The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes (Q36634002)

15 August 2017

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title

The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes (English)

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15 August 2017

David J Rawlings

1

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15 August 2017

Karen Sommer

series ordinal

2

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15 August 2017

Miguel E Moreno-García

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3

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15 August 2017

1 November 2006

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Nature Reviews Immunology

15 August 2017

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15 August 2017

6

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15 August 2017

799-812

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15 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nri1944

15 August 2017

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cites work

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Evolution of innate and adaptive immunity: can we draw a line?

21 January 2018

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Reconstructing immune phylogeny: new perspectives

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Evolution of effectors and receptors of innate immunity

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Phosphorylation of the CARMA1 linker controls NF-kappaB activation

21 January 2018

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Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation

21 January 2018

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PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

21 January 2018

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Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

21 January 2018

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The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

21 January 2018

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Essential function for the kinase TAK1 in innate and adaptive immune responses.

21 January 2018

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The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function.

21 January 2018

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Essential role of TAK1 in thymocyte development and activation.

21 January 2018

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Control of lymphocyte development by nuclear factor-kappaB.

21 January 2018

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B cell antigen receptor signaling 101.

21 January 2018

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Regulation of the phospholipase C-gamma2 pathway in B cells

21 January 2018

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T cell antigen-receptor signal transduction

21 January 2018

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T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes

21 January 2018

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CARMA1, BCL-10 and MALT1 in lymphocyte development and activation.

21 January 2018

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The MAGUK family protein CARD11 is essential for lymphocyte activation

21 January 2018

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Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes

21 January 2018

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Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation

21 January 2018

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Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

21 January 2018

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A requirement for CARMA1 in TCR-induced NF-kappa B activation

21 January 2018

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CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation

21 January 2018

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CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex.

21 January 2018

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Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation

21 January 2018

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CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B

21 January 2018

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Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction

21 January 2018

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Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins

21 January 2018

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Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)

21 January 2018

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Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types

21 January 2018

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Regulation of NF-κB-Dependent Lymphocyte Activation and Development by Paracaspase

21 January 2018

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

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Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

21 January 2018

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CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10

21 January 2018

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CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis

21 January 2018

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The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse

21 January 2018

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CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1

21 January 2018

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Caspase recruitment domain (CARD)-dependent cytoplasmic filaments mediate bcl10-induced NF-kappaB activation

21 January 2018

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Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation

21 January 2018

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Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway

21 January 2018

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Differential Requirement for Malt1 in T and B Cell Antigen Receptor Signaling

21 January 2018

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Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.

21 January 2018

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Structural basis for self-association and receptor recognition of human TRAF2

21 January 2018

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Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry

21 January 2018

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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

21 January 2018

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Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

21 January 2018

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NF-kappaB activation: the I kappaB kinase revealed?

21 January 2018

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Catalysis by a multiprotein IkappaB kinase complex

21 January 2018

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Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

21 January 2018

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Non-traditional functions of ubiquitin and ubiquitin-binding proteins

21 January 2018

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Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

21 January 2018

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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

21 January 2018

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TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages

21 January 2018

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

21 January 2018

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TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

21 January 2018

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Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

21 January 2018

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TAB3, a new binding partner of the protein kinase TAK1

21 January 2018

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TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

21 January 2018

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Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation

21 January 2018

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TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop

21 January 2018

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Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.

21 January 2018

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Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling

21 January 2018

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TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

21 January 2018

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

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The RIP kinases: crucial integrators of cellular stress

21 January 2018

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Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein

21 January 2018

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Antiapoptotic function of apoptosis inhibitor 2-MALT1 fusion protein involved in t(11;18)(q21;q21) mucosa-associated lymphoid tissue lymphoma

21 January 2018

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The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains

21 January 2018

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Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

21 January 2018

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

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Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator

21 January 2018

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

21 January 2018

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Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

21 January 2018

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A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha

21 January 2018

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Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling

21 January 2018

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cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas

21 January 2018

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The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

21 January 2018

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Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling

21 January 2018

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Immunity by ubiquitylation: a reversible process of modification

21 January 2018

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Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation

21 January 2018

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Mature T cells depend on signaling through the IKK complex.

21 January 2018

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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

21 January 2018

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Overexpression of caspase recruitment domain (CARD) membrane-associated guanylate kinase 1 (CARMA1) and CARD9 in primary gastric B-cell lymphoma

21 January 2018

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A loss-of-function RNA interference screen for molecular targets in cancer

21 January 2018

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Delving deeper into MALT lymphoma biology

21 January 2018

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ITAMs versus ITIMs: striking a balance during cell regulation

21 January 2018

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PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation

21 January 2018

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Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

21 January 2018

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The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3

21 January 2018

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Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling

21 January 2018

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CARMA1 is required for Akt-mediated NF-kappaB activation in T cells

21 January 2018

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Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation.

21 January 2018

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Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

21 January 2018

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Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.

21 January 2018

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RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

21 January 2018

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Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

21 January 2018

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Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

21 January 2018

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Ubiquitin signalling in the NF-kappaB pathway

21 January 2018

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

21 January 2018

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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

21 January 2018

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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

21 January 2018

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

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The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

21 January 2018

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

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PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling

21 January 2018

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Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells

31 March 2020

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Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1944

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Dimensions Publication ID

15 August 2017

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