Cyclosporin clinical pharmacokinetics (Q40918376)

24 September 2017

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title

Cyclosporin clinical pharmacokinetics (English)

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24 September 2017

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A Fahr

1

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24 September 2017

1 June 1993

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Clinical Pharmacokinetics

24 September 2017

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24 September 2017

24

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24 September 2017

472-495

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24 September 2017

6

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https://scigraph.springernature.com/pub.10.2165/00003088-199324060-00004

24 September 2017

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cites work

Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A.

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12 December 2020

Pathogenesis and management of lipoprotein disorders

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12 December 2020

Effect of bile on cyclosporin absorption in liver transplant patients

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12 December 2020

The impact of body weight on cyclosporine pharmacokinetics in renal transplant recipients

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12 December 2020

Individualization of cyclosporine therapy using pharmacokinetic and pharmacodynamic parameters

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12 December 2020

Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier

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12 December 2020

Significance of cyclosporine pharmacokinetics.

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12 December 2020

Cyclosporine and metabolites in blood from renal allograft recipients with nephrotoxicity, rejection, or good renal function: comparative high-performance liquid chromatography and monoclonal radioimmunoassay studies

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12 December 2020

Species-specific cyclosporine metabolism

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12 December 2020

Consensus document: Hawk's Cay meeting on therapeutic drug monitoring of cyclosporine

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12 December 2020

Restrictive transport of a lipid-soluble peptide (cyclosporin) through the blood-brain barrier.

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12 December 2020

Immunological and pharmacological monitoring in the clinical use of cyclosporin A

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12 December 2020

Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity

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12 December 2020

The pharmacokinetics of cyclosporine A in uremic patients

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12 December 2020

Time-dependent disposition of cyclosporine after pancreas transplantation, and application of chronopharmacokinetics to improve immunosuppression

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12 December 2020

Cyclosporin A-induced side effects in renal transplantation are related to the ratio of nonspecific/specific cyclosporin blood trough levels as analysed by radioimmunoassay

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12 December 2020

Clinical variability of cyclosporine pharmacokinetics in adult and pediatric patients after renal, cardiac, hepatic, and bone-marrow transplants.

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12 December 2020

Cyclosporine in autoimmune diseases

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12 December 2020

Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily

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12 December 2020

Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein

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12 December 2020

Different pharmacokinetics of cyclosporine A early and late after renal transplantation

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12 December 2020

Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size.

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12 December 2020

Central nervous system toxicity after liver transplantation. The role of cyclosporine and cholesterol.

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12 December 2020

Cyclosporin A in renal transplantation: a prospective randomized trial

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12 December 2020

Alterations in cyclosporine pharmacokinetics after renal transplantation are linked to rapid increases in hematocrit, lipoproteins, and serum protein

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12 December 2020

Use of a monoclonal antibody for the therapeutic monitoring of cyclosporine in plasma and whole blood

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12 December 2020

The insecticidal activity of cyclosporines on mosquito larvae

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12 December 2020

Consensus document: Hawk's Cay meeting on therapeutic drug monitoring of cyclosporine

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12 December 2020

Effect of short-term cyclosporine administration in rats on renin-angiotensin and thromboxane A2: possible relevance to the reduction in glomerular filtration rate

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12 December 2020

Cyclosporine: assay by HPLC and assay with monoclonal antibodies equivalent?

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12 December 2020

The kinetics of cyclosporine and its metabolites in bone marrow transplant patients

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12 December 2020

The use of cyclosporin A and prednisone in cadaver kidney transplantation

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12 December 2020

Pharmacokinetics of oral cyclosporin A (Sandimmun) in healthy subjects

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12 December 2020

Absorption profiles of renal allograft recipients receiving oral doses of cyclosporine: a pharmacokinetic study

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12 December 2020

Cyclosporine kinetics in healthy volunteers

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12 December 2020

The absorption site of cyclosporin in the human gastrointestinal tract

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12 December 2020

Problems with therapeutic monitoring of cyclosporine using silicone central venous line samples

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12 December 2020

Trough levels and concentration time curves of cyclosporine in patients undergoing renal transplantation

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12 December 2020

Physiologic modeling of cyclosporin kinetics in rat and man.

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12 December 2020

The presence of cyclosporine in body tissues and fluids during pregnancy

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12 December 2020

Acutely impaired renal function during intravenous administration of cyclosporine A: a cremophore side-effect

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12 December 2020

Cyclosporine pharmacokinetics in cats following topical ocular administration

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12 December 2020

Adverse reactions and interactions of cyclosporin

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12 December 2020

Cyclophilin: distribution and variant properties in normal and neoplastic tissues.

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12 December 2020

Pharmacokinetics and clinical tolerance of intravenous and oral cyclosporine in the immediate postoperative period

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12 December 2020

Intravenous cyclosporine and kidney function: the Johns Hopkins experience

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12 December 2020

Identification of cyclophilin as the erythrocyte ciclosporin-binding protein

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12 December 2020

The effect of food on cyclosporine absorption

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12 December 2020

Role of lipoproteins and erythrocytes in the in vitro binding and distribution of cyclosporin A in the blood

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12 December 2020

Interaction between cyclosporin and erythromycin in a kidney transplant patient

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12 December 2020

Effect of hematocrit on cyclosporine (cyclosporin A) in whole blood and plasma of renal-transplant patients

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12 December 2020

Comparison of methods to calculate cyclosporine A bioavailability from consecutive oral and intravenous doses

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12 December 2020

The effect of vehicle on the oral absorption of cyclosporin.

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12 December 2020

Identification of the Aldehydic Metabolites

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12 December 2020

Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA.

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12 December 2020

Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders

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12 December 2020

High-fat meals increase the clearance of cyclosporine

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12 December 2020

Liver transplantation today

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12 December 2020

Photoaffinity labeling of membrane proteins from rat liver and pig kidney with cyclosporine diazirine. Involvement of binding to plasma membranes cytotoxic effects

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12 December 2020

Disposition of cyclosporine in several animal species and man. I. Structural elucidation of its metabolites

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12 December 2020

The effect of cyclosporine administration on the cellular distribution and content of cyclophilin

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12 December 2020

A review of assay methods for cyclosporin. Clinical implications

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12 December 2020

NEUROLOGICAL COMPLICATIONS FOLLOWING LIVER TRANSPLANTATION

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12 December 2020

Intravenous cyclosporine kinetics in renal failure

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12 December 2020

Temperature dependency of apparent cyclosporin A concentrations in plasma

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12 December 2020

Studies of cyclosporine blood levels: analysis, clinical utility, pharmacokinetics, metabolites, and chronopharmacology

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12 December 2020

The pharmacokinetics of cyclosporine. I. Single dose and constant rate infusion studies in the rabbit

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12 December 2020

Biological effects of cyclosporin A: A new antilymphocytic agent

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12 December 2020

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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12 December 2020

The contrasting effects of cyclosporin-A and azathioprine on arterial blood pressure and renal function following cardiac transplantation

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12 December 2020

Cyclosporine A monitoring by radioimmunoassay (RIA) and high-performance liquid chromatography (HPLC) after liver transplantation: influence of route of administration and of liver function on the RIA:HPLC ratio

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12 December 2020

Area under the curve monitoring of cyclosporine therapy: the early posttransplant period.

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12 December 2020

Cyclosporine nephrotoxicity is minimized by adjusting dosage on the basis of drug concentration in blood

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12 December 2020

Concentrations of cyclosporin A and its metabolites in human tissues postmortem.

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12 December 2020

Diurnal variation in cyclosporine kinetics

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12 December 2020

Distribution of cyclosporin A metabolites among plasma and cells in whole blood: effect of temperature, hematocrit, and metabolite concentration

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12 December 2020

Age-dependent cyclosporine: pharmacokinetics in marrow transplant recipients

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12 December 2020

A sulfate conjugate of cyclosporin

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12 December 2020

Pharmacokinetic profiles of cyclosporine in rats. Influence of route of administration and dosage.

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12 December 2020

The chronopharmacokinetics of cyclosporine and its metabolites in recipients of pancreas allografts

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12 December 2020

Blood cyclosporin concentrations and renal allograft dysfunction

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12 December 2020

Pharmacokinetic evaluation of the blood-to-lymph transfer of cyclosporin A in rats

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12 December 2020

Studies on the biologic activities of Sandimmun metabolites in humans and in animal models: review and original experiments

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12 December 2020

Cyclosporin: measurement of fraction unbound in plasma

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12 December 2020

Optimization of cyclosporine therapy in renal transplantation by a pharmacokinetic strategy

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12 December 2020

Cyclosporine-associated nephrotoxicity is not intractable

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12 December 2020

Cyclosporine determinations in heart and kidney transplant patients: comparison of high-performance liquid chromatography, polyclonal, and monoclonal methods

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12 December 2020

Cyclosporin radioimmunoassay and cardiac transplantation

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12 December 2020

Cyclosporine Metabolite Profiles in the Blood of Liver Transplant Patients.

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12 December 2020

Pharmacokinetics of cyclosporine in solid organ transplantation

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12 December 2020

Effect of age on cyclosporine pharmacokinetics in marrow transplant recipients

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12 December 2020

Blood cyclosporine pharmacokinetics in patients undergoing marrow transplantation. Influence of age, obesity, and hematocrit

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12 December 2020

Erythromycin enhances the absorption of cyclosporin

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12 December 2020

Cyclosporine metabolites in human blood and renal tissue

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12 December 2020

Measurements of cyclosporine A by RIA in different centers are not comparable

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12 December 2020

Cyclosporin metabolism by the gastrointestinal mucosa

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12 December 2020

Oral administration of cyclosporin A for recipients of allogeneic marrow transplants: implications of clinical gut dysfunction

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12 December 2020

Chemistry of the natural cyclosporin metabolites.

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12 December 2020

Cyclosporine A administration: once a day or in fractional doses?

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12 December 2020

Cyclosporine kinetics in renal transplant patients as assessed by high-performance liquid chromatography and radioimmunoassay using monoclonal and polyclonal antibodies

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12 December 2020

Biological and pharmaceutical factors affecting the absorption and lymphatic delivery of ciclosporin A from gastrointestinal tract

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12 December 2020

Metabolism of cyclosporine

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12 December 2020

Isolation, purification and structure elucidation of cyclosporin A metabolites in rabbit and man

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12 December 2020

Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration

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12 December 2020

A case of accidental cyclosporin overdose with pharmacokinetic analysis

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12 December 2020

Comment on cyclosporine assay techniques: an attempt for recommendations

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12 December 2020

Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients

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12 December 2020

The ability of pretransplant test-dose pharmacokinetic profiles to reduce early adverse events after renal transplantation

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12 December 2020

Cyclosporine and its metabolites in mother and baby

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12 December 2020

An acid metabolite of cyclosporine

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12 December 2020

Distribution of the cyclosporine binding protein cyclophilin in human tissues

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12 December 2020

Effects of cyclosporine on the isolated perfused rat kidney

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12 December 2020

Structures of cyclosporine and its metabolites

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12 December 2020

Interaction of cyclosporin A with human lipoproteins.

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12 December 2020

Cyclosporine monitoring by fluorescence polarization immunoassay

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12 December 2020

Abbreviated kinetic profiles in area-under-the-curve monitoring of cyclosporine therapy.

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12 December 2020

Management of drug interactions with cyclosporine

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12 December 2020

Measurement of cyclosporine and 18 metabolites in blood, bile, and urine by high-performance liquid chromatography

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12 December 2020

Cyclosporin A and Trichinella spiralis: anthelminthic effects in immunosuppressed mice

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12 December 2020

Clinical pharmacokinetics of cyclosporin

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12 December 2020

The effects and side effects of cyclosporine: relationship to drug pharmacokinetics

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12 December 2020

Therapeutic monitoring of cyclosporin ? an update

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12 December 2020

Intestinal lymphatic absorption of cyclosporin A following oral administration in an olive oil solution in rats

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12 December 2020

First-pass metabolism of cyclosporin by the gut

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12 December 2020

Progress towards a molecular understanding of cyclosporin A-mediated immunosuppression

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12 December 2020

Cyclosporin-phenytoin interaction: re-evaluation using metabolite data

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12 December 2020

Saturable binding of cyclosporin A to erythrocytes: estimation of binding parameters in renal transplant patients and implications for bioavailability assessment

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12 December 2020

The clearance of cyclosporine by hemodialysis

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12 December 2020

Assessment of cyclosporine A interactions with human plasma lipoproteins in vitro and in vivo in the rat.

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12 December 2020

Binding of cyclosporine by human lymphocytes and phospholipid vesicles

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12 December 2020

The effect of food and bile acid administration on the relative bioavailability of cyclosporin

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12 December 2020

Effect of obesity on cyclosporine disposition

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12 December 2020

Investigations on the metabolic pathways of cyclosporine: I. Excretion of cyclosporine and its metabolites in human bile—isolation of 12 new cyclosporine metabolites

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12 December 2020

Absorption of cyclosporine A after oral dosing

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12 December 2020

Pharmacokinetic drug interactions with cyclosporin (Part I).

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12 December 2020

Evaluation of cyclosporin-phenytoin interaction with observations on cyclosporin metabolites

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12 December 2020

Cyclosporine absorption following orthotopic liver transplantation

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12 December 2020

The effect of oral metoclopramide on the absorption of cyclosporine

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12 December 2020

Critical issues in cyclosporine monitoring: report of the Task Force on Cyclosporine Monitoring

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12 December 2020

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

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12 December 2020

Influence of demographic factors on cyclosporine pharmacokinetics in adult uremic patients

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12 December 2020

Demographic factors affecting the pharmacokinetics of cyclosporine estimated by radioimmunoassay

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12 December 2020

The role of drug metabolism in cyclosporine A nephrotoxicity

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12 December 2020

Cyclosporine, low-density lipoprotein, and cholesterol

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12 December 2020

Cyclosporine: structure, pharmacokinetics, and therapeutic drug monitoring

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12 December 2020

Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs.

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12 December 2020

Crystal and molecular structure of an iodo-derivative of the cyclic undecapeptide cyclosporin A.

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12 December 2020

Renal side-effects of cyclosporin A.

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12 December 2020

On the dose dependency of cyclosporin A absorption and disposition in healthy volunteers

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12 December 2020

Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers

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12 December 2020

Biotransformation and distribution in blood of cyclosporine and its metabolites

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12 December 2020

Ciclosporin metabolite pattern in blood and urine of liver graft recipients. I. Association of ciclosporin metabolites with nephrotoxicity

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12 December 2020

Cyclosporin A in patients receiving renal allografts from cadaver donors

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12 December 2020

Cyclosporine pharmacokinetics in uremic patients: influence of different assay methods

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12 December 2020

Intraindividual variability in the relative systemic availability of cyclosporin after oral dosing

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12 December 2020

10.2165/00003088-199324060-00004

Identifiers

DOI

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PubMed ID

8513650

Dimensions Publication ID

24 September 2017

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PubMed ID

8513650