Pharmacogenetic insights into codeine analgesia: implications to pediatric codeine use. (Q37264538)

19 August 2017

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title

Pharmacogenetic insights into codeine analgesia: implications to pediatric codeine use. (English)

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19 August 2017

2

Gideon Koren

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19 August 2017

Parvaz Madadi

1

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19 August 2017

1 September 2008

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19 August 2017

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19 August 2017

9

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19 August 2017

9

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19 August 2017

1267-1284

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Infant and neonatal pain: anaesthetists' perceptions and prescribing patterns

19 August 2017

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Unlicensed and off label analgesic use in paediatric pain management

21 January 2018

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Codeine phosphate in paediatric medicine

21 January 2018

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Mu receptor binding of some commonly used opioids and their metabolites

21 January 2018

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Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers

21 January 2018

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Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquine

21 January 2018

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Analgesic effects of codeine-6-glucuronide after intravenous administration

21 January 2018

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Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites

21 January 2018

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Identification of hydrocodone in human urine following controlled codeine administration

21 January 2018

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The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine.

21 January 2018

1 reference

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Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7.

21 January 2018

1 reference

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Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers

21 January 2018

1 reference

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Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners

21 January 2018

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Developmental pharmacology--drug disposition, action, and therapy in infants and children

21 January 2018

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Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

21 January 2018

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Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects

21 January 2018

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Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers

21 January 2018

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The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype

21 January 2018

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Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication.

21 January 2018

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Codeine intoxication associated with ultrarapid CYP2D6 metabolism

21 January 2018

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Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

21 January 2018

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Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer

21 January 2018

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CYP2D6 genotyping and codeine

21 January 2018

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Re: Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer [corrected].

21 January 2018

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Codeine induced respiratory depression in a child

21 January 2018

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Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives

21 January 2018

1 reference

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Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer.

21 January 2018

1 reference

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Differential foetal development of the O- and N-demethylation of codeine and dextromethorphan in man

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Developmental changes in human liver CYP2D6 expression.

21 January 2018

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Expression of CYP2D6 in developing human liver

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children

21 January 2018

1 reference

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Ontogeny of dextromethorphan O- and N-demethylation in the first year of life

21 January 2018

1 reference

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Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants.

21 January 2018

1 reference

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Development of CYP2D6 and CYP3A4 in the first year of life

21 January 2018

1 reference

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Comparative cytochrome P450 -1A1, -2A6, -2B6, -2C, -2D6, -2E1, -3A5 and -4B1 expressions in human larynx tissue analysed at mRNA level.

21 January 2018

1 reference

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Drug metabolism enzyme expression and activity in primary cultures of human proximal tubular cells

21 January 2018

1 reference

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Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain

21 January 2018

1 reference

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Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics.

21 January 2018

1 reference

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CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?

21 January 2018

1 reference

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Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Predicting response to lithium in mood disorders: role of genetic polymorphisms

21 January 2018

1 reference

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A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine

21 January 2018

1 reference

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Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Clinical response to morphine in cancer patients and genetic variation in candidate genes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Pharmacokinetics and drug distribution during postnatal development

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Morphine metabolism in children

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Glucuronidation in humans. Pharmacogenetic and developmental aspects

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms

21 January 2018

1 reference

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Developmental aspects of human hepatic drug glucuronidation in young children and adults

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Epirubicin glucuronidation and UGT2B7 developmental expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Pharmacogenetics of opioids

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Pharmacokinetic consequences of active drug efflux at the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Carrier-mediated processes at several rat brain interfaces determine the neuropharmacokinetics of morphine and morphine-6-beta-D-glucuronide

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Effect of P-glycoprotein modulation on the clinical pharmacokinetics and adverse effects of morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Identification of functionally variant MDR1 alleles among European Americans and African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brain

21 January 2018

1 reference

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Blood-Brain Barrier: Penetration of Morphine, Codeine, Heroin, and Methadone after Carotid Injection

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Postoperative morphine infusion in newborn infants: assessment of disposition characteristics and safety.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Disposition of morphine in plasma and cerebrospinal fluid varies during neonatal development in pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Postoperative pain in the neonate: age-related differences in morphine requirements and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of children

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Opiate-induced respiratory depression in pediatric patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

P-glycoprotein and bilirubin disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Pharmacogenetics of opioid receptors and addiction

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.

21 January 2018

1 reference

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The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

21 January 2018

1 reference

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Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor

21 January 2018

1 reference

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A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling

21 January 2018

1 reference

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The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers

21 January 2018

1 reference

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Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene

21 January 2018

1 reference

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Polymorphism of mu-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.9.1267

Effects of prenatal cocaine, morphine, or both on postnatal opioid (mu) receptor development

21 January 2018

1 reference

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COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor

21 January 2018

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Cloning and Characterization of Human Placental Catechol--Methyltransferase cDNA

21 January 2018

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Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form

21 January 2018

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The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients

21 January 2018

1 reference

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Developmental regulation of codeine analgesia in the rat.

21 January 2018

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Codeine intoxication in childhood

21 January 2018

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Are one or two dangerous? Opioid exposure in toddlers

21 January 2018

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Adverse effects following the inadvertent administration of opioids to infants and children

21 January 2018

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Codeine intoxication in the neonate

21 January 2018

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Guidelines for evaluating chronic cough in pediatrics: ACCP evidence-based clinical practice guidelines

21 January 2018

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Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication

21 January 2018

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Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability

21 January 2018

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The effect of CYP2D6 polymorphisms on the response to pain treatment for pediatric sickle cell pain crisis

21 January 2018

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Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes

21 January 2018

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CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans

21 January 2018

1 reference

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Environmental and genetic factors associated with morphine response in the postoperative period

21 January 2018

1 reference

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10.2217/14622416.9.9.1267

21 January 2018

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

18781855