Genetic association meets RNA interference: large-scale genomic screens for causation and mechanism of complex diseases (Q36804396)

16 August 2017

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title

Genetic association meets RNA interference: large-scale genomic screens for causation and mechanism of complex diseases (English)

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16 August 2017

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Mitchell Martin

1

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PubMed ID

17465709

16 August 2017

John F Reidhaar-Olson

series ordinal

2

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PubMed ID

17465709

16 August 2017

Cristina M Rondinone

series ordinal

3

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16 August 2017

1 May 2007

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16 August 2017

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16 August 2017

8

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16 August 2017

5

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16 August 2017

455-464

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Disease-specific target selection: a critical first step down the right road

16 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Glucokinase (GCK) mutations in hyper- and hypoglycemia: Maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Human monogenic disorders - a source of novel drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Genetic factors in type 2 diabetes: the end of the beginning?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

The lipoprotein lipase (Asn291-->Ser) mutation is associated with elevated lipid levels in families with familial combined hyperlipidaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Genetic analysis of autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Highly parallel genomic assays

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Whole-genome patterns of common DNA variation in three human populations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Complement factor H polymorphism in age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Complement factor H variant increases the risk of age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Complement factor H polymorphism and age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

The International HapMap Project

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Using haplotype blocks to map human complex trait loci

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Genome-wide association studies for common diseases and complex traits

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Reverse engineering gene networks to identify key drivers of complex disease phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Genome-wide strategies for detecting multiple loci that influence complex diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Rational siRNA design for RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Simultaneous amplification and detection of specific DNA sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Building mammalian signalling pathways with RNAi screens

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

A resource for large-scale RNA-interference-based screens in mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

High-throughput RNAi screening in cultured cells: a user's guide.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

RNAi microarray analysis in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Progress towards in vivo use of siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Cationic lipids enhance siRNA-mediated interferon response in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

RNA interference in adult mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Inhibition of hepatitis B virus in mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

RNAi-mediated gene silencing in non-human primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Overcoming diabetes-induced hyperglycemia through inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP) with RNAi.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Defective viral vectors as agents for gene transfer in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Improving the transfection efficiency of post-mitotic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Transfection of "naked" siRNA results in endosomal uptake and metabolic impairment in cultured neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Regulated, electroporation-mediated delivery of pro-opiomelanocortin gene suppresses chronic constriction injury-induced neuropathic pain in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Successful incorporation of short-interfering RNA into islet cells by in situ perfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Gene silencing in the endocrine pancreas mediated by short-interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Sequence-specific gene silencing in murine muscle induced by electroporation-mediated transfer of short interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Liposomes modified with cyclic RGD peptide for tumor targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Modulation of angiogenesis with siRNA inhibitors for novel therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

The value of improving the productivity of the drug development process: faster times and better decisions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.5.455

Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

21 January 2018

1 reference

12 January 2024

https://opencitations.net/index/api/v1/citations/10.1172/JCI23187

Identifiers

DOI

10.2217/14622416.8.5.455

1 reference

16 August 2017

1 reference

PubMed ID

17465709