Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy (Q24683089)

1

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Susmita Kaushik

3

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Antonia Follenzi

Antonia Follenzi

10

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William T Dauer

William Dauer

11

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Dave Soldier

15

David Sulzer

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Serge Przedborski

12

Serge Przedborski

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author name string

Zsolt Talloczy

2

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Ashish C Massey

4

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Joseph Mazzulli

5

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Eugene V Mosharov

6

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Roberto Hodara

7

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Ross Fredenburg

8

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Du-Chu Wu

9

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Harry Ischiropoulos

13

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Peter T Lansbury

Journal of Clinical Investigation

14

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language of work or name

English

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publication date

February 2008

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published in

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volume

118

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page(s)

777-88

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issue

2

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cites work

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

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Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery

28 September 2017

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Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.

28 September 2017

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Effects of small molecules on chaperone-mediated autophagy

28 September 2017

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Consequences of the selective blockage of chaperone-mediated autophagy

28 September 2017

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Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

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Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

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Autophagy: in sickness and in health

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Intracellular patch electrochemistry: regulation of cytosolic catecholamines in chromaffin cells.

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

28 September 2017

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Induction of alpha-synuclein aggregation by intracellular nitrative insult.

28 September 2017

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28 September 2017

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Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.

28 September 2017

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Import of a cytosolic protein into lysosomes by chaperone-mediated autophagy depends on its folding state

28 September 2017

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28 September 2017

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Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture

28 September 2017

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Polypeptide import and degradation by isolated lysosomes

30 May 2018

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30 May 2018

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Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

30 May 2018

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Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.

28 November 2018

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Nitration and increased alpha-synuclein expression associated with dopaminergic neurodegeneration in equine pituitary pars intermedia dysfunction.

28 November 2018

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Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157565

Structural determinants of PLD2 inhibition by alpha-synuclein

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157565

3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157565

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157565

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157565

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157565

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157565

Synaptic vesicle transporter expression regulates vesicle phenotype and quantal size.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157565

Genetics of Parkinson's disease

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18172548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18172548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Alpha-synuclein overexpression increases cytosolic catecholamine concentration

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18172548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI32806

1 reference

2329676

2329676

1 reference

1 reference

1 reference