Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain (Q40709452)

23 September 2017

1 reference

title

Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain (English)

1 reference

23 September 2017

W Löscher

1

1 reference

23 September 2017

1 April 1993

1 reference

23 September 2017

Neurochemical Research

1 reference

23 September 2017

18

1 reference

23 September 2017

4

1 reference

23 September 2017

485-502

1 reference

https://scigraph.springernature.com/pub.10.1007/bf00967253

23 September 2017

0 references

cites work

Comparison of the structural characteristics of the 4-aminobutyrate:2-oxoglutarate transaminases from rat and human brain, and of their affinities for certain inhibitors

1 reference

https://api.crossref.org/works/10.1007%2FBF00967253

?In vivo? administration of valproate decreases t-[35S]butylbicyclophosphorothionate binding in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00967253

Guanosine 3'-5'-Monophosphate in the CSF of Neurological Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00967253

Pharmacological, toxicological and neurochemical effects of delta 2(E)-valproate in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00967253

Comparative pharmacodynamics and brain distribution of E-delta 2-valproate and valproate in rats.

21 January 2018

1 reference

12 December 2020

Effect of inhibitors of GABA transaminase on the synthesis, binding, uptake, and metabolism of GABA

1 reference

12 December 2020

Differential effects of n-dipropylacetate and amino-oxyacetic acid on Gm-aminobutyric acid levels in discrete areas of rat brain

1 reference

12 December 2020

Effects of anticonvulsants on the formation of gamma-hydroxybutyrate from gamma-aminobutyrate in rat brain.

1 reference

12 December 2020

Evidence that a GABAergic mechanism influences the development of DOCA-salt hypertension in the rat

1 reference

12 December 2020

Cyclic nucleotides and nervous system function

1 reference

12 December 2020

Metabolite levels in brain following experimental seizures: the effects of isoniazid and sodium valproate in cerebellar and cerebral cortical layers

1 reference

12 December 2020

Effects of the anticonvulsant sodium valproate on gamma-aminobutyrate and aldehyde metabolism in ox brain

1 reference

12 December 2020

Effect of anticonvulsant drugs on (35S)t-butylbicyclophosphorothionate binding in vitro and ex vivo.

1 reference

12 December 2020

Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock

1 reference

12 December 2020

Pharmacodynamic properties of N-dipropylacetic acid

1 reference

12 December 2020

Changes in Regional Brain Levels of Amino Acid Putative Neurotransmitters After Prolonged Treatment with t he Anticonvulsant Drugs Diphenylhydantoin, Phenobarbitone, Sodium Valproate, Ethosuximide, and Sulthiame in the Rat

1 reference

12 December 2020

Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture.

1 reference

12 December 2020

Valproate enhances GABA turnover in the substantia nigra

1 reference

12 December 2020

Anticonvulsant drugs and the genetically epilepsy-prone rat

1 reference

12 December 2020

Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia

1 reference

12 December 2020

Sodium Valproate Increases Potassium Conductance in Aplysia Neurons

1 reference

12 December 2020

Benzodiazepine cross-tolerance in mice extends to sodium valproate.

1 reference

12 December 2020

Evaluation of epileptic dogs as an animal model of human epilepsy

1 reference

12 December 2020

The effects of sodium valproate on gamma-aminobutyrate metabolism and behaviour in naive and ethanolamine-O-sulphate pretreated rats and mice

1 reference

12 December 2020

Inactivation of beef brain alpha-ketoglutarate dehydrogenase complex by valproic acid and valproic acid metabolites. Possible mechanism of anticonvulsant and toxic actions

1 reference

12 December 2020

Common anticonvulsants inhibit Ca2+ uptake and amino acid neurotransmitter release in vitro.

1 reference

12 December 2020

The action of valproate on spontaneous epileptiform activity in the absence of synaptic transmission and on evoked changes in [Ca2+]o and [K+]o in the hippocampal slice.

1 reference

12 December 2020

Effects of dipropylacetate on the glycine cleavage enzyme system and glycine levels. A possible experimental approach to non-ketotic hyperglycinemia.

1 reference

12 December 2020

Activation of antibody formation by the reticuloendothelial system

1 reference

12 December 2020

[Effects of di-n-propylacetate on audiogenic crises in mice]

1 reference

12 December 2020

The effect of valproic acid on 5-hydroxytryptamine and 5-hydroxyindoleacetic acid concentration in hippocampal dialysates in vivo.

1 reference

12 December 2020

Cerebrospinal fluid gamma-aminobutyric acid levels in children with different types of epilepsy: effect of anticonvulsant treatment

1 reference

12 December 2020

Effect of valproic acid on serotonin metabolism

1 reference

12 December 2020

Effects of anticonvulsant drugs on substantia nigra pars reticulata neurons

1 reference

12 December 2020

gamma-Hydroxybutyrate model of generalized absence seizures: further characterization and comparison with other absence models.

1 reference

12 December 2020

Studies on gamma-aminobutyric acid transport in cobalt experimental epilepsy in the rat

1 reference

12 December 2020

Membrane-disordering potency and anticonvulsant action of valproic acid and other short-chain fatty acids.

1 reference

12 December 2020

Effects of seizures and antiepileptic drugs on benzodiazepine receptors in rat brain

1 reference

12 December 2020

[Neurophysiologic and neurochemical principles of the effect of anticonvulsants]

1 reference

12 December 2020

Effect of convulsant and anticonvulsant agents on level and metabolism of gamma-aminobutyric acid in mouse brain

1 reference

12 December 2020

In vitro studies into the effect of inhibition of rat brain succinic semialdehyde dehydrogenase on GABA synthesis and degradation.

1 reference

12 December 2020

Cerebrospinal fluid monoamine metabolites and cyclic nucleotides in chronic schizophrenic patients with tardive dyskinesia or drug-induced tremor

1 reference

12 December 2020

A comparative study of the pharmacology of inhibitors of GABA-metabolism

1 reference

12 December 2020

Effects of valproate, vigabatrin and aminooxyacetic acid on release of endogenous and exogenous GABA from cultured neurons.

1 reference

12 December 2020

Valproic Acid and Metabolites: Pharmacological and Toxicological Studies

1 reference

12 December 2020

Increase of human plasma GABA by sodium valproate

1 reference

12 December 2020

Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy

1 reference

12 December 2020

Neuronal activity, amino acid concentration and amino acid release in the substantia nigra of the rat after sodium valproate

1 reference

12 December 2020

Evaluation of anticonvulsant drugs in genetic animal models of epilepsy

1 reference

12 December 2020

Valproate suppresses N-methyl-D-aspartate-evoked, transient depolarizations in the rat neocortex in vitro

1 reference

12 December 2020

Lysergic acid diethylamide antagonizes shaking induced in rats by five chemically different compounds

1 reference

12 December 2020

'GABA shift' in vivo: enhancement of benzodiazepine binding in vivo by modulation of endogenous GABA.

1 reference

12 December 2020

Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons

1 reference

12 December 2020

In vivo effects of aminooxyacetic acid and valproic acid on nerve terminal (synaptosomal) GABA levels in discrete brain areas of the rat. Correlation to pharmacological activities.

1 reference

12 December 2020

Valproic acid: metabolite concentrations in plasma and brain, anticonvulsant activity, and effects on GABA metabolism during subacute treatment in mice.

1 reference

12 December 2020

Anticonvulsant potency of common antiepileptic drugs in the gerbil.

1 reference

12 December 2020

Mechanism of action of an anticonvulsant, sodium dipropylacetate

1 reference

12 December 2020

Effects of DI-n-propylacetate, and anticonvulsive compound, on GABA metabolism.

1 reference

12 December 2020

Effect of sodium valproate on motor function regulated by the activation of GABA receptors

1 reference

12 December 2020

[35S]t-butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to gamma-aminobutyric acid-A and ion recognition sites

1 reference

12 December 2020

Antiepileptic drug development: II. Anticonvulsant drug screening

1 reference

12 December 2020

Cellular compartments of GABA in brain and their relationship to anticonvulsant activity

1 reference

12 December 2020

Mechanism of anticonvulsant action of valproate

1 reference

12 December 2020

Valproate: Recent Findings and Perspectives

1 reference

12 December 2020

Di-n-propylacetic acid--profile of anticonvulsant activity in mice

1 reference

12 December 2020

Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes

1 reference

12 December 2020

Valproic Acid: Update on Its Mechanisms of Action

1 reference

12 December 2020

Effect of acute and chronic anticonvulsant administration on endogenous gamma-hydroxybutyrate in rat brain

1 reference

12 December 2020

Effects of sodium valproate on mitochondrial membranes: electron paramagnetic resonance and transmembrane protein movement studies

1 reference

12 December 2020

Valproate enhances GABA-A mediated inhibition of locus coeruleus neurones in vitro

1 reference

12 December 2020

Improved method for isolating synaptosomes from 11 regions of one rat brain: electron microscopic and biochemical characterization and use in the study of drug effects on nerve terminal gamma-aminobutyric acid in vivo.

1 reference

12 December 2020

Human brain, plasma, and cerebrospinal fluid concentration of sodium valproate after 72 hours of therapy

1 reference

12 December 2020

Plasma GABA levels in neurological patients under treatment with valproic acid

1 reference

12 December 2020

Is amygdala kindling in rats a model for drug-resistant partial epilepsy?

1 reference

12 December 2020

The effect of sodium-n-dipropyl acetate on gamma-aminobutyric acid-dependent inhibition in the rat cortex and substantia nigra in relation to its anticonvulsant activity

1 reference

12 December 2020

Monoamine and GABA metabolism and the anticonvulsant action of DI-n-propylacetate and ethanolamine-O-sulphate

1 reference

12 December 2020

The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs

1 reference

12 December 2020

Unusual interactions of benzodiazepine receptor antagonists.

1 reference

12 December 2020

Sodium di-n-propylacetate (valproate) potentiates responses to GABA and muscimol on single central neurones.

1 reference

12 December 2020

Suppression of GABA-induced abstinence behaviour in naive rats by morphine and bicuculline

1 reference

12 December 2020

Valproic acid: brain and plasma levels of the drug and its metabolites, anticonvulsant effects and gamma-aminobutyric acid (GABA) metabolism in the mouse

1 reference

12 December 2020

Valproic acid augments GABA-mediated postsynaptic inhibition in cultured mammalian neurons

1 reference

12 December 2020

Antagonism of N-methyl-D,L-aspartic acid-induced convulsions by antiepileptic drugs and other agents

1 reference

12 December 2020

Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons

1 reference

12 December 2020

Valproic acid increases gamma-aminobutyric acid in CSF of epileptic children.

1 reference

12 December 2020

Valproate induced changes in GABA metabolism at the subcellular level

1 reference

12 December 2020

Changes in brain metabolites induced by convulsants or electroshock: effects of anticonvulsant agents

1 reference

12 December 2020

DMCM: A potent convulsive benzodiazepine receptor ligand

1 reference

12 December 2020

Marked increase in anticonvulsant activity but decrease in wet-dog shake behaviour during short-term treatment of amygdala-kindled rats with valproic acid

1 reference

12 December 2020

Effect of metabolites of valproic acid on the metabolism of GABA in brain and brain nerve endings.

1 reference

12 December 2020

Effect of sodium valproate on hypothalamic neurons in vivo and in vitro.

1 reference

12 December 2020

Sodium valproate enhances responses to GABA receptor activation only at high concentrations

1 reference

12 December 2020

Failure of the antiepileptic drug valproic acid to modify synaptic and non-synaptic responses of CA1 hippocampal pyramidal cells maintained 'in vitro'

1 reference

12 December 2020

Is the anticonvulsant mechanism of valproate linked to its interaction with the cerebral gamma-hydroxybutyrate system?

1 reference

12 December 2020

Di-n-propylacetate and GABA degradation. Preferential inhibition of succinic semialdehyde dehydrogenase and indirect inhibition of GABA-transaminase

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00967253

1 reference

PubMed ID

8097295

Dimensions Publication ID

23 September 2017

0 references

1 reference

PubMed ID

8097295