Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation (Q37403103)

20 August 2017

Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation (English)

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20 August 2017

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6

Bradley T Hyman

1 reference

20 August 2017

Li Chen

1

1 reference

20 August 2017

Magali Periquet

2

1 reference

20 August 2017

Xu Wang

3

1 reference

20 August 2017

Alessandro Negro

4

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20 August 2017

Pamela J McLean

5

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20 August 2017

Mel B Feany

7

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20 August 2017

language of work or name

English

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publication date

12 October 2009

1 reference

Journal of Clinical Investigation

20 August 2017

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20 August 2017

119

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20 August 2017

11

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20 August 2017

3257-3265

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describes a project that uses

20 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2769182/fullTextXML

inferred from PubMed Central ID database lookup

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Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

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6 September 2017

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Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

6 September 2017

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Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

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Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation

6 September 2017

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6 September 2017

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alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases

6 September 2017

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Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

6 September 2017

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Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death

6 September 2017

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14 September 2017

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Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

28 September 2017

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

26 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769182

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

26 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769182

Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson

2 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769182

Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease

2 September 2018

1 reference

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Pathological biochemistry of alpha-synucleinopathy

2 September 2018

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Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.

2 September 2018

1 reference

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Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769182

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

2 September 2018

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Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

2 September 2018

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Identification of rotenone-induced modifications in alpha-synuclein using affinity pull-down and tandem mass spectrometry.

2 September 2018

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Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

2 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769182

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769182

A century of cognitive decline.

2 September 2018

1 reference

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Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19855133

12 December 2020

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/19855133

12 December 2020

inferred from PubMed ID database lookup

Prevalence of movement disorders in elderly community residents

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19855133

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1172/JCI39088

1 reference

20 August 2017

1 reference

20 August 2017

1 reference