Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis (Q36895504)

16 August 2017

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title

Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis (English)

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16 August 2017

Ahmed M Elsharkawy

1

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PubMed ID

17661407

16 August 2017

Derek A Mann

series ordinal

2

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PubMed ID

17661407

16 August 2017

language of work or name

English

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publication date

1 August 2007

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16 August 2017

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16 August 2017

46

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16 August 2017

2

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16 August 2017

590-597

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Hepatocellular carcinoma: epidemiology, risk factors, and screening

16 August 2017

1 reference

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Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

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Introduction to NF-kappaB: players, pathways, perspectives

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Integrating cell-signalling pathways with NF-kappaB and IKK function

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The IKK NF-kappa B system: a treasure trove for drug development

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Possible new role for NF-kappaB in the resolution of inflammation.

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NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages

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Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury

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Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients

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The liver as an immunological organ

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Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins.

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Reversal effect of thalidomide on established hepatic cirrhosis in rats via inhibition of nuclear factor-kappaB/inhibitor of nuclear factor-kappaB pathway.

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Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy

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NF-kappaB is activated in cholestasis and functions to reduce liver injury

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

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IKK-beta links inflammation to obesity-induced insulin resistance

1 reference

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Toll-like receptor signaling in the liver

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Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity

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Alcohol and oxidative liver injury

1 reference

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Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus

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Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB.

1 reference

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Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance

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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

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NF-kappaB functions as a tumour promoter in inflammation-associated cancer

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The Hallmarks of Cancer

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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

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Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.

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Evaluation of nuclear factor-kappaB, urokinase-type plasminogen activator, and HBx and their clinicopathological significance in hepatocellular carcinoma

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Activation of nuclear factor kappaB in hepatitis C virus infection: implications for pathogenesis and hepatocarcinogenesis

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Nuclear factor-kappaB and liver carcinogenesis

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High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation

1 reference

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IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

1 reference

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Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury

1 reference

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Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury

1 reference

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Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro.

1 reference

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Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

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The bone marrow functionally contributes to liver fibrosis.

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Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells

1 reference

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Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair

1 reference

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Matrix metalloproteinase-9 is an important factor in hepatic regeneration after partial hepatectomy in mice

1 reference

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Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR

1 reference

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Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1

1 reference

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Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis.

1 reference

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Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

1 reference

7 January 2021

Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats

1 reference

7 January 2021

CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells

1 reference

7 January 2021

IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

1 reference

7 January 2021

Identifiers

DOI

10.1002/HEP.21802

1 reference

16 August 2017

1 reference

PubMed ID

17661407