Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways (Q37100734)

18 August 2017

Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways (English)

1 reference

non-small-cell lung carcinoma

18 August 2017

1 reference

7

Grace K Dy

1 reference

18 August 2017

6

Alex A Adjei

1 reference

18 August 2017

2

Huanjie Shao

1 reference

18 August 2017

4

Hongbin Chen

1 reference

18 August 2017

Hao Zhang

1

1 reference

18 August 2017

Vita M Golubovskaya

series ordinal

3

1 reference

18 August 2017

William Cance

series ordinal

5

1 reference

18 August 2017

language of work or name

English

0 references

publication date

23 June 2016

1 reference

British Journal of Cancer

18 August 2017

1 reference

18 August 2017

115

1 reference

18 August 2017

2

1 reference

18 August 2017

203-211

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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International

18 August 2017

start time

23 June 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism

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Paxillin confers resistance to tyrosine kinase inhibitors in EGFR-mutant lung cancers via modulating BIM and Mcl-1 protein stability

14 September 2017

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Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers

14 September 2017

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Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines

14 September 2017

1 reference

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Enhanced FGFR signalling predisposes pancreatic cancer to the effect of a potent FGFR inhibitor in preclinical models

14 September 2017

1 reference

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Bcl-2/Bcl-xL inhibition increases the efficacy of MEK inhibition alone and in combination with PI3 kinase inhibition in lung and pancreatic tumor models

14 September 2017

1 reference

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RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas

14 September 2017

1 reference

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Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

14 September 2017

1 reference

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A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

14 September 2017

1 reference

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A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

14 September 2017

1 reference

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Combined effect of ALK and MEK inhibitors in EML4-ALK-positive non-small-cell lung cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo

14 September 2017

1 reference

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Evolving Therapies and FAK Inhibitors for the Treatment of Cancer

14 September 2017

2 references

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14 September 2017

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Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors

21 January 2018

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What are the hallmarks of cancer?

14 September 2017

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Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

14 September 2017

1 reference

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c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges.

14 September 2017

1 reference

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Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.

14 September 2017

1 reference

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A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

The signaling and biological implications of FAK overexpression in cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

Focal adhesion kinase: in command and control of cell motility

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

BCL-2 family members and the mitochondria in apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

The Bcl-2 protein family: arbiters of cell survival

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

TGFbeta-induced EMT requires focal adhesion kinase (FAK) signaling.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism.

29 September 2017

1 reference

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Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

3 September 2018

Bcl-2 family proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947704

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27336608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27336608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Up-regulation of focal adhesion kinase in non-small cell lung cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27336608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/BJC.2016.190

1 reference

Dimensions Publication ID

18 August 2017

0 references

1 reference

18 August 2017

PubMed publication ID

27336608

1 reference