Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology. (Q37099349)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27138984%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

title

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology (English)

1 reference

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3 April 2020

0 references

0 references

10

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3 April 2020

8

William Klein

1 reference

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3 April 2020

author name string

Inger Lauritzen

1

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3 April 2020

Raphaëlle Pardossi-Piquard

2

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3 April 2020

Alexandre Bourgeois

3

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3 April 2020

Sophie Pagnotta

4

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3 April 2020

Maria-Grazia Biferi

5

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3 April 2020

Martine Barkats

6

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3 April 2020

Pascale Lacor

7

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3 April 2020

Charlotte Bauer

9

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3 April 2020

publication date

30 April 2016

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3 April 2020

published in

Acta Neuropathologica

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3 April 2020

volume

132

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3 April 2020

page(s)

257-276

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3 April 2020

issue

2

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Creative Commons Attribution 4.0 International

3 April 2020

copyright license

start time

30 April 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4947121/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1007/s00401-016-1577-6

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The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus

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β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.

14 September 2017

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Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide

29 September 2017

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Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies

29 September 2017

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Intracellular pH regulates amyloid precursor protein intracellular domain accumulation.

29 September 2017

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Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease

29 September 2017

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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (E

29 September 2017

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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

27 June 2018

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Influence of Genetic Background on Apathy-Like Behavior in Triple Transgenic AD Mice

27 June 2018

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3 September 2018

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Brain aging and Aβ₁₋₄₂ neurotoxicity converge via deterioration in autophagy-lysosomal system: a conditional Drosophila model linking Alzheimer's neurodegeneration with aging.

3 September 2018

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3 September 2018

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3 September 2018

1 reference

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Monoclonal antibodies that target pathological assemblies of Abeta.

3 September 2018

1 reference

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Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947121

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3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947121

Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947121

Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4947121

Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant.

3 September 2018

1 reference

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Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy.

3 September 2018

1 reference

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Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

3 September 2018

1 reference

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Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

3 September 2018

1 reference

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Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27138984

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00401-016-1577-6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27138984%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27138984%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27138984%20AND%20SRC:MED&resulttype=core&format=json