The AMPK signalling pathway coordinates cell growth, autophagy and metabolism (Q24616273)

Structure of mammalian AMPK and its regulation by ADP

Europe PubMed Central

title

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism (English)

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Maria M Mihaylova

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Reuben J Shaw

series ordinal

2

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language of work or name

English

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publication date

September 2011

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published in

Nature Cell Biology

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volume

13

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page(s)

1016-23

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issue

9

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cites work

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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AMPK and PPARdelta agonists are exercise mimetics

7 April 2017

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

7 April 2017

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AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

7 April 2017

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7 April 2017

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7 April 2017

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

7 April 2017

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

7 April 2017

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

7 April 2017

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The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase

7 April 2017

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Role of AMP-activated protein kinase in mechanism of metformin action

7 April 2017

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Tor-mediated induction of autophagy via an Apg1 protein kinase complex

7 April 2017

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MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

7 April 2017

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Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion

7 April 2017

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Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila

7 April 2017

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Resveratrol improves health and survival of mice on a high-calorie diet

7 April 2017

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Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p

7 April 2017

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

7 April 2017

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AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation

7 April 2017

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

7 April 2017

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AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

7 April 2017

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Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation

7 April 2017

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SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

7 April 2017

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

7 April 2017

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

7 April 2017

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

7 April 2017

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Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase

7 April 2017

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Autophagy fights disease through cellular self-digestion

7 April 2017

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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

22 April 2017

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Circadian integration of metabolism and energetics

7 April 2017

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Autophagy in mammalian development and differentiation

7 April 2017

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Eaten alive: a history of macroautophagy

7 April 2017

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The role of the Atg1/ULK1 complex in autophagy regulation

7 April 2017

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

7 April 2017

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

7 April 2017

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

7 April 2017

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7 April 2017

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

7 April 2017

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

7 April 2017

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AMP-activated protein kinase: also regulated by ADP?

7 April 2017

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Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype

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Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

27 September 2017

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AMPK regulates circadian rhythms in a tissue- and isoform-specific manner

27 September 2017

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Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity.

27 September 2017

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AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress

27 September 2017

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Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK.

27 September 2017

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AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane

27 September 2017

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Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

27 September 2017

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The LKB1/AMPK polarity pathway

27 September 2017

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Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas

27 September 2017

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Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

27 September 2017

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The association of AMPK with ULK1 regulates autophagy

27 September 2017

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β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK).

27 September 2017

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Primary cilia regulate mTORC1 activity and cell size through Lkb1.

27 September 2017

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Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase

27 September 2017

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AMP-activated protein kinase and its downstream transcriptional pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

27 September 2017

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

27 September 2017

1 reference

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

27 September 2017

1 reference

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Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways

27 September 2017

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27 September 2017

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Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.

27 September 2017

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AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

27 September 2017

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The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy

27 September 2017

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27 September 2017

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AMPK: an emerging drug target for diabetes and the metabolic syndrome

27 September 2017

1 reference

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TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.

27 September 2017

1 reference

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Regulation of LKB1/STRAD localization and function by E-cadherin

27 September 2017

1 reference

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Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

27 September 2017

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Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

27 September 2017

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Hypothalamic CaMKK2 contributes to the regulation of energy balance

27 September 2017

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STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.

27 September 2017

1 reference

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AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus

27 September 2017

1 reference

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SNF1/AMPK pathways in yeast

27 September 2017

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The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor

27 September 2017

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Energy-dependent regulation of cell structure by AMP-activated protein kinase

27 September 2017

1 reference

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LKB1 and AMPK maintain epithelial cell polarity under energetic stress

27 September 2017

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Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase

27 September 2017

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Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling

27 September 2017

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Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase

27 September 2017

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KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC.

27 September 2017

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AMP-activated protein kinase regulates PEPCK gene expression by direct phosphorylation of a novel zinc finger transcription factor

27 September 2017

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AMP-activated protein kinase regulates the assembly of epithelial tight junctions

27 September 2017

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A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

AMP-activated protein kinase as a drug target.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

LKB1-dependent signaling pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Acute and chronic treatment of ob/ob and db/db mice with AICAR decreases blood glucose concentrations.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

AMPK and autophagy get connected.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

AMPK is a direct adenylate charge-regulated protein kinase.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Cell biology. ADaPting to energetic stress.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Transcription. Targeting the core of transcription.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

GSK/Sirtris compounds dogged by assay artifacts

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

A central integrator of transcription networks in plant stress and energy signalling.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249400

Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK-->ERK1/2 pathway

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21892142

12 December 2020

inferred from PubMed ID database lookup

A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21892142

12 December 2020

inferred from PubMed ID database lookup

Neither LKB1 nor AMPK are the direct targets of metformin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21892142

12 December 2020

inferred from PubMed ID database lookup

Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCB2329

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCB2329

1 reference

Dimensions Publication ID

204104

1030314957

0 references

Fatcat ID

release_rhrvukfr2vemjmud4yxv5umveu

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rhrvukfr2vemjmud4yxv5umveu

24 November 2022

mapped directly with Wikidata item

204104

1 reference

1 reference

1 reference