020

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Reduced effect of experimental peripheral hyperinsulinemia to elevate cerebrospinal fluid insulin concentrations of obese Zucker rats

31 March 2020

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Getting into the brain: approaches to enhance brain drug delivery

31 March 2020

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Redox drug delivery systems for targeting drugs to the brain

31 March 2020

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Effect of molecular manipulation on the estrogenic activity of a brain-targeting estradiol chemical delivery system

31 March 2020

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Nanoparticulate systems for brain delivery of drugs

31 March 2020

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Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

31 March 2020

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Two-year pulmonary safety and efficacy of inhaled human insulin (Exubera) in adult patients with type 2 diabetes

31 March 2020

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Functional neuroimaging: a new generation of human brain studies in obesity research

31 March 2020

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Food intake and the regulation of body weight.

31 March 2020

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Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine

31 March 2020

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Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice

31 March 2020

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Effects of glycemic control on target organ responses to epinephrine in type 1 diabetes

31 March 2020

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Intracellular signalling. Key enzyme in leptin-induced anorexia

31 March 2020

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Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

31 March 2020

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Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats.

31 March 2020

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The role of CNS fuel sensing in energy and glucose regulation.

31 March 2020

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Pancreatic extracts. 1922.

31 March 2020

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12 December 2020

Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C.

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12 December 2020

Glucagon and the glucagon-like peptides

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12 December 2020

Regulation of glycogen metabolism in liver by the autonomic nervous system. II. Neural control of glycogenolytic enzymes

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12 December 2020

The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action

1 reference

12 December 2020

Dynamic and static phases of obesity following lesions in PVN and VMH.

1 reference

12 December 2020

Effects of duodenal and distal ileal infusions of glucose and oleic acid on meal patterns in rats

1 reference

12 December 2020

Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients.

1 reference

12 December 2020

Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats

1 reference

12 December 2020

Local intracerebral delivery of endogenous inhibitors by osmotic minipumps effectively suppresses glioma growth in vivo

1 reference

12 December 2020

Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid

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12 December 2020

Intraduodenal infusions of fats elicit satiety in sham-feeding rats

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12 December 2020

Transplantation of pancreatic beta-cells prevents development of hypothalamic obesity in rats

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12 December 2020

Identifiers

DOI

10.1038/NRD2874

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Dimensions Publication ID

20 August 2017

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