Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat. (Q36937206)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812510%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat (English)

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14 January 2020

1 reference

1 reference

2

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14 January 2020

author name string

Won-Seok Choi

series ordinal

1

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14 January 2020

Richard D Palmiter

series ordinal

3

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14 January 2020

Zhengui Xia

series ordinal

4

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14 January 2020

language of work or name

English

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publication date

23 September 2008

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14 January 2020

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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14 January 2020

volume

105

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14 January 2020

page(s)

15136-15141

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14 January 2020

issue

39

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Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy

14 January 2020

cites work

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Paraquat neurotoxicity is distinct from that of MPTP and rotenone.

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29 September 2017

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29 September 2017

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Clinical heterogeneity in patients with mutations in the NDUFS4 gene of mitochondrial complex I

29 September 2017

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Molecular Pathways of Neurodegeneration in Parkinson's Disease

29 September 2017

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D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease

29 September 2017

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29 September 2017

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Pathological mutations of the human NDUFS4 gene of the 18-kDa (AQDQ) subunit of complex I affect the expression of the protein and the assembly and function of the complex

29 September 2017

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Mutations in human nuclear genes encoding for subunits of mitochondrial respiratory complex I: the NDUFS4 gene

29 September 2017

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A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome

29 September 2017

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The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease.

29 September 2017

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

29 September 2017

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29 September 2017

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Mechanisms of toxicity, clinical features, and management of diquat poisoning: a review

29 September 2017

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A mechanism of paraquat toxicity involving nitric oxide synthase

29 September 2017

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Etiology and pathogenesis of Parkinson's disease

29 September 2017

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Demonstration of a new pathogenic mutation in human complex I deficiency: a 5-bp duplication in the nuclear gene encoding the 18-kD (AQDQ) subunit

29 September 2017

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

29 September 2017

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Decreased susceptibility to oxidative stress underlies the resistance of specific dopaminergic cell populations to paraquat-induced degeneration

29 September 2017

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An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.

27 June 2018

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Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss.

27 June 2018

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Glucose transport in primary cultured neurons

27 June 2018

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Partial mitochondrial complex I inhibition induces oxidative damage and perturbs glutamate transport in primary retinal cultures. Relevance to Leber Hereditary Optic Neuropathy (LHON).

27 June 2018

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In vivo complementation of complex I by the yeast Ndi1 enzyme. Possible application for treatment of Parkinson disease

4 September 2018

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The parkinsonism producing neurotoxin MPP+ affects microtubule dynamics by acting as a destabilising factor

4 September 2018

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Selective vulnerability of dopaminergic neurons to microtubule depolymerization

4 September 2018

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Role of oxidative stress in paraquat-induced dopaminergic cell degeneration.

4 September 2018

1 reference

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Iron dysregulation and Parkinson's disease.

4 September 2018

1 reference

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Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567505

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567505

Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567505

Acetyl-L-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567505

Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats

4 September 2018

1 reference

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α-Synuclein Overexpression Protects against Paraquat-Induced Neurodegeneration

4 September 2018

1 reference

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Effects of L-dopa and other amino acids against paraquat-induced nigrostriatal degeneration

4 September 2018

1 reference

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Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567505

Pergolide protects dopaminergic neurons in primary culture under stress conditions

4 September 2018

1 reference

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Paraquat- and diquat-induced oxygen radical generation and lipid peroxidation in rat brain microsomes

4 September 2018

1 reference

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The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein

4 September 2018

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Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease

4 September 2018

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Effects of paraquat on mitochondrial electron transport system and catecholamine contents in rat brain.

4 September 2018

1 reference

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Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide

4 September 2018

1 reference

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Combined enzymatic complex I and III deficiency associated with mutations in the nuclear encoded NDUFS4 gene

4 September 2018

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12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

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12 December 2020

Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

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12 December 2020

Abnormalities of the electron transport chain in idiopathic Parkinson's disease

1 reference

12 December 2020

Mechanism of cytotoxicity of paraquat. III. The effects of acute paraquat exposure on the electron transport system in rat mitochondria

1 reference

12 December 2020

Mitochondrial NADH-quinone oxidoreductase of the outer membrane is responsible for paraquat cytotoxicity in rat livers

1 reference

12 December 2020

Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways

1 reference

12 December 2020

Mode of inhibitory action of Deltalac-acetogenins, a new class of inhibitors of bovine heart mitochondrial complex I

1 reference

12 December 2020

p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65

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12 December 2020

The use of the BD oxygen biosensor system to assess isolated human islets of langerhans: oxygen consumption as a potential measure of islet potency

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0807581105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812510%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812510%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference