TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes (Q47667692)

4 February 2018

title

TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes (English)

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Jeffrey A Bluestone

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author name string

Mériam Belghith

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Samia Barriot

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Jérôme Mégret

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Jean-François Bach

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Lucienne Chatenoud

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publication date

24 August 2003

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language of work or name

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volume

9

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issue

9

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page(s)

1202-1208

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Tolerance to islet autoantigens in type 1 diabetes

cites work

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7 January 2021

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

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7 January 2021

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7 January 2021

Corticosteroid inhibition of the OKT3-induced cytokine-related syndrome--dosage and kinetics prerequisites

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7 January 2021

Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant recipients

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7 January 2021

Anti-CD3 F(ab')2 fragments are immunosuppressive in vivo without evoking either the strong humoral response or morbidity associated with whole mAb

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7 January 2021

Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala-Ala) in the treatment of acute renal allograft rejection

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7 January 2021

PHASE I STUDY OF AN ENGINEERED AGLYCOSYLATED HUMANIZED CD3 ANTIBODY IN RENAL TRANSPLANT REJECTION1

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7 January 2021

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

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7 January 2021

Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody

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7 January 2021

Antigenic modulation - a major mechanism of antibody action

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7 January 2021

The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7

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7 January 2021

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

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7 January 2021

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

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7 January 2021

CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations

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7 January 2021

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice

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7 January 2021

Lack of L-selectin expression by cells transferring diabetes in NOD mice: insights into the mechanisms involved in diabetes prevention by Mel-14 antibody treatment.

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7 January 2021

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

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7 January 2021

Suppressor T cells – they’re back and critical for regulation of autoimmunity!

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7 January 2021

CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes

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Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

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7 January 2021

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

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CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

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7 January 2021

CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness

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7 January 2021

Interleukin-4 Deficiency Does Not Exacerbate Disease in NOD Mice

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7 January 2021

Transforming growth factor beta (TGF-beta)-dependent inhibition of T helper cell 2 (Th2)-induced autoimmunity by self-major histocompatibility complex (MHC) class II-specific, regulatory CD4(+) T cell lines.

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7 January 2021

Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice.

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7 January 2021

Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytes

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7 January 2021

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

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7 January 2021

Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells

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Anti-suppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice

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A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

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Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells.

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7 January 2021

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

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Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance

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Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes

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CTLA-4 can function as a negative regulator of T cell activation

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7 January 2021

Identifiers

DOI

10.1038/NM924

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4 February 2018

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4 February 2018