Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder (Q28241583)

2

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Louise Levine

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Ronald Landbloom

4

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Darryle D Schoepp

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Gary D Tollefson

Metabotropic glutamate II receptor agonists in panic disorder: a double blind clinical trial with LY354740.

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language of work or name

English

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publication date

June 2008

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published in

Neuropsychopharmacology

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volume

33

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issue

7

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page(s)

1603-10

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cites work

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Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist

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Regulation of neurotransmitter release by metabotropic glutamate receptors

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Neurotransmission in the rat amygdala related to fear and anxiety

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Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

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Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results

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Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions.

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Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.

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Open-label trial of riluzole in generalized anxiety disorder

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Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxioly

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7 January 2021

A New Depression Scale Designed to be Sensitive to Change

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An examination of 26,168 Hamilton Depression Rating Scale scores administered via interactive voice response across 17 randomized clinical trials

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The metabotropic glutamate receptors: structure and functions

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The neuroanatomical basis of anxiety

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REPLICATION OF FACTORS OF PSYCHOPATHOLOGY IN INTERVIEW, WARD BEHAVIOR AND SELF-REPORT RATINGS OF HOSPITALIZED DEPRESSIVES

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7 January 2021

Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344.

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LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors

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7 January 2021

LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

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LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats.

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Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

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Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

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Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

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The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam

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7 January 2021

Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats.

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7 January 2021

The hospital anxiety and depression scale

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7 January 2021