Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection. (Q33284533)

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title

Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection (English)

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1

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Antony J Cutler

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Stefan Magez

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Paul M Kaye

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Christoph Holscher

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Frank Brombacher

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author name string

J Claire Hoving

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Andreas Bohms

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Berenice Arendse

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Richard Kirsch

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Thomas Hunig

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James Alexander

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publication date

1 May 2007

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volume

3

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30 December 2019

page(s)

e68

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issue

5

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Creative Commons Attribution 4.0 International

30 December 2019

copyright license

start time

11 May 2007

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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21 June 2018

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31 October 2018

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31 October 2018

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31 October 2018

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31 October 2018

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The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4+CD25+ T cells.

31 October 2018

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31 October 2018

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Arginase I induction in macrophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites.

31 October 2018

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Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis

31 October 2018

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A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity.

31 October 2018

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Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling

31 October 2018

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Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses.

31 October 2018

1 reference

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IL-4-deficient Balb/c mice resist infection with Leishmania major

31 October 2018

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Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

31 October 2018

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Conditional gene targeting

31 October 2018

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IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity.

31 October 2018

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Early parasite containment is decisive for resistance to Leishmania major infection.

31 October 2018

1 reference

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Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling

31 October 2018

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Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile

10 December 2018

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12 December 2020

The role of IL-10 in promoting disease progression in leishmaniasis

1 reference

12 December 2020

IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice

1 reference

12 December 2020

Interleukin-10 inhibits antimicrobial activity against Leishmania major in murine macrophages

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12 December 2020

Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development

1 reference

12 December 2020

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones

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12 December 2020

Susceptibility to Leishmania major infection in interleukin-4-deficient mice

1 reference

12 December 2020

Effects of IL-13 on murine listeriosis

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12 December 2020

Interleukin-13 effects on activated monocytes lead to novel cytokine secretion profiles intermediate between those induced by interleukin-10 and by interferon-gamma

1 reference

12 December 2020

Cutting edge: IL-12 induces CD4+CD25- T cell activation in the presence of T regulatory cells

1 reference

12 December 2020

Cutting edge: IL-4-induced protection of CD4+CD25- Th cells from CD4+CD25+ regulatory T cell-mediated suppression

1 reference

12 December 2020

Lymph node resident rather than skin-derived dendritic cells initiate specific T cell responses after Leishmania major infection

1 reference

12 December 2020

CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice

1 reference

12 December 2020

The Relative Contribution of IL-4 Receptor Signaling and IL-10 to Susceptibility toLeishmania major

1 reference

12 December 2020

10.1371/JOURNAL.PPAT.0030068

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