The DDE recombinases: diverse roles in acquired and innate immunity (Q36682142)

15 August 2017

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title

The DDE recombinases: diverse roles in acquired and innate immunity (English)

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15 August 2017

David H Dreyfus

1

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15 August 2017

1 November 2006

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Annals of Allergy, Asthma & Immunology

15 August 2017

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15 August 2017

97

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15 August 2017

567-76; quiz 576-8, 602

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15 August 2017

5

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Somatic generation of antibody diversity

15 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Evidence suggesting an evolutionary relationship between transposable elements and immune system recombination sequences

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Comparative analysis of invertebrate Tc6 sequences that resemble the vertebrate V(D)J recombination signal sequences (RSS).

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

The V(D)J recombination activating gene, RAG-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

How to keep V(D)J recombination under control

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

The taming of a transposon: V(D)J recombination and the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Inverse transposition by the RAG1 and RAG2 proteins: role reversal of donor and target DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Detection of RAG mutations and prenatal diagnosis in families presenting with either T-B- severe combined immunodeficiency or Omenn's syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

The genetic and biochemical basis of Omenn syndrome

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https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Identical mutations in RAG1 or RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined immune deficiency or Omenn syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Evolution of a T-B- SCID into an Omenn syndrome phenotype following parainfluenza 3 virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

A novel immunodeficiency associated with hypomorphic RAG1 mutations and CMV infection

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Argonaute and RNA--getting into the groove

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Argonaute2 is the catalytic engine of mammalian RNAi

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Crystal structure of Argonaute and its implications for RISC slicer activity

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

RNA silencing: the genome's immune system

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Long-term immune reconstitution in RAG-1-deficient mice treated by retroviral gene therapy: a balance between efficiency and toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Epstein-Barr virus infection of T cells: implications for altered T-lymphocyte activation, repertoire development and autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Peripheral blood lymphocytes express recombination-activating genes 1 and 2 during Epstein-Barr virus-induced infectious mononucleosis

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Preliminary mapping of a putative inhibitor-binding pocket for human immunodeficiency virus type 1 integrase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Large-scale conformational dynamics of the HIV-1 integrase core domain and its catalytic loop mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Effect of HIV integrase inhibitors on the RAG1/2 recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Asymmetric DDE (D35E)-like sequences in the RAG proteins: implications for V(D)J recombination and retroviral pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Omenn syndrome due to ARTEMIS mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Artemis sheds new light on V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

V(D)J recombination: RAG proteins, repair factors, and regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma

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https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

The ATM protein is required for sustained activation of NF-kappaB following DNA damage.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

1 reference

7 January 2021

T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

The scope of receptor editing and its association with autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Role for complement receptors (CD21/CD35) in the regulation of recombination activating gene expression in murine peripheral B cells

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Dual T cell receptor T cells with two defined specificities mediate tumor suppression via both receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: a mechanism for the generation of autoaggressive T cells in the periphery

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Induction of peripheral tolerance in dual TCR T cells: an evidence for non-dominant signaling by one TCR.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Control of genotypic allelic inclusion through TCR surface expression.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Structure, organization, and somatic rearrangement of T cell gamma genes.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

A variant of SCID with specific immune responses and predominance of gamma delta T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Regulation of NKT cell development by SAP, the protein defective in XLP

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Role of DNA-dependent protein kinase in neuronal survival.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

An ancient evolutionary origin of the Rag1/2 gene locus

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Activation of the interferon system by short-interfering RNAs

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Recombining the structures of HIV integrase, RuvC and RNase H.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Aminoglycoside complexation with a DNA.RNA hybrid duplex: the thermodynamics of recognition and inhibition of RNA processing enzymes.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Drug targeting of HIV-1 RNA.DNA hybrid structures: thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

Delivery of double-stranded DNA thioaptamers into HIV-1 infected cells for antiviral activity

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

An RNA external guide sequence ribozyme targeting human interleukin-4 receptor alpha mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

RNA interference as potential therapy--not so fast

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2961083-6

7 January 2021

10.1016/S1081-1206(10)61083-6

Identifiers

DOI

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15 August 2017

1 reference

PubMed ID

17165262