Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche (Q36681962)

15 August 2017

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title

Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche (English)

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15 August 2017

Hofmeister CC

1

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15 August 2017

Zhang J

2

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15 August 2017

Knight KL

3

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15 August 2017

Le P

4

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15 August 2017

Stiff PJ

5

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15 August 2017

language of work or name

English

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publication date

1 January 2007

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Bone Marrow Transplantation

15 August 2017

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15 August 2017

39

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15 August 2017

1

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15 August 2017

11-23

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https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705538

15 August 2017

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Prompt and durable engraftment in two older adult patients with high risk chronic myelogenous leukemia (CML) using ex vivo expanded and unmanipulated unrelated umbilical cord blood

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Clonal heterogeneity in growth kinetics of CD34+CD38- human cord blood cells in vitro is correlated with gene expression pattern and telomere length.

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Homing defect of cultured human hematopoietic cells in the NOD/SCID mouse is mediated by Fas/CD95.

21 January 2018

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Cell cycle activation of hematopoietic progenitor cells increases very late antigen-5-mediated adhesion to fibronectin

21 January 2018

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Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy

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Sustained proliferation, multi-lineage differentiation and maintenance of primitive human haemopoietic cells in NOD/SCID mice transplanted with human cord blood

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Clinical isolation and functional characterization of cord blood CD133+ hematopoietic progenitor cells

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Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity

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Cotransplantation of third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation

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Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice

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Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells

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Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells.

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

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Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex

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The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells

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Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells

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Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.

21 January 2018

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Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells

21 January 2018

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Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation

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21 January 2018

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Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo.

21 January 2018

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Quantitative analysis of DNA demethylation and transcriptional reactivation of the FMR1 gene in fragile X cells treated with 5-azadeoxycytidine

21 January 2018

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Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A.

21 January 2018

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Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents

21 January 2018

1 reference

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Pre-clinical development of cord blood-derived progenitor cell graft expanded ex vivo with cytokines and the polyamine copper chelator tetraethylenepentamine

21 January 2018

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Cellular copper content modulates differentiation and self-renewal in cultures of cord blood-derived CD34+ cells

21 January 2018

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The role of retinoids and retinoic acid receptors in normal hematopoiesis

21 January 2018

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Retinoid signaling regulates primitive (yolk sac) hematopoiesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

All-trans retinoic acid (ATRA) enhances maintenance of primitive human hematopoietic progenitors and skews them towards myeloid differentiation in a stroma-noncontact culture system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

21 January 2018

1 reference

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Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

Clinical use of umbilical cord blood hematopoietic stem cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

Deficient IL-12(p35) gene expression by dendritic cells derived from neonatal monocytes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

Reduced expression of NFAT-associated genes in UCB versus adult CD4+ T lymphocytes during primary stimulation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

Alloantigen priming induces a state of unresponsiveness in human umbilical cord blood T cells

21 January 2018

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Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

21 January 2018

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Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

CD4+ CD25+ FOXP3+ regulatory T cells from human thymus and cord blood suppress antigen-specific T cell responses.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

Formation of a functional thymus initiated by a postnatal epithelial progenitor cell.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

Identification of a novel, human multilymphoid progenitor in cord blood

21 January 2018

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T-cell development made simple

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BMT.1705538

Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions

21 January 2018

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Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

21 January 2018

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Ex vivo expansion, maturation, and activation of umbilical cord blood-derived T lymphocytes with IL-2, IL-12, anti-CD3, and IL-7. Potential for adoptive cellular immunotherapy post-umbilical cord blood transplantation

21 January 2018

1 reference

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Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy

21 January 2018

1 reference

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Increased induction of allogeneic-specific cord blood CD4+CD25+ regulatory T (Treg) cells: a comparative study of naïve and antigenic-specific cord blood Treg cells

21 January 2018

1 reference

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Transplants of Umbilical-Cord Blood or Bone Marrow from Unrelated Donors in Adults with Acute Leukemia

21 January 2018

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

21 January 2018

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Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrow

21 January 2018

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7 January 2021

Comparative study of the in vitro behavior of cord blood subpopulations after short-term cytokine exposure

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7 January 2021

Increased expansion and differentiation of cord blood products using a two-step expansion culture

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7 January 2021

Transplantation of ex vivo expanded cord blood

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7 January 2021

Clinical-scale human umbilical cord blood cell expansion in a novel automated perfusion culture system

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7 January 2021

CD34 positive PBPC expanded ex vivo may not provide durable engraftment following myeloablative chemoradiotherapy regimens

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7 January 2021

Ex vivo expanded cord blood cells provide rapid engraftment in fetal sheep but lack long-term engrafting potential

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7 January 2021

Expression and activation of caspase-3/CPP32 in CD34(+) cord blood cells is linked to apoptosis after growth factor withdrawal

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7 January 2021

Ex vivo expansion of umbilical cord blood (UCB) CD34(+) cells alters the expression and function of alpha 4 beta 1 and alpha 5 beta 1 integrins

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7 January 2021

Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice

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7 January 2021

Distinct hematopoietic stem/progenitor cell populations are responsible for repopulating NOD/SCID mice compared with nonhuman primates

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7 January 2021

Dissociation between stem cell phenotype and NOD/SCID repopulating activity in human peripheral blood CD34(+) cells after ex vivo expansion

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7 January 2021

The rate of marrow recovery and extent of donor engraftment following transplantation of ex vivo-expanded bone marrow cells are independently influenced by the cytokines used for expansion

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7 January 2021

Stem cell factor improves SCID-repopulating activity of human umbilical cord blood-derived hematopoietic stem/progenitor cells in xenotransplanted NOD/SCID mouse model

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7 January 2021

Flt3LP3nduces the ex-vivo amplification of umbilical cord blood committed progenitors and early stem cells in short-term cultures

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7 January 2021

Flt3-ligand induces adhesion of haematopoietic progenitor cells via a very late antigen (VLA)-4- and VLA-5-dependent mechanism

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7 January 2021

Thrombopoietin, flt3, and kit ligands together suppress apoptosis of human mobilized CD34+ cells and recruit primitive CD34+ Thy-1+ cells into rapid division

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7 January 2021

Elevated telomerase activity and minimal telomere loss in cord blood long-term cultures with extensive stem cell replication

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7 January 2021

Quantitative analysis demonstrates expansion of SCID-repopulating cells and increased engraftment capacity in human cord blood following ex vivo culture with human brain endothelial cells

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7 January 2021

Nonexpanded primary lung and bone marrow–derived mesenchymal cells promote the engraftment of umbilical cord blood–derived CD34+ cells in NOD/SCID mice

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7 January 2021

Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells

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7 January 2021

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

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7 January 2021

BMP4 initiates human embryonic stem cell differentiation to trophoblast

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7 January 2021

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

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7 January 2021

Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny

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7 January 2021

Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein

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7 January 2021

Immunity in early life

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7 January 2021

Reduced primary antigen-specific T-cell precursor frequencies in neonates is associated with deficient interleukin-2 production

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7 January 2021

Factors influencing T-lymphopoiesis after allogeneic hematopoietic cell transplantation

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7 January 2021

Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation

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7 January 2021

Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments

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7 January 2021

Molecular characterization of early human T/NK and B-lymphoid progenitor cells in umbilical cord blood

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7 January 2021

Identifiers

DOI

10.1038/SJ.BMT.1705538

1 reference

15 August 2017

1 reference