AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease. (Q36608838)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26681807%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease (English)

1 reference

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3 March 2020

0 references

Rafael P Vázquez-Manrique

1

1 reference

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3 March 2020

Karine Cambon

3

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3 March 2020

Nicole Déglon

8

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3 March 2020

Christian Neri

9

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3 March 2020

author name string

Francesca Farina

2

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3 March 2020

María Dolores Sequedo

4

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3 March 2020

Alex J Parker

5

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3 March 2020

José María Millán

6

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3 March 2020

Andreas Weiss

7

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3 March 2020

publication date

17 December 2015

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3 March 2020

published in

Human Molecular Genetics

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3 March 2020

volume

25

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3 March 2020

issue

6

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3 March 2020

page(s)

1043-1058

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describes a project that uses

3 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4764188/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

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Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

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Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease

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Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

30 September 2017

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30 September 2017

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30 September 2017

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

30 September 2017

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30 September 2017

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Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

30 September 2017

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Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans

30 September 2017

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Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease

30 September 2017

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AMPK in Health and Disease

30 September 2017

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30 September 2017

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30 September 2017

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Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease

30 September 2017

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The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior

30 September 2017

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The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor

30 September 2017

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

30 September 2017

1 reference

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Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

30 September 2017

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

30 September 2017

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30 September 2017

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30 September 2017

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

30 September 2017

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Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.

30 September 2017

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30 September 2017

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Role of AMP-activated protein kinase in mechanism of metformin action

30 September 2017

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

30 September 2017

1 reference

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Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus.

30 September 2017

1 reference

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

30 September 2017

1 reference

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AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

30 September 2017

1 reference

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daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

30 September 2017

1 reference

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30 September 2017

1 reference

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The genetics of Caenorhabditis elegans

30 September 2017

1 reference

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Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

30 September 2017

1 reference

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The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

28 June 2018

1 reference

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"Preconditioning" with latrepirdine, an adenosine 5'-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1(G93A) mice.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764188

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764188

Metformin treatment alters memory function in a mouse model of Alzheimer's disease.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764188

AMPK activation ameliorates Alzheimer's disease-like pathology and spatial memory impairment in a streptozotocin-induced Alzheimer's disease model in rats

20 September 2018

1 reference

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Ischemic preconditioning provides neuroprotection by induction of AMP-activated protein kinase-dependent autophagy in a rat model of ischemic stroke.

20 September 2018

1 reference

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TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease

20 September 2018

1 reference

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Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity.

20 September 2018

1 reference

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Role of AMP-activated protein kinase in autophagy and proteasome function

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764188

Metformin therapy in a transgenic mouse model of Huntington's disease.

20 September 2018

1 reference

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CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764188

Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764188

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764188

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764188

Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764188

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764188

20 September 2018

Identifiers

DOI

10.1093/HMG/DDV513

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26681807%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26681807%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26681807%20AND%20SRC:MED&resulttype=core&format=json