Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine (Q37230991)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26385075%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine (English)

1 reference

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24 February 2020

1 reference

invasive ductal carcinoma

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pancreatic ductal adenocarcinoma

inferred from title

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pancreatic ductal carcinoma

inferred from title

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1 reference

2

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24 February 2020

author name string

Erik S Knudsen

series ordinal

1

1 reference

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24 February 2020

Jonathan R Brody

series ordinal

3

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24 February 2020

Agnieszka K Witkiewicz

series ordinal

4

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24 February 2020

language of work or name

English

0 references

publication date

15 September 2015

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24 February 2020

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24 February 2020

volume

150

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24 February 2020

issue

1

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24 February 2020

page(s)

48-63

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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

24 February 2020

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6 September 2017

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6 September 2017

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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

6 September 2017

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Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers

6 September 2017

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CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers

6 September 2017

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Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas.

6 September 2017

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Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

6 September 2017

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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

6 September 2017

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ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells

6 September 2017

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Genetic susceptibility to pancreatic cancer

6 September 2017

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6 September 2017

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6 September 2017

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MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells.

6 September 2017

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6 September 2017

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Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development

6 September 2017

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6 September 2017

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FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

6 September 2017

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GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

6 September 2017

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Notch signalling in solid tumours: a little bit of everything but not all the time

6 September 2017

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MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts

6 September 2017

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Distant metastasis occurs late during the genetic evolution of pancreatic cancer

6 September 2017

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Stromal biology and therapy in pancreatic cancer.

6 September 2017

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6 September 2017

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SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer

6 September 2017

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DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.

6 September 2017

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Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

6 September 2017

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Drug resistance caused by reversion mutation

6 September 2017

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

6 September 2017

1 reference

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Stabilization of beta-catenin induces pancreas tumor formation

6 September 2017

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Targeted therapy for cancer using PARP inhibitors

6 September 2017

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A syngeneic variance library for functional annotation of human variation: application to BRCA2

6 September 2017

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A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

6 September 2017

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6 September 2017

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Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

6 September 2017

1 reference

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Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

6 September 2017

1 reference

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Ductal pancreatic cancer in humans and mice.

6 September 2017

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In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Functional defects in the fanconi anemia pathway in pancreatic cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Pancreatic cancer biology and genetics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Progression model for pancreatic cancer.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: A newly described and characterized entity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Pancreatic adenocarcinomas frequently show p53 gene mutations.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Pancreaticoduodenectomy for cancer of the head of the pancreas. 201 patients

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

A human Mad protein acting as a BMP-regulated transcriptional activator

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Molecular advances in pancreatic cancer

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Detection of mutated ras-oncogene in pancreatic cancers: improved diagnostic possibilities using molecular biology techniques?

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Phase I study of olaparib plus gemcitabine in patients with advanced solid tumours and comparison with gemcitabine alone in patients with locally advanced/metastatic pancreatic cancer.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

US National Cancer Institute's new Ras project targets an old foe.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

A phase II open-label randomized study to assess the efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Serum CA19-9 response as a surrogate for clinical outcome in patients receiving fixed-dose rate gemcitabine for advanced pancreatic cancer

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

CDKN2A germline mutations in familial pancreatic cancer

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5010785

Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas

3 September 2018

1 reference

12 December 2020

Pathologic examination accurately predicts prognosis in mucinous cystic neoplasms of the pancreas

1 reference

12 December 2020

Fanconi anemia gene mutations in young-onset pancreatic cancer

1 reference

12 December 2020

Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt

1 reference

12 December 2020

Molecular genetics of colorectal cancer

1 reference

12 December 2020

A 67-year-old woman with BRCA 1 mutation associated with pancreatic adenocarcinoma

1 reference

12 December 2020

Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes

1 reference

12 December 2020

p53 and K-RAS alterations in pancreatic epithelial cell lesions

1 reference

12 December 2020

Adenosquamous Carcinoma Of The Pancreas: A Clinicopathologic Series Of 25 Cases

1 reference

12 December 2020

Molecular analysis for therapy choice: NCI MATCH

1 reference

12 December 2020

Advancements in the management of pancreatic cancer: 2013

1 reference

12 December 2020

10.1053/J.GASTRO.2015.08.056

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26385075%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26385075%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference