Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4. (Q39753312)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12748289%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4 (English)

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3 November 2019

10

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3 November 2019

Elisabet Andersson

5

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3 November 2019

author name string

Jon Mar Björnsson

1

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3 November 2019

Nina Larsson

2

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3 November 2019

Ann C M Brun

3

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3 November 2019

Mattias Magnusson

4

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3 November 2019

Patrik Lundström

6

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3 November 2019

Jonas Larsson

7

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3 November 2019

Ewa Repetowska

8

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3 November 2019

Mats Ehinger

9

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3 November 2019

Stefan Karlsson

11

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3 November 2019

language of work or name

English

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publication date

1 June 2003

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Molecular and Cellular Biology

3 November 2019

published in

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3 November 2019

volume

23

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issue

11

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3 November 2019

page(s)

3872-3883

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High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation

3 November 2019

cites work

1 reference

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Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells

22 September 2017

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Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion

22 September 2017

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The HOX homeodomain proteins block CBP histone acetyltransferase activity

22 September 2017

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The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver

22 September 2017

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Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo

22 September 2017

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Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression

22 September 2017

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Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

22 September 2017

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Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2

22 September 2017

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Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases.

22 September 2017

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Disruption of the homeobox gene Hoxb-6 in mice results in increased numbers of early erythrocyte progenitors

22 September 2017

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22 September 2017

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A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations

22 September 2017

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Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development

22 September 2017

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c-myc intron element-binding proteins are required for 1, 25-dihydroxyvitamin D3 regulation of c-myc during HL-60 cell differentiation and the involvement of HOXB4.

22 September 2017

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Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

22 September 2017

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Selectivity, sharing and competitive interactions in the regulation of Hoxb genes

22 September 2017

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Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures

22 September 2017

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Regulation of number and size of digits by posterior Hox genes: A dose-dependent mechanism with potential evolutionary implications

22 September 2017

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Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice

22 September 2017

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HOXD4 and regulation of the group 4 paralog genes

22 September 2017

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Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture

22 September 2017

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Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.

22 September 2017

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Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation

22 September 2017

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Multiplex Cre/lox recombination permits selective site-specific DNA targeting to both a natural and an engineered site in the yeast genome

22 September 2017

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Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

22 September 2017

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22 September 2017

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Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations

22 September 2017

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22 September 2017

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Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed

22 September 2017

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22 September 2017

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22 September 2017

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Hematopoietic progenitor/stem cells immortalized by Lhx2 generate functional hematopoietic cells in vivo

22 September 2017

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Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy

25 September 2017

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Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

25 September 2017

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The retroviral transduction of HOXC4 into human CD34(+) cells induces an in vitro expansion of clonogenic and early progenitors.

25 September 2017

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Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

25 September 2017

1 reference

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Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells

25 September 2017

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Enhanced in vivo regenerative potential of HOXB4-transduced hematopoietic stem cells with regulation of their pool size

17 June 2018

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Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes.

17 June 2018

1 reference

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Hox homeobox genes as regulators of normal and leukemic hematopoiesis

17 June 2018

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Transcription factors, normal myeloid development, and leukemia

17 June 2018

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Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns.

17 June 2018

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HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

17 June 2018

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HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.

20 August 2018

1 reference

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Proliferation of primitive myeloid progenitors can be reversibly induced by HOXA10.

20 August 2018

1 reference

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HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation.

20 August 2018

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Diversification of haematopoietic stem cells to specific lineages.

20 August 2018

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AP-1 complex is effector of Hox-induced cellular proliferation and transformation.

20 August 2018

1 reference

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p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells

20 August 2018

1 reference

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Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene.

20 August 2018

1 reference

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Phenotypic and functional characterization of competitive long-term repopulating hematopoietic stem cells enriched from 5-fluorouracil-treated murine marrow

20 August 2018

1 reference

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Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments

4 November 2018

1 reference

12 December 2020

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1 reference

12 December 2020

Long-term repopulating abilities of enriched fetal liver stem cells measured by competitive repopulation

1 reference

12 December 2020

Hox C cluster genes are dispensable for overall body plan of mouse embryonic development

1 reference

12 December 2020

Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment

1 reference

12 December 2020

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

12 December 2020

Thrombopoietin, kit ligand, and flk2/flt3 ligand together induce increased numbers of primitive hematopoietic progenitors from human CD34+Thy-1+Lin- cells with preserved ability to engraft SCID-hu bone

1 reference

12 December 2020

10.1128/MCB.23.11.3872-3883.2003

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DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12748289%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12748289%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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