Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. (Q33667620)

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16 January 2020

title

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition (English)

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16 January 2020

0 references

1 reference

9

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16 January 2020

Stephen D Ginsberg

7

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16 January 2020

author name string

Ying Jiang

1

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16 January 2020

Kerry A Mullaney

2

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16 January 2020

Corrinne M Peterhoff

3

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16 January 2020

Shaoli Che

4

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16 January 2020

Stephen D Schmidt

5

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16 January 2020

Anne Boyer-Boiteau

6

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16 January 2020

Anne M Cataldo

8

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16 January 2020

Ralph A Nixon

10

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16 January 2020

language of work or name

English

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publication date

28 December 2009

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Proceedings of the National Academy of Sciences of the United States of America

16 January 2020

published in

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16 January 2020

volume

107

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16 January 2020

page(s)

1630-1635

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16 January 2020

issue

4

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Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.

16 January 2020

cites work

1 reference

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Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects

14 July 2018

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Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

14 July 2018

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Autophagy, amyloidogenesis and Alzheimer disease

14 July 2018

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APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

14 July 2018

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Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain

14 July 2018

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Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease

14 July 2018

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Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

14 July 2018

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APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

14 July 2018

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Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

14 July 2018

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Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies

14 July 2018

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Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

14 July 2018

1 reference

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Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities

14 July 2018

1 reference

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Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.

14 July 2018

1 reference

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App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

14 July 2018

1 reference

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

14 July 2018

1 reference

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Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments

14 July 2018

1 reference

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A system for stable expression of short interfering RNAs in mammalian cells

14 July 2018

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Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis

14 July 2018

1 reference

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Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity.

14 July 2018

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Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

14 July 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

14 July 2018

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Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease

14 July 2018

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Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

14 July 2018

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Role of the beta-amyloid protein in Alzheimer's disease.

14 July 2018

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Generation of amyloid beta protein from its precursor is sequence specific

14 July 2018

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Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

14 July 2018

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

14 July 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

14 July 2018

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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

14 July 2018

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Influence of the amyloid precursor protein locus on dementia in Down syndrome.

30 October 2018

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BACE1 Suppression by RNA Interference in Primary Cortical Neurons

30 October 2018

1 reference

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Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease.

30 October 2018

1 reference

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Continuing strategies for inhibiting Alzheimer's gamma-secretase.

30 October 2018

1 reference

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30 October 2018

Identifiers

DOI

10.1073/PNAS.0908953107

1 reference

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16 January 2020

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16 January 2020

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