Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. (Q36945031)

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15 January 2020

title

Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice (English)

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Nicolas Degauque

9

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Towia A Libermann

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Jeffrey S Flier

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author name string

Maria Koulmanda

1

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15 January 2020

Lauren Hoffman

3

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Zhigang Fan

4

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Andi Qipo

5

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15 January 2020

Hang Shi

6

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15 January 2020

Susan Bonner-Weir

7

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Prabhakar Putheti

8

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Hugh Auchincloss

11

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Terry B Strom

13

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language of work or name

English

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publication date

13 October 2008

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Proceedings of the National Academy of Sciences of the United States of America

15 January 2020

published in

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15 January 2020

volume

105

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page(s)

16242-16247

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issue

42

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alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice

15 January 2020

cites work

1 reference

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Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts

29 September 2017

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Alpha1-antitrypsin protects beta-cells from apoptosis

29 September 2017

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Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice

29 September 2017

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Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes

29 September 2017

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

29 September 2017

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Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

29 September 2017

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A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema

29 September 2017

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

29 September 2017

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A comprehensive review of interventions in the NOD mouse and implications for translation

29 September 2017

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Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice

29 September 2017

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Alpha1-antitrypsin deficiency

29 September 2017

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Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes

29 September 2017

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Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts

29 September 2017

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CD103 mRNA levels in urinary cells predict acute rejection of renal allografts.

29 September 2017

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Alpha1-antitrypsin: not just an antiprotease: extending the half-life of a natural anti-inflammatory molecule by conjugation with polyethylene glycol

29 September 2017

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Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

29 September 2017

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A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

29 September 2017

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29 September 2017

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Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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4 September 2018

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Protective effects of alpha 1-antitrypsin on acute lung injury in rabbits induced by endotoxin.

4 September 2018

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TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

4 September 2018

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Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects

4 September 2018

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4 September 2018

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4 September 2018

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The effect of alpha 1 antitrypsin on the proliferative response of human peripheral blood lymphocytes

4 September 2018

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12 December 2020

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Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

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Gene signatures of progression and metastasis in renal cell cancer

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Identifiers

DOI

10.1073/PNAS.0808031105

1 reference

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15 January 2020

0 references

1 reference

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15 January 2020

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