Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors (Q44340828)

2 December 2017

Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors (English)

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2 December 2017

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Stephanie L. Borgland

series ordinal

1

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2 December 2017

2

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2 December 2017

MacDonald J Christie

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PubMed ID

12642578

2 December 2017

language of work or name

English

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publication date

17 March 2003

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Journal of Biological Chemistry

2 December 2017

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2 December 2017

278

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2 December 2017

18776-18784

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2 December 2017

21

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Opioids in pain management

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Characterization of acute homologous desensitization of mu-opioid receptor-induced currents in locus coeruleus neurones.

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Morphine activates opioid receptors without causing their rapid internalization

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Agonist-selective endocytosis of mu opioid receptor by neurons in vivo

21 January 2018

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Differential mu opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters.

21 January 2018

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Mu opioid receptor phosphorylation, desensitization, and ligand efficacy

21 January 2018

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Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness

21 January 2018

1 reference

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Morphine-activated opioid receptors elude desensitization by beta-arrestin

21 January 2018

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Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins

21 January 2018

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Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

21 January 2018

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Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain.

21 January 2018

1 reference

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Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

21 January 2018

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Molecular components of tolerance to opiates in single hippocampal neurons

21 January 2018

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The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation

21 January 2018

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Methadone-induced desensitization of the delta-opioid receptor is mediated by uncoupling of receptor from G protein

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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

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Quantitation of neurokinin 1 receptor internalization and recycling in guinea-pig myenteric neurons.

21 January 2018

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Improved models for pharmacological null experiments: calculation of drug efficacy at recombinant D1A dopamine receptors stably expressed in clonal cell lines

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Nonlinear analysis of partial dopamine agonist effects on cAMP in C6 glioma cells

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Non-opioid dynorphin binding site on secretory vesicles of a pituitary-derived cell line

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Tonic inhibition and rebound facilitation of a neuronal calcium channel by a GTP-binding protein

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Differential regulation of the cloned kappa and mu opioid receptors

21 January 2018

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Determinants of the G protein-dependent opioid modulation of neuronal calcium channels

21 January 2018

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Modulation of Ca2+ channels by G-protein beta gamma subunits

21 January 2018

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Voltage-dependent modulation of N-type calcium channels by G-protein beta gamma subunits

21 January 2018

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Efficacy in drug receptor theory: outdated concept or under-valued tool?

21 January 2018

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Drug efficacy at G protein-coupled receptors

21 January 2018

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Differences in efficacies between morphine and methadone demonstrated in the guinea pig ileum: a possible explanation for previous observations on incomplete opioid cross-tolerance

21 January 2018

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Desensitization of mu-opioid receptor-evoked potassium currents: initiation at the receptor, expression at the effector

21 January 2018

1 reference

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Noradrenaline- and Enkephalin-Induced Inhibition of Voltage-Sensitive Calcium Currents in NG108-15 Hybrid Cells.

21 January 2018

1 reference

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Desensitization and resensitization of delta-opioid receptor-mediated Ca2+ channel inhibition in NG108-15 cells

21 January 2018

1 reference

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Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro

21 January 2018

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Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes

21 January 2018

1 reference

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Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I

21 January 2018

1 reference

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Mechanism of quenching of phototransduction. Binding competition between arrestin and transducin for phosphorhodopsin.

21 January 2018

1 reference

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mu and delta-opioid receptor agonists induce mitogen-activated protein kinase (MAPK) activation in the absence of receptor internalization

21 January 2018

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Somatostatin receptor desensitization in NG108-15 cells. A consequence of receptor sequestration.

21 January 2018

1 reference

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C-terminal splice variants of the mouse mu-opioid receptor differ in morphine-induced internalization and receptor resensitization

21 January 2018

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Differential in vivo internalization of MOR-1 and MOR-1C by morphine

21 January 2018

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Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization.

21 January 2018

1 reference

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ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M300525200

1 reference

2 December 2017

1 reference

PubMed ID

12642578