Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders (Q37143117)

18 August 2017

1 reference

title

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders (English)

1 reference

18 August 2017

1 reference

3

John H Krystal

1 reference

18 August 2017

1

Gerard Sanacora

1 reference

18 August 2017

Carlos A Zarate

2

1 reference

PMCID

2715836

18 August 2017

Husseini K Manji

series ordinal

4

1 reference

18 August 2017

1 May 2008

1 reference

Nature Reviews Drug Discovery

18 August 2017

1 reference

18 August 2017

7

1 reference

18 August 2017

426-437

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18 August 2017

5

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd2462

18 August 2017

0 references

cites work

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder

6 September 2017

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6 September 2017

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Effects of D-cycloserine on extinction: translation from preclinical to clinical work

6 September 2017

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A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

6 September 2017

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Astrocyte control of synaptic transmission and neurovascular coupling.

6 September 2017

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Neural circuitry and neuroplasticity in mood disorders: insights for novel therapeutic targets

6 September 2017

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The role of glutamate in anxiety and related disorders

6 September 2017

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Beyond monoamines: glutamatergic function in mood disorders

6 September 2017

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Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice

6 September 2017

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Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression

6 September 2017

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Inhibitor of the glutamate vesicular transporter (VGLUT).

6 September 2017

1 reference

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A brief overview of the clinical pharmacology of "club drugs".

6 September 2017

1 reference

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Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data

6 September 2017

1 reference

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Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Glutamate in CNS disorders as a target for drug development: an update

6 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

6 September 2017

Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

An open-label trial of riluzole in patients with treatment-resistant major depression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Regulation of cellular plasticity cascades in the pathophysiology and treatment of mood disorders: role of the glutamatergic system

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Physiological roles and therapeutic potential of metabotropic glutamate receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

In vivo 1H-[13C]-NMR spectroscopy of cerebral metabolism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

The McLean-Harvard First-Episode Mania Study: Prediction of Recovery and First Recurrence

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Glutamate uptake by oligodendrocytes: Implications for excitotoxicity in multiple sclerosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Glutamatergic systems in Alzheimer's disease.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Chronic elevation of brain-derived neurotrophic factor by ampakines

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Modulators of the glutamatergic system: implications for the development of improved therapeutics in mood disorders

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Timing is everything: does the robust upregulation of noradrenergically regulated plasticity genes underlie the rapid antidepressant effects of sleep deprivation?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

The origin and neuronal function of in vivo nonsynaptic glutamate.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac).

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

The cellular neurobiology of depression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Neuroplasticity and cellular resilience in mood disorders

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Increased cerebrospinal fluid glutamine levels in depressed patients

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Antidepressant effects of ketamine in depressed patients

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Glial reduction in the subgenual prefrontal cortex in mood disorders

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Lithium stimulates glutamate "release" and inositol 1,4,5-trisphosphate accumulation via activation of the N-methyl-D-aspartate receptor in monkey and mouse cerebral cortex slices

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Functional antagonists at the NMDA receptor complex exhibit antidepressant actions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Metabolism and role of glutamate in mammalian brain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

The chemical nature of the main central excitatory transmitter: a critical appraisal based upon release studies and synaptic vesicle localization

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Inhibition of N-methyl-l-aspartate activated ion current by desmethylimipramine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Brain amino acid concentrations and Ca2+-dependent release in intractable depression assessed antemortem

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Is cocaine desire reduced by N-acetylcysteine?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Effects of combined lamotrigine and valproate on basal and stimulated extracellular amino acids and monoamines in the hippocampus of freely moving rats

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Riluzole enhances glutamate uptake in rat astrocyte cultures

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Effects of riluzole on electrically evoked neurotransmitter release

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Adaptation of cortical NMDA receptors by chronic treatment with specific serotonin reuptake inhibitors.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Repeated ECS induces GluR1 mRNA but not NMDAR1A-G mRNA in the rat hippocampus.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Lithium stimulates accumulation of second-messenger inositol 1,4,5-trisphosphate and other inositol phosphates in mouse pancreatic minilobules without inositol supplementation

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Open channel block of NMDA receptor responses evoked by tricyclic antidepressants

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Valproate suppresses N-methyl-D-aspartate-evoked, transient depolarizations in the rat neocortex in vitro

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Functional impairment in the remission phase of bipolar disorder.

27 June 2018

1 reference

Evidence-Based Health Policy---Lessons from the Global Burden of Disease Study

21 January 2018

1 reference

The long-term natural history of the weekly symptomatic status of bipolar I disorder

21 January 2018

1 reference

Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone.

21 January 2018

1 reference

Localization of VGLUT3, the vesicular glutamate transporter type 3, in the rat brain

21 January 2018

1 reference

Plasma and platelet excitatory amino acids in psychiatric disorders.

21 January 2018

1 reference

Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.

21 January 2018

1 reference

Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment-resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity.

21 January 2018

1 reference

Increased levels of glutamate in brains from patients with mood disorders.

21 January 2018

1 reference

Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses.

21 January 2018

1 reference

The NR1 subunit of the glutamate/NMDA receptor in the superior temporal cortex in schizophrenia and affective disorders

21 January 2018

1 reference

Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder

21 January 2018

1 reference

N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels.

21 January 2018

1 reference

Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder

21 January 2018

1 reference

Lamina-specific abnormalities of AMPA receptor trafficking and signaling molecule transcripts in the prefrontal cortex in schizophrenia.

21 January 2018

1 reference

Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression

21 January 2018

1 reference

Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder

21 January 2018

1 reference

NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder

21 January 2018

1 reference

Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes.

21 January 2018

1 reference

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression.

21 January 2018

1 reference

Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder.

21 January 2018

1 reference

Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder

21 January 2018

1 reference

Immunohistochemical localization of phosphorylated glial fibrillary acidic protein in the prefrontal cortex and hippocampus from patients with schizophrenia, bipolar disorder, and depression.

21 January 2018

1 reference

Low glial numbers in the amygdala in major depressive disorder

21 January 2018

1 reference

Glial fibrillary acidic protein and glutamine synthetase in subregions of prefrontal cortex in schizophrenia and mood disorder.

21 January 2018

1 reference

Antidepressant treatments and function of glutamate ionotropic receptors mediating amine release in hippocampus.

21 January 2018

1 reference

Differential effects of kindled and electrically induced seizures on a glutamate receptor (GluR1) gene expression.

21 January 2018

1 reference

Regulation of editing and expression of glutamate alpha-amino-propionic-acid (AMPA)/kainate receptors by antidepressant drugs.

21 January 2018

1 reference

A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group

21 January 2018

1 reference

Structurally dissimilar antimanic agents modulate synaptic plasticity by regulating AMPA glutamate receptor subunit GluR1 synaptic expression

21 January 2018

1 reference

The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders.

21 January 2018

1 reference

An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression

21 January 2018

1 reference

The partial NMDA agonist D-cycloserine stimulates LH secretion in healthy volunteers.

21 January 2018

1 reference

Behavioral and neuroendocrine effects of the partial NMDA agonist D-cycloserine in healthy subjects.

21 January 2018

1 reference

A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder.

21 January 2018

1 reference

Memantine in moderate-to-severe Alzheimer's disease

21 January 2018

1 reference

An open-label, flexible-dose study of memantine in major depressive disorder.

21 January 2018

1 reference

Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors.

21 January 2018

1 reference

The schizophrenia ketamine challenge study debate.

21 January 2018

1 reference

Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model

21 January 2018

1 reference

Antidepressant-like actions of an AMPA receptor potentiator (LY392098).

21 January 2018

1 reference

Chronic AMPA receptor potentiator (LY451646) treatment increases cell proliferation in adult rat hippocampus

21 January 2018

1 reference

In vitro and antinociceptive profile of HON0001, an orally active NMDA receptor NR2B subunit antagonist.

21 January 2018

1 reference

Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides.

21 January 2018

1 reference

Amyotrophic lateral sclerosis--a new role for old drugs

21 January 2018

1 reference

Medicine. Treating neurodegenerative diseases with antibiotics.

21 January 2018

1 reference

Antidepressant-like effects of ceftriaxone in male C57BL/6J mice.

21 January 2018

1 reference

Glia mechanisms in mood regulation: a novel model of mood disorders.

21 January 2018

1 reference

AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

21 January 2018

1 reference

Chronic antidepressants reduce depolarization-evoked glutamate release and protein interactions favoring formation of SNARE complex in hippocampus.

21 January 2018

1 reference

NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo.

21 January 2018

1 reference

N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder.

21 January 2018

1 reference

Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons.

21 January 2018

1 reference

How can drug discovery for psychiatric disorders be improved?

21 January 2018

1 reference

Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain. A quantitative in situ hybridization study.

21 January 2018

1 reference

Selective cortical VGLUT1 increase as a marker for antidepressant activity

21 January 2018

1 reference

Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment

21 January 2018

1 reference

Lithium modulates desensitization of the glutamate receptor subtype gluR3 in Xenopus oocytes.

21 January 2018

1 reference

Valproic acid reduces enhanced vesicular glutamate transporter immunoreactivities in the dentate gyrus of the seizure prone gerbil

21 January 2018

1 reference

Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro.

21 January 2018

1 reference

Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate

21 January 2018

1 reference

The effects of aging on spinal neurochemistry in the rat.

21 January 2018

1 reference

Inhibition of [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid [AMPA] binding by the anticonvulsant valproate in clinically relevant concentrations: an autoradiographic investigation in human hippocampus.

21 January 2018

1 reference

Chronic lithium chloride administration attenuates brain NMDA receptor-initiated signaling via arachidonic acid in unanesthetized rats.

21 January 2018

1 reference

A double-blind, placebo-controlled study of memantine in the treatment of major depression.

21 January 2018

1 reference

Searching for rational anti N-methyl-D-aspartate treatment for depression.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Identification of the differentiation-associated Na+/PI transporter as a novel vesicular glutamate transporter expressed in a distinct set of glutamatergic synapses.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

AMPA receptors: molecular and functional diversity.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Intravenous ketamine for pediatric sedation in the emergency department: safety profile with 156 cases.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Modulation of the seizure threshold for excitatory amino acids in mice by antiepileptic drugs and chemoconvulsants.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

The N-methyl-D-aspartate receptor complex. Various sites of regulation and clinical consequences

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715836

Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression

3 September 2018

1 reference

Increased serum glutamate in depressed patients

21 January 2018

1 reference

Plasma and platelet amino acid concentrations in patients affected by major depression and under fluvoxamine treatment

31 March 2020

1 reference

Correlation between plasma levels of glutamate, alanine and serine with severity of depression

31 March 2020

1 reference

Alterations in the N-methyl-d-asparatate (NMDA) receptor complex in the frontal cortex of suicide victims

31 March 2020

1 reference

Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder

31 March 2020

1 reference

A novel action of lithium: stimulation of glutamate release and inositol 1,4,5 trisphosphate accumulation via activation of the N-methyl D-aspartate receptor in monkey and mouse cerebral cortex slices

31 March 2020

1 reference

Cyloserine as an antidepressant agent

31 March 2020

1 reference

Memantine may acutely improve cognition and have a mood stabilizing effect in treatment-resistant bipolar disorder

31 March 2020

1 reference

Neuropharmacology of AMPA and kainate receptors

31 March 2020

1 reference

Antidepressants and gene expression profiling: how to SNARE novel drug targets

31 March 2020

1 reference

Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex--a possible mechanism of neuroprotection in major depression?

31 March 2020

1 reference

Tricyclic antidepressants, but not the selective serotonin reuptake inhibitor fluoxetine, bind to the S1S2 domain of AMPA receptors

31 March 2020

1 reference

Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis

31 March 2020

1 reference

Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18425072

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD2462

1 reference

18 August 2017

1 reference

18 August 2017

1 reference

PMCID

2715836