Mechanisms of disease: genetic predictors of response to treatment in brain tumors (Q36834030)

16 August 2017

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title

Mechanisms of disease: genetic predictors of response to treatment in brain tumors (English)

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16 August 2017

V Peter Collins

1

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16 August 2017

1 June 2007

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Nature Clinical Practice Oncology

16 August 2017

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16 August 2017

4

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16 August 2017

6

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16 August 2017

362-374

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Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas

16 August 2017

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https://api.crossref.org/works/10.1038%2FNCPONC0820

Promoter hypermethylation of the RB1 gene in glioblastomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

The complexity of the 7p12 amplicon in human astrocytic gliomas: detailed mapping of 246 tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

Oligodendroglioma: toward molecular definitions in diagnostic neuro-oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

The second generation of BCR-ABL tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Epidemiology and molecular pathology of glioma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Malignant oligodendroglioma arising after radiation therapy for lymphoma.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Investigation of human brain tumors for the presence of polyomavirus genome sequences by two independent laboratories

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Genetic and environmental factors in the etiology of human brain tumors

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https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Genetic epidemiology of glioma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

P-Glycoprotein, a gatekeeper in the blood-brain barrier

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https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Optimal role of temozolomide in the treatment of malignant gliomas.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Clinicopathologic study of 85 similarly treated patients with anaplastic astrocytic tumors. An analysis of DNA content (ploidy), cellular proliferation, and p53 expression.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Molecular markers of prognosis in astrocytic tumors.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Mitotic recombination of chromosome 17 in astrocytomas

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Comparative genomic hybridization in glioma: a meta-analysis of 509 cases.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomas.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Genetic pathways to glioblastoma: a population-based study

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https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

The RB and p53 pathways in cancer

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https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Molecular pathogenesis of astrocytic tumours

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https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Gene amplification in human gliomas

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Distinct transcription profiles of primary and secondary glioblastoma subgroups.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Successful chemotherapy for recurrent malignant oligodendroglioma.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Identification of der(1;19)(q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment [...]

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Two types of chromosome 1p losses with opposite significance in gliomas.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Ras, PI(3)K and mTOR signalling controls tumour cell growth

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https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

The genetic and molecular pathogenesis of NF1 and NF2.

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https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Familial Adenomatous Polyposis

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https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

The molecular basis of Turcot's syndrome

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https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Critical issues in the identification and management of patients with hereditary non-polyposis colorectal cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

The neurobiology of tuberous sclerosis complex

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Dysregulation of the TSC-mTOR pathway in human disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

The biology and clinical relevance of the PTEN tumor suppressor pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

The genetics of hereditary melanoma and nevi. 1998 update

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https://api.crossref.org/works/10.1038%2FNCPONC0820

7 January 2021

Identifiers

DOI

10.1038/NCPONC0820

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16 August 2017

1 reference

PubMed ID

17534392