Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response (Q74359929)

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10 November 2019

title

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response (English)

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10 November 2019

author name string

Yanjun Ma

1

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10 November 2019

Joseph W Brewer

2

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10 November 2019

J Alan Diehl

3

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10 November 2019

Linda M Hendershot

4

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10 November 2019

publication date

1 May 2002

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Journal of Molecular Biology

10 November 2019

number of pages

15

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inferred from page(s)

published in

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10 November 2019

volume

318

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10 November 2019

page(s)

1351-1365

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10 November 2019

issue

5

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CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

10 November 2019

cites work

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Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element

7 January 2021

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Identification of novel stress-induced genes downstream of chop

7 January 2021

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Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10

7 January 2021

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

7 January 2021

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CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

7 January 2021

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Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

7 January 2021

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Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

7 January 2021

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A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus

7 January 2021

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The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response

7 January 2021

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Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response

7 January 2021

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Unconventional splicing of HAC1/ERN4 mRNA required for the unfolded protein response. Sequence-specific and non-sequential cleavage of the splice sites

7 January 2021

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tRNA ligase is required for regulated mRNA splicing in the unfolded protein response

7 January 2021

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Mammalian stress response: induction of the glucose-regulated protein family

7 January 2021

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

7 January 2021

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Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression

7 January 2021

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PERK mediates cell-cycle exit during the mammalian unfolded protein response

7 January 2021

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Regulation of the C/EBP-related gene gadd153 by glucose deprivation

7 January 2021

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Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

7 January 2021

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

7 January 2021

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A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

7 January 2021

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Cloning of mammalian Ire1 reveals diversity in the ER stress responses

7 January 2021

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A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

7 January 2021

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Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

7 January 2021

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

7 January 2021

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

7 January 2021

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ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

7 January 2021

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Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

7 January 2021

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The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex

7 January 2021

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CHOP gene expression in response to endoplasmic-reticular stress requires NFY interaction with different domains of a conserved DNA-binding element

7 January 2021

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

7 January 2021

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

7 January 2021

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Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6.

7 January 2021

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Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

7 January 2021

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Amino Acid Limitation Induces Expression ofCHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

7 January 2021

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Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress

7 January 2021

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Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response

7 January 2021

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Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response.

7 January 2021

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Amino acids control mammalian gene transcription: activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter

7 January 2021

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

7 January 2021

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Inhibition of translational initiation by activators of the glucose-regulated stress protein and heat shock protein stress response systems. Role of the interferon-inducible double-stranded RNA-activated eukaryotic initiation factor 2alpha kinase

7 January 2021

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7 January 2021

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Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response

7 January 2021

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The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx

7 January 2021

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ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase

7 January 2021

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Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha

7 January 2021

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C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival

7 January 2021

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The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)

7 January 2021

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The dynamic role of GRP78/BiP in the coordination of mRNA translation with protein processing

7 January 2021

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Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun

7 January 2021

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In vivo expression of mammalian BiP ATPase mutants causes disruption of the endoplasmic reticulum

7 January 2021

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Regulation of translational initiation during cellular responses to stress

7 January 2021

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0022-2836(02)00234-6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12083523%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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