Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein (Q37464182)

20 August 2017

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title

Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein (English)

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20 August 2017

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Masahiro Kawahara

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20 August 2017

Midori Negishi-Kato

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2

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20 August 2017

Yutaka Sadakane

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3

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20 August 2017

1 May 2009

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Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

20 August 2017

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20 August 2017

9

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20 August 2017

5

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20 August 2017

681-693

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The molecular pathology of Alzheimer's disease

20 August 2017

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade

21 January 2018

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Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

21 January 2018

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Linking calcium to Abeta and Alzheimer's disease

21 January 2018

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Neuronal and glial calcium signaling in Alzheimer's disease

21 January 2018

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Abeta ion channels. Prospects for treating Alzheimer's disease with Abeta channel blockers

21 January 2018

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Disruption of calcium homeostasis in the pathogenesis of Alzheimer's disease and other conformational diseases

21 January 2018

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Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm

21 January 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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Presenilin: running with scissors in the membrane

21 January 2018

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In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

21 January 2018

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Correlations of synaptic and pathological markers with cognition of the elderly

21 January 2018

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

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Age-dependent change in the levels of Abeta40 and Abeta42 in cerebrospinal fluid from control subjects, and a decrease in the ratio of Abeta42 to Abeta40 level in cerebrospinal fluid from Alzheimer's disease patients.

21 January 2018

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Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

21 January 2018

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

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Abeta-globulomers are formed independently of the fibril pathway

21 January 2018

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Amyloid beta-protein assembly and Alzheimer disease

21 January 2018

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Self-assembly of Abeta(1-42) into globular neurotoxins.

21 January 2018

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Synaptic pathology of Alzheimer's disease

21 January 2018

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

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A beta oligomers - a decade of discovery

21 January 2018

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Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

21 January 2018

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

21 January 2018

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Absence of synaptophysin near cortical neurons containing oligomer Abeta in Alzheimer's disease brain.

21 January 2018

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A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

21 January 2018

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Alzheimer's disease and Abeta toxicity: from top to bottom

21 January 2018

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Neuronal apoptosis after CNS injury: the roles of glutamate and calcium.

21 January 2018

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Implication of calpain in neuronal apoptosis. A possible regulation of Alzheimer's disease

21 January 2018

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Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein

21 January 2018

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SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production

21 January 2018

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beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

21 January 2018

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Disturbances of the neuronal calcium homeostasis in the aging nervous system

21 January 2018

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Bicuculline induces synapse formation on primary cultured accessory olfactory bulb neurons

21 January 2018

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Beta-amyloid enhances intracellular calcium rises mediated by repeated activation of intracellular calcium stores and nicotinic receptors in acutely dissociated rat basal forebrain neurons

21 January 2018

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Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum

21 January 2018

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Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes

21 January 2018

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Zn2+ interaction with Alzheimer amyloid beta protein calcium channels

21 January 2018

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Efficiency of histidine-associating compounds for blocking the alzheimer's Abeta channel activity and cytotoxicity

21 January 2018

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Abeta25-35 induces rapid lysis of red blood cells: contrast with Abeta1-42 and examination of underlying mechanisms

21 January 2018

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Membrane disruption by Alzheimer beta-amyloid peptides mediated through specific binding to either phospholipids or gangliosides. Implications for neurotoxicity.

21 January 2018

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Effects of beta-amyloid peptides on the fluidity of membranes from frontal and parietal lobes of human brain. High potencies of A beta 1-42 and A beta 1-43.

21 January 2018

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Soluble amyloid beta-oligomers affect dielectric membrane properties by bilayer insertion and domain formation: implications for cell toxicity

21 January 2018

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Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

21 January 2018

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Amyloid beta protein-(1-42) forms calcium-permeable, Zn2+-sensitive channel

21 January 2018

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Theoretical models of the ion channel structure of amyloid beta-protein

21 January 2018

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Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis

21 January 2018

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Alzheimer's disease amyloid beta-protein forms Zn(2+)-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons

21 January 2018

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Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line

21 January 2018

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Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis

21 January 2018

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Intracellular calcium changes in neuronal cells induced by Alzheimer's beta-amyloid protein are blocked by estradiol and cholesterol

21 January 2018

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Structure and functions of channel-forming peptides: magainins, cecropins, melittin and alamethicin

21 January 2018

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Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease.

21 January 2018

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Magainin 2 in action: distinct modes of membrane permeabilization in living bacterial and mammalian cells

21 January 2018

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21 January 2018

Conformational disease

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21 January 2018

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Neurotoxicity of a prion protein fragment.

21 January 2018

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Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

21 January 2018

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Alpha-synuclein: its biological function and role in neurodegenerative diseases

21 January 2018

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Aggregation and neurotoxicity of alpha-synuclein and related peptides

21 January 2018

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ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures

21 January 2018

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Channel formation by a neurotoxic prion protein fragment

21 January 2018

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Prion peptide fragment PrP[106-126] forms distinct cation channel types.

21 January 2018

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Polyglutamine-induced ion channels: a possible mechanism for the neurotoxicity of Huntington and other CAG repeat diseases

21 January 2018

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Neurodegenerative disease: amyloid pores from pathogenic mutations.

21 January 2018

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Amyloid ion channels: a common structural link for protein-misfolding disease

21 January 2018

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Different species of alpha-synuclein oligomers induce calcium influx and seeding.

21 January 2018

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Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro.

21 January 2018

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Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro

21 January 2018

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Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation

21 January 2018

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Copper, Zinc, and the Metallobiology of Alzheimer Disease

21 January 2018

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Mutual stimulation of beta-amyloid fibrillogenesis by clioquinol and divalent metals

21 January 2018

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Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels

21 January 2018

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Amyloid-beta immunisation for Alzheimer's disease

21 January 2018

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Inhibition of the electrostatic interaction between beta-amyloid peptide and membranes prevents beta-amyloid-induced toxicity

21 January 2018

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Domain formation induced by lipid-ion and lipid-peptide interactions.

21 January 2018

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Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity

21 January 2018

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

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Effect of 17 beta-estradiol on chondrocyte membrane fluidity and phospholipid metabolism is membrane-specific, sex-specific, and cell maturation-dependent.

21 January 2018

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Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AbetaP (1-40) and (1-42) peptides.

21 January 2018

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Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function

21 January 2018

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Novel brain function: biosynthesis and actions of neurosteroids in neurons

21 January 2018

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Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging

21 January 2018

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DHEA-S plasma levels and incidence of Alzheimer's disease.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERN.09.28

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release_jp2sm5gsczfvfdoiezh3gyqcdm

20 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/jp2sm5gsczfvfdoiezh3gyqcdm

mapped directly with Wikidata item

24 November 2022

based on heuristic

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