Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction (Q36741881)

16 August 2017

1 reference

title

Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction (English)

1 reference

16 August 2017

0 references

M J Christie

1

1 reference

PMCID

2442443

16 August 2017

language of work or name

English

0 references

publication date

14 April 2008

1 reference

British Journal of Pharmacology

16 August 2017

1 reference

16 August 2017

154

1 reference

16 August 2017

384-396

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16 August 2017

2

1 reference

Synaptic plasticity and addiction

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Dynorphin and the pathophysiology of drug addiction

29 September 2017

1 reference

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Phosphorylation of Galphas influences its association with the micro-opioid receptor and is modulated by long-term morphine exposure

29 September 2017

1 reference

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Opioid dependence and addiction during opioid treatment of chronic pain

29 September 2017

1 reference

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Sensing and expressing homeostatic synaptic plasticity.

29 September 2017

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Regulatory mechanisms of AMPA receptors in synaptic plasticity

29 September 2017

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29 September 2017

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IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates.

29 September 2017

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Activation in extended amygdala corresponds to altered hedonic processing during protracted morphine withdrawal

29 September 2017

1 reference

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An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization

29 September 2017

1 reference

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Role of ERK in cocaine addiction.

29 September 2017

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NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory

29 September 2017

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The role of opioid receptor phosphorylation and trafficking in adaptations to persistent opioid treatment

29 September 2017

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Endogenous orphanin FQ/nociceptin is involved in the development of morphine tolerance

29 September 2017

1 reference

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Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location

29 September 2017

1 reference

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Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex

29 September 2017

1 reference

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Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.

29 September 2017

1 reference

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Relapse to alcohol and drug use among individuals diagnosed with co-occurring mental health and substance use disorders: a review

29 September 2017

1 reference

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Addiction and its brain science

29 September 2017

1 reference

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Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

29 September 2017

1 reference

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Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications

29 September 2017

1 reference

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Novel pharmacotherapeutic targets for the management of drug addiction

29 September 2017

1 reference

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Glia: novel counter-regulators of opioid analgesia

29 September 2017

1 reference

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29 September 2017

The many faces of CREB

1 reference

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Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Role of NK-1 neurotransmission in opioid-induced hyperalgesia

29 September 2017

1 reference

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A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

29 September 2017

1 reference

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Sensitization of adenylate cyclase by Galpha i/o-coupled receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Age-dependent opioid escalation in chronic pain patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities.

29 September 2017

1 reference

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Opioids: cellular mechanisms of tolerance and physical dependence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

AKAP signalling complexes: focal points in space and time

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Mu-opioid receptor desensitization: is morphine different?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Receptor endocytosis counteracts the development of opioid tolerance

29 September 2017

1 reference

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Brain substrates for increased drug seeking during protracted withdrawal

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

29 September 2017

1 reference

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Chronic morphine treatment reduces recovery from opioid desensitization

29 September 2017

1 reference

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Desensitization of G protein-coupled receptors and neuronal functions

29 September 2017

1 reference

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Addition of a second opioid may improve opioid response in cancer pain: preliminary data

29 September 2017

1 reference

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Mitogen-activated protein kinases in synaptic plasticity and memory.

29 September 2017

1 reference

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29 September 2017

1 reference

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Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

29 September 2017

1 reference

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ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system

29 September 2017

1 reference

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Desensitization of mu-opioid receptor-evoked potassium currents: initiation at the receptor, expression at the effector

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization

29 September 2017

1 reference

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Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons

29 September 2017

1 reference

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Cellular and synaptic adaptations mediating opioid dependence.

29 September 2017

1 reference

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Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence.

29 September 2017

1 reference

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Molecular mechanisms and regulation of opioid receptor signaling

29 September 2017

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Role for GDNF in biochemical and behavioral adaptations to drugs of abuse.

29 September 2017

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Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

29 September 2017

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Opioid receptor signalling mechanisms.

29 September 2017

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Morphine-activated opioid receptors elude desensitization by beta-arrestin

29 September 2017

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Carboxyl-terminal splicing of the rat mu opioid receptor modulates agonist-mediated internalization and receptor resensitization.

29 September 2017

1 reference

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mu-Opposing actions of the kappa-opioid receptor

29 September 2017

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The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.

29 September 2017

1 reference

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Morphine activates opioid receptors without causing their rapid internalization

29 September 2017

1 reference

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Locus-specific rescue of GluRepsilon1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence.

29 September 2017

1 reference

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Enhanced opioid efficacy in opioid dependence is caused by an altered signal transduction pathway.

28 June 2018

1 reference

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Increased opioid inhibition of GABA release in nucleus accumbens during morphine withdrawal.

28 June 2018

1 reference

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Where is the locus in opioid withdrawal?

28 June 2018

1 reference

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Local opioid withdrawal in rat single periaqueductal gray neurons in vitro.

28 June 2018

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A common mechanism mediates long-term changes in synaptic transmission after chronic cocaine and morphine.

28 June 2018

1 reference

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Cellular mechanisms of opioid tolerance: studies in single brain neurons

28 June 2018

1 reference

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Cholera toxin-A subunit blocks opioid excitatory effects on sensory neuron action potentials indicating mediation by Gs-linked opioid receptors

28 June 2018

1 reference

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Opioids excite dopamine neurons by hyperpolarization of local interneurons.

28 June 2018

1 reference

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Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area.

28 June 2018

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Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons.

5 September 2018

1 reference

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Opioids block long-term potentiation of inhibitory synapses.

5 September 2018

1 reference

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Should we be reluctant to prescribe opioids for chronic non-malignant pain?

5 September 2018

1 reference

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Prescription drug abuse rises globally

5 September 2018

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How important is protein kinase C in mu-opioid receptor desensitization and morphine tolerance?

5 September 2018

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Behavioral and electrophysiological evidence for opioid tolerance in adolescent rats

5 September 2018

1 reference

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Contingent and non-contingent effects of heroin on mu-opioid receptor-containing ventral tegmental area GABA neurons

5 September 2018

1 reference

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Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors.

5 September 2018

1 reference

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Separation of mu-opioid receptor desensitization and internalization: endogenous receptors in primary neuronal cultures.

5 September 2018

1 reference

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Adenylyl cyclase type II activity is regulated by two different mechanisms: implications for acute and chronic opioid exposure

5 September 2018

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Contribution of brainstem GABA(A) synaptic transmission to morphine analgesic tolerance.

5 September 2018

1 reference

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CREB modulates excitability of nucleus accumbens neurons

5 September 2018

1 reference

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An essential role for DeltaFosB in the nucleus accumbens in morphine action.

5 September 2018

1 reference

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Enhanced Fos expression in glutamic acid decarboxylase immunoreactive neurons of the mouse periaqueductal grey during opioid withdrawal

5 September 2018

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Plasticity of reward neurocircuitry and the 'dark side' of drug addiction

5 September 2018

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Enhanced c-Fos in periaqueductal grey GABAergic neurons during opioid withdrawal

5 September 2018

1 reference

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Morphine-Induced mu-opioid receptor desensitization

5 September 2018

1 reference

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Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment.

5 September 2018

1 reference

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Protein kinase C activation enhances morphine-induced rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons

5 September 2018

1 reference

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Neuronal protein kinase C gamma-dependent proliferation and hypertrophy of spinal cord astrocytes following repeated in vivo administration of morphine

5 September 2018

1 reference

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Mu-opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine.

5 September 2018

1 reference

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Brain region-specific mechanisms for acute morphine-induced mitogen-activated protein kinase modulation and distinct patterns of activation during analgesic tolerance and locomotor sensitization.

5 September 2018

1 reference

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Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro

5 September 2018

1 reference

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Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons.

5 September 2018

1 reference

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Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Regulation of RGS proteins by chronic morphine in rat locus coeruleus

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Rostral ventromedial medulla neurons that project to the spinal cord express multiple opioid receptor phenotypes.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Opioid agonists differentially regulate mu-opioid receptors and trafficking proteins in vivo

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

mu-Opioid receptor downregulation contributes to opioid tolerance in vivo

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Local opiate withdrawal in locus coeruleus neurons in vitro

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Evaluation of rat ultrasonic vocalizations as predictors of the conditioned aversive effects of drugs.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

The involvement of glial cells in the development of morphine tolerance

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Chronic heroin self-administration desensitizes mu opioid receptor-activated G-proteins in specific regions of rat brain.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Opioid receptor endocytosis and activation of MAP kinase pathway

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

A mitogen-activated protein kinase pathway is required for mu-opioid receptor desensitization

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442443

Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18414400

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sensitization to repeated morphine injection in the rat: possible involvement of A10 dopamine neurons

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18414400

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Increased probability of GABA release during withdrawal from morphine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18414400

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/BJP.2008.100

1 reference

16 August 2017

1 reference

16 August 2017

1 reference

PMCID

2442443