IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response (Q24307467)

GOA release 2020-03-11

Interleukin 21

1 reference

tyrosine phosphorylation of STAT protein

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Mari Strengell

1

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Timo Sareneva

2

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Don Foster

3

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Ilkka Julkunen

4

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Sampsa Matikainen

Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells

5

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language of work or name

English

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publication date

1 October 2002

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published in

Journal of Immunology

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volume

169

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page(s)

3600-5

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issue

7

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cites work

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The molecular basis of natural killer (NK) cell recognition and function

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The cloning and characterization of human MyD88: a member of an IL-1 receptor related family

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Interleukin-12: a cytokine at the interface of inflammation and immunity

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Cytokines: IL-21 joins the gamma(c)-dependent network?

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Unresponsiveness of MyD88-deficient mice to endotoxin

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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

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7 January 2021

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

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The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements.

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

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7 January 2021

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

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Role of N-glycosylation in the synthesis, dimerization and secretion of human interferon-gamma.

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Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain

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Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15

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7 January 2021

Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling

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DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites

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Selective expression of an interleukin-12 receptor component by human T helper 1 cells

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7 January 2021

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

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Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells.

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A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

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Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

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Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene

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Natural killer cells in antiviral defense: function and regulation by innate cytokines

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Interleukin-18 regulates both Th1 and Th2 responses

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7 January 2021

Noncytolytic control of viral infections by the innate and adaptive immune response

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7 January 2021

The molecular cell biology of interferon-gamma and its receptor

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IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21

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7 January 2021

IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells

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Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection

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Differentiation of murine NK cells into distinct subsets based on variable expression of the IL-12R beta 2 subunit

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The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4.

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7 January 2021

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

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7 January 2021

Selective Expansion and Partial Activation of Human NK Cells and NK Receptor-Positive T Cells by IL-2 and IL-15

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7 January 2021