Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability (Q35621293)

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17 January 2020

title

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability (English)

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17 January 2020

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1

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17 January 2020

Patrick S. Ward

2

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17 January 2020

Justin R. Cross

4

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17 January 2020

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Craig B Thompson

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17 January 2020

author name string

Jessica E S Shay

3

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17 January 2020

Joshua J Gruber

5

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17 January 2020

Uma M Sachdeva

6

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17 January 2020

Jesse M Platt

7

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17 January 2020

Raymond G DeMatteo

8

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17 January 2020

M Celeste Simon

9

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17 January 2020

language of work or name

English

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publication date

21 November 2011

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Proceedings of the National Academy of Sciences of the United States of America

17 January 2020

published in

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17 January 2020

volume

108

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17 January 2020

page(s)

19611-19616

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17 January 2020

issue

49

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Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production

17 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival

27 July 2018

1 reference

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Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

Hypoxia. 2. Hypoxia regulates cellular metabolism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

27 July 2018

1 reference

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

27 July 2018

1 reference

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

27 July 2018

1 reference

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

27 July 2018

1 reference

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The impact of O2 availability on human cancer

27 July 2018

1 reference

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

ATP citrate lyase inhibition can suppress tumor cell growth

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

Investigations by mass isotopomer analysis of the formation of D-2-hydroxyglutarate by cultured lymphoblasts from two patients with D-2-hydroxyglutaric aciduria

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

Quiescent fibroblasts exhibit high metabolic activity.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

ATP-citrate lyase links cellular metabolism to histone acetylation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

Understanding the Warburg effect: the metabolic requirements of cell proliferation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241793

Glutamine metabolism in AS-30D hepatoma cells. Evidence for its conversion into lipids via reductive carboxylation

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22106302

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Localization and kinetics of reduced pyridine nucleotide in living cells by microfluorometry

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22106302

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mitochondrial NADPH, transhydrogenase and disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22106302

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1117773108

1 reference

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17 January 2020

0 references

1 reference

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17 January 2020

1 reference