Role of IL-15 and IL-21 in viral immunity: applications for vaccines and therapies (Q37386285)

20 August 2017

1 reference

title

Role of IL-15 and IL-21 in viral immunity: applications for vaccines and therapies (English)

1 reference

20 August 2017

Luiz Rodrigues

1

1 reference

PubMed ID

19196197

20 August 2017

Cristina Bonorino

series ordinal

2

1 reference

20 August 2017

1 February 2009

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Expert Review of Vaccines

20 August 2017

1 reference

20 August 2017

8

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20 August 2017

2

1 reference

20 August 2017

167-177

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Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways

20 August 2017

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin 9 and its receptor: an overview of structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Cytokine genetic adjuvant facilitates prophylactic intravascular DNA vaccine against acute and latent herpes simplex virus infection in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Control of CD4+ T-cell memory by cytokines and costimulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Homeostasis of memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

IL-7: maintaining T-cell memory and achieving homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Natural killer cell-dendritic cell crosstalk in the initiation of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Human immunodeficiency virus type 1 (HIV-1)-specific CD4+ T cells that proliferate in vitro detected in samples from most viremic subjects and inversely associated with plasma HIV-1 levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

CD8 T cell responses to infectious pathogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Cytokines and T-cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Herpesviruses and the innate immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Directed evolution of gene-shuffled IFN-alpha molecules with activity profiles tailored for treatment of chronic viral diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Antiviral CD4+ memory T cells are IL-15 dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin-21 inhibits dendritic cell activation and maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

A critical role for IL-21 in regulating immunoglobulin production

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Novel IL-15 isoforms generated by alternative splicing are expressed in the intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Toll-dependent control mechanisms of CD4 T cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Evaluation of toll-like receptor 4 gene expression of immortalized human liver cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Tracking dendritic cells in vivo: insights into DC biology and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Division of labor and cooperation between dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Dendritic cells prime natural killer cells by trans-presenting interleukin 15

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

IL-15 induces IFN-beta and iNOS gene expression, and antiviral activity of murine macrophage RAW 264.7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

CD8+ T cell efficacy in vaccination and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

A brief history of CD8 T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Prolonged exposure of naïve CD8+ T cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

EBV-associated mononucleosis leads to long-term global deficit in T-cell responsiveness to IL-15

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Immune regulation of viral infection and vice versa

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Viral persistence: parameters, mechanisms and future predictions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Immune control of herpes simplex virus during latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Latent virus influences the generation and maintenance of CD8+ T cell memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

CD8 T cell dysfunction during chronic viral infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Antigen-independent memory CD8 T cells do not develop during chronic viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Th17: the third member of the effector T cell trilogy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Development in motion: helper T cells at work

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

The molecular basis of IL-21-mediated proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation, and proliferation in CD8 T cells of patients with human immunodeficiency virus-1 (HIV)

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Comparison of immune responses induced in mice by vaccination with DNA vaccine constructs expressing mycobacterial antigen 85A and interleukin-21 and Bacillus Galmette-Guérin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

T cell priming by tissue-derived dendritic cells: new insights from recent murine studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Regulation of IL-21 signaling by suppressor of cytokine signaling-1 (SOCS1) in CD8(+) T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

CD27 is required for generation and long-term maintenance of T cell immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

The size and phenotype of virus-specific T cell populations is determined by repetitive antigenic stimulation and environmental cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Migration and differentiation of CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin-21 mRNA expression during virus infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Current progress of DNA vaccine studies in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

DNA vaccines and their applications in veterinary practice: current perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin-15 enhances the secretion of IFN-gamma and CC chemokines by natural killer cells from HIV viremic and aviremic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Efficient augmentation of a long-lasting immune responses in HIV-1 gag DNA vaccination by IL-15 plasmid boosting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

IL-2- and IL-15-induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin-21 signaling: functions in cancer and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

Interferons induce an antiviral state in human pancreatic islet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.8.2.167

21 January 2018

Identifiers

DOI

10.1586/14760584.8.2.167

1 reference

20 August 2017

1 reference

PubMed ID

19196197