P-Glycoprotein, a gatekeeper in the blood-brain barrier (Q33904245)

29 July 2017

P-Glycoprotein, a gatekeeper in the blood-brain barrier (English)

1 reference

29 July 2017

1 reference

Schinkel AH

1

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PubMed ID

10837715

29 July 2017

language of work or name

English

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publication date

1 April 1999

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Advanced Drug Delivery Reviews

29 July 2017

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29 July 2017

36

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29 July 2017

179-194

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29 July 2017

2-3

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The biochemistry of P-glycoprotein-mediated multidrug resistance

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Biochemistry of multidrug resistance mediated by the multidrug transporter

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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

A mechanism for P-glycoprotein action in multidrug resistance: are we there yet?

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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Genetic dissection of the function of mammalian P-glycoproteins

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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Is the multidrug transporter a flippase?

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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Clinical studies with modulators of multidrug resistance.

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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities

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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

The Blood-Brain Barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Recent advances in blood-brain barrier transport

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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

The blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

The blood-brain barrier. Transport across the cerebral endothelium

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Ultrastructural localization of P-glycoprotein on capillary endothelial cells in human gliomas

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Cellular localization of P-glycoprotein in brain versus gonadal capillaries

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Interaction of drugs with P-glycoprotein in brain capillaries

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Expression of the multiple drug resistance gene (mdr-1) and epitope masking in chronic lymphatic leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Some monoclonal antibody reagents (C219 and JSB-1) to P-glycoprotein contain antibodies to blood group A carbohydrate determinants: a problem of quality control for immunohistochemical analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

MDR1 gene expression in brain of patients with medically intractable epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated protein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Comparisons of P-glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Isolation and culture of human brain microvessel endothelial cells for the study of blood-brain barrier properties in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

HIV-1 protease inhibitors and the MDR1 multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Effect of the p-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Dose-dependent brain penetration of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin, in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Decreased biotolerability for ivermectin and cyclosporin A in mice exposed to potent P-glycoprotein inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

A method to determine the ability of drugs to diffuse through the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

The functional role of P-glycoprotein in the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4

7 January 2021

10.1016/S0169-409X(98)00085-4

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10837715