The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria (Q43884355)

27 November 2017

The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria (English)

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27 November 2017

3

Yukiko Gotoh

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27 November 2017

Fuminori Tsuruta

1

1 reference

PubMed ID

11842081

27 November 2017

Norihisa Masuyama

series ordinal

2

1 reference

PubMed ID

11842081

27 November 2017

language of work or name

English

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publication date

12 February 2002

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Journal of Biological Chemistry

27 November 2017

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27 November 2017

277

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27 November 2017

14040-14047

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27 November 2017

16

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The biochemistry of apoptosis

27 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Mitochondria and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Mitochondrial control of cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

BCL-2 family members and the mitochondria in apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Movement of Bax from the cytosol to mitochondria during apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

BAX is required for neuronal death after trophic factor deprivation and during development

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Cellular survival: a play in three Akts

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

The PI3K-PDK1 connection: more than just a road to PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Induction of NF-kappaB by the Akt/PKB kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108975200

CREB is a regulatory target for the protein kinase Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: implicated mechanisms for caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

21 January 2018

Apoptosis in development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108975200

21 January 2018

Identifiers

DOI

10.1074/JBC.M108975200

1 reference

27 November 2017

1 reference

PubMed ID

11842081