Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death (Q39971267)

16 September 2017

Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death (English)

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16 September 2017

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Naoto Sugeno

1

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16 September 2017

Atsushi Takeda

2

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16 September 2017

Takafumi Hasegawa

3

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16 September 2017

Michiko Kobayashi

4

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16 September 2017

Akio Kikuchi

5

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16 September 2017

Fumiaki Mori

6

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16 September 2017

Koichi Wakabayashi

7

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16 September 2017

Yasuto Itoyama

8

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16 September 2017

language of work or name

English

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publication date

18 June 2008

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Journal of Biological Chemistry

16 September 2017

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16 September 2017

283

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16 September 2017

34

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16 September 2017

23179-23188

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Molecular Pathways of Neurodegeneration in Parkinson's Disease

16 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M802223200

Lewy-body formation is an aggresome-related process: a hypothesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M802223200

21 January 2018

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Caught in the act: alpha-synuclein is the culprit in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M802223200

Alpha-synuclein and neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M802223200

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

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alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M802223200

Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes

21 January 2018

1 reference

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Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila

21 January 2018

1 reference

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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

1 reference

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Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Etiology and pathogenesis of Parkinson's disease

21 January 2018

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

21 January 2018

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

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Histochemical features of stress-induced aggregates in alpha-synuclein overexpressing cells.

21 January 2018

1 reference

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Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

21 January 2018

1 reference

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Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.

21 January 2018

1 reference

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A century-old debate on protein aggregation and neurodegeneration enters the clinic

21 January 2018

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

1 reference

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Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

The mammalian unfolded protein response

21 January 2018

1 reference

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

β-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the golgi complex, shows homology to β-adaptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Chronic reduction in complex I function alters calcium signaling in SH-SY5Y neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Lewy Bodies of Parkinson's Disease Contain Neurofilament Antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Synucleins are a novel class of substrates for G protein-coupled receptor kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

1 reference

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JNK signalling: a possible target to prevent neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Activation of the unfolded protein response in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism

21 January 2018

1 reference

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Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

21 January 2018

1 reference

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Protein folding and misfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Beta-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function

21 January 2018

1 reference

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802223200

Oxidative stress-triggered unfolded protein response is upstream of intrinsic cell death evoked by parkinsonian mimetics.

21 January 2018

1 reference

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Proteasomal function is impaired in substantia nigra in Parkinson's disease

21 January 2018

1 reference

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Brain proteasomal function in sporadic Parkinson's disease and related disorders

21 January 2018

1 reference

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Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the α-synuclein gene in early onset patients

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M802223200

1 reference

16 September 2017

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