TCF7L2 genetic defect and type 2 diabetes (Q37150525)

18 August 2017

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title

TCF7L2 genetic defect and type 2 diabetes (English)

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18 August 2017

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2

Philippe Froguel

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author name string

Stéphane Cauchi

series ordinal

1

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PubMed ID

18445358

18 August 2017

language of work or name

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1 April 2008

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18 August 2017

Current diabetes report

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18 August 2017

8

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18 August 2017

2

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18 August 2017

149-155

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https://scigraph.springernature.com/pub.10.1007/s11892-008-0026-x

18 August 2017

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cites work

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

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12 December 2020

No Evidence of Association of ENPP1 Variants With Type 2 Diabetes or Obesity in a Study of 8,089 U.K. Caucasians

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12 December 2020

TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study

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12 December 2020

The replication of beta cells in normal physiology, in disease and for therapy

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12 December 2020

Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women

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12 December 2020

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

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12 December 2020

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

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12 December 2020

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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12 December 2020

The Yin-Yang of TCF/beta-catenin signaling

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12 December 2020

E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant.

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12 December 2020

Association of the APC tumor suppressor protein with catenins

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12 December 2020

Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample

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12 December 2020

Effects of TCF7L2 polymorphisms on obesity in European populations

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12 December 2020

Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese

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12 December 2020

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

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12 December 2020

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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12 December 2020

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human -Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

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12 December 2020

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

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12 December 2020

A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population

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12 December 2020

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

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12 December 2020

A second generation human haplotype map of over 3.1 million SNPs

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12 December 2020

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12 December 2020

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

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12 December 2020

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

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12 December 2020

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

1 reference

12 December 2020

Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys

1 reference

12 December 2020

Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.

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12 December 2020

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface

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12 December 2020

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

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12 December 2020

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

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12 December 2020

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

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12 December 2020

Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort

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12 December 2020

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

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12 December 2020

Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function

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Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001

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12 December 2020

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

1 reference

12 December 2020

Effects of the diabetes linked TCF7L2 polymorphism in a representative older population

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12 December 2020

Association Analysis of 6,736 U.K. Subjects Provides Replication and ConfirmsTCF7L2as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk

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12 December 2020

Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans

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12 December 2020

The Wnt signaling pathway in development and disease

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12 December 2020

Association of the APC gene product with beta-catenin

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12 December 2020

Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis

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How many genes underlie the occurrence of common complex diseases in the population?

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A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

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12 December 2020

The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines

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12 December 2020

TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden

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12 December 2020

The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3

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12 December 2020

Common variants in HNF-1 alpha and risk of type 2 diabetes

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12 December 2020

Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity

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12 December 2020

Predictive genetic testing for type 2 diabetes

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12 December 2020

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

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12 December 2020

Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids

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12 December 2020

Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

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12 December 2020

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

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12 December 2020

Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes

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12 December 2020

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

1 reference

12 December 2020

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

1 reference

12 December 2020

Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway.

1 reference

12 December 2020

Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population

1 reference

12 December 2020

A genome-wide association study identifies novel risk loci for type 2 diabetes

1 reference

12 December 2020

The enteroinsular axis may mediate the diabetogenic effects of TCF7L2 polymorphisms

1 reference

12 December 2020

Association Study of the Genetic Polymorphisms of the Transcription Factor 7-Like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population

1 reference

12 December 2020

Regulation of Wnt signaling during adipogenesis

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12 December 2020

Hedgehog signaling regulation of insulin production by pancreatic beta-cells

1 reference

12 December 2020

TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population

1 reference

12 December 2020

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.

1 reference

12 December 2020

No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects

1 reference

12 December 2020

Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians

1 reference

12 December 2020

A Large-Scale Association Analysis of Common Variation of the HNF1 Gene With Type 2 Diabetes in the U.K. Caucasian Population

1 reference

12 December 2020

IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies

1 reference

12 December 2020

Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans

1 reference

12 December 2020

Inhibition of adipogenesis by Wnt signaling

1 reference

12 December 2020

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

1 reference

12 December 2020

Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men

1 reference

12 December 2020

Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses

1 reference

12 December 2020

Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility

1 reference

12 December 2020

Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals

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12 December 2020

SDF1alpha/CXCR4 signaling stimulates beta-catenin transcriptional activity in rat neural progenitors

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12 December 2020

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

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12 December 2020

Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.

1 reference

12 December 2020

Functional interaction of beta-catenin with the transcription factor LEF-1

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12 December 2020

Wnt/beta-catenin signaling in development and disease

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12 December 2020

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

1 reference

12 December 2020

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

1 reference

12 December 2020

TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

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12 December 2020

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

1 reference

12 December 2020

10.1007/S11892-008-0026-X

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18445358