Mitochondria as therapeutic targets for cancer chemotherapy (Q36558028)

14 August 2017

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title

Mitochondria as therapeutic targets for cancer chemotherapy (English)

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14 August 2017

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1

Galluzzi L

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14 August 2017

4

Kroemer G

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14 August 2017

2

Larochette N

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14 August 2017

Zamzami N

3

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PubMed ID

16892093

14 August 2017

language of work or name

English

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publication date

1 August 2006

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14 August 2017

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14 August 2017

25

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14 August 2017

4812-4830

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14 August 2017

34

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209598

14 August 2017

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High frequency of somatic mitochondrial DNA mutations in human thyroid carcinomas and complex I respiratory defect in thyroid cancer cell lines.

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7 January 2021

Ways of dying: multiple pathways to apoptosis.

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7 January 2021

Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor

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7 January 2021

Interleukin 2-Bax: a novel prototype of human chimeric proteins for targeted therapy

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7 January 2021

Targeting the prostate for destruction through a vascular address

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7 January 2021

In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death

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7 January 2021

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection

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7 January 2021

The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

PK11195, a peripheral benzodiazepine receptor ligand, chemosensitizes acute myeloid leukemia cells to relevant therapeutic agents by more than one mechanism

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis

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7 January 2021

Apoptosis-inducing human-origin Fcepsilon-Bak chimeric proteins for targeted elimination of mast cells and basophils: a new approach for allergy treatment

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Inhibition of macroautophagy triggers apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

A large Ca2+-dependent channel formed by recombinant ADP/ATP carrier from Neurospora crassa resembles the mitochondrial permeability transition pore

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Nitric oxide-induced carbonylation of Bcl-2, GAPDH and ANT precedes apoptotic events in insulin-secreting RINm5F cells.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Regulation of cytoplasmic stress granules by apoptosis-inducing factor

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Peripheral benzodiazepine receptors and mitochondrial function

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial apoptosis and the peripheral benzodiazepine receptor: a novel target for viral and pharmacological manipulation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

3,5,3'-triiodothyronine induces mitochondrial permeability transition mediated by reactive oxygen species and membrane protein thiol oxidation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

4,6-Dinitro-o-cresol uncouples oxidative phosphorylation and induces membrane permeability transition in rat liver mitochondria

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

MMDB: Entrez's 3D-structure database.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

VDAC2 inhibits BAK activation and mitochondrial apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

4-hydroxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one induces mitochondrial dysfunction and apoptosis upon its intracellular oxidation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Photodynamic therapy-induced death of HCT 116 cells: Apoptosis with or without Bax expression.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial translocation of cofilin is an early step in apoptosis induction.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Citrinin-induced mitochondrial permeability transition

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Cell death: critical control points

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Palmitate induces apoptosis via a direct effect on mitochondria.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Chemotherapy: targeting the mitochondrial cell death pathway

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Anti-cancer activity of targeted pro-apoptotic peptides

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Akt stimulates aerobic glycolysis in cancer cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

A bifunctional targeted peptide that blocks HER-2 tyrosine kinase and disables mitochondrial function in HER-2-positive carcinoma cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Organelle-specific initiation of cell death pathways

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Sensitization for anticancer drug-induced apoptosis by betulinic Acid

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Lipid microdomains contribute to apoptosis-associated modifications of mitochondria in T cells.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Glutamate interacts with VDAC and modulates opening of the mitochondrial permeability transition pore

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Expression of human ANT2 gene in highly proliferative cells: GRBOX, a new transcriptional element, is involved in the regulation of glycolytic ATP import into mitochondria

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The central executioners of apoptosis: caspases or mitochondria?

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The pathophysiology of mitochondrial cell death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Pharmacological manipulation of cell death: clinical applications in sight?

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

tBID Homooligomerizes in the mitochondrial membrane to induce apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Creation of human tumour cells with defined genetic elements

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-kappaB by inhibiting both its nuclear localization and ability to bind DNA

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Control of the mitochondrial permeability transition pore by high-affinity ADP binding at the ADP/ATP translocase in permeabilized mitochondria

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

N-benzyladriamycin-14-valerate (AD198) induces apoptosis through protein kinase C-delta-induced phosphorylation of phospholipid scramblase 3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

How do Ca2+ and 5-aminolevulinic acid-derived oxyradicals promote injury to isolated mitochondria?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Cell death induced by granzyme C.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition pore

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human B lymphoma cells through mitochondrial damage

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial-generated reactive oxygen species.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The proto-oncogene Bcl-2 and its role in regulating apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Arsenic trioxide, a novel mitochondriotoxic anticancer agent?

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial control of cell death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The Destabilization of Lipid Membranes Induced by the C-terminal Fragment of Caspase 8-cleaved Bid Is Inhibited by the N-terminal Fragment

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Abrogation of the cell death response to oxidative stress by the c-Abl tyrosine kinase inhibitor STI571.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondria permeabilization by a novel polycation peptide BTM-P1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

1 reference

7 January 2021

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Proapoptotic triterpene electrophiles (avicins) form channels in membranes: cholesterol dependence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Cardiolipin provides specificity for targeting of tBid to mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

A novel adenine nucleotide translocase inhibitor, MT-21, induces cytochrome c release by a mitochondrial permeability transition-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Bcl-XL Mutations Suppress Cellular Sensitivity to Antimycin A

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The crystal structure of the mouse apoptosis-inducing factor AIF

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

p53 has a direct apoptogenic role at the mitochondria

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

NADH oxidase activity of mitochondrial apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

High-resolution solution structure of the 18 kDa substrate-binding domain of the mammalian chaperone protein Hsc70

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Reversal of Bcl-2-mediated resistance of the EW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a ligand of the mitochondrial benzodiazepine receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Positively charged ceramide is a potent inducer of mitochondrial permeabilization.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Cytochrome c release from mitochondria proceeds by a two-step process

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Benzoquinone inhibits the voltage-dependent induction of the mitochondrial permeability transition caused by redox-cycling naphthoquinones.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Daphnetoxin interacts with mitochondrial oxidative phosphorylation and induces membrane permeability transition in rat liver

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Fatal liaisons of p53 with Bax and Bak

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial fusion and fission in the control of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

mtDNA mutations increase tumorigenicity in prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The peptide mastoparan is a potent facilitator of the mitochondrial permeability transition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Cytofluorometric quantitation of apoptosis-driven inner mitochondrial membrane permeabilization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

An anti-apoptotic viral protein that recruits Bax to mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Heat-shock protein 70 antagonizes apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Structural basis for the inhibition of caspase-3 by XIAP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Distinct pathways for stimulation of cytochrome c release by etoposide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial hexokinases: guardians of the mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

DNA methylation is required for silencing of ant4, an adenine nucleotide translocase selectively expressed in mouse embryonic stem cells and germ cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Bid, but not Bax, regulates VDAC channels.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Jasmonates: novel anticancer agents acting directly and selectively on human cancer cell mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Alloxan-induced mitochondrial permeability transition triggered by calcium, thiol oxidation, and matrix ATP.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Glycyrrhetinic acid-induced permeability transition in rat liver mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Carbenoxolone induces oxidative stress in liver mitochondria, which is responsible for transition pore opening

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Tumor necrosis factor-related apoptosis-inducing ligand alters mitochondrial membrane lipids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Ion channel activity of the BH3 only Bcl-2 family member, BID.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial creatine kinase in human health and disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Cyclophilin D, a component of the permeability transition-pore, is an apoptosis repressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Transient protection by peripheral benzodiazepine receptors during the early events of ultraviolet light-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Two distinct pathways leading to nuclear apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

MAP-1 is a mitochondrial effector of Bax.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

AIF deficiency compromises oxidative phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Physical interaction of apoptosis-inducing factor with DNA and RNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

On the Origin of Cancer Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Glycogen Synthase Kinase-3β (GSK3β) Binds to and Promotes the Actions of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

A central role for Bid in granzyme B-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Relation between the activities reducing disulfides and the protection against membrane permeability transition in rat liver mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Photochemical destruction of the Bcl-2 oncoprotein during photodynamic therapy with the phthalocyanine photosensitizer Pc 4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

DNA binding is required for the apoptogenic action of apoptosis inducing factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Selective proapoptotic activity of a secreted recombinant antibody/AIF fusion protein in carcinomas overexpressing HER2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Molecular mechanisms of butylated hydroxylanisole-induced toxicity: induction of apoptosis through direct release of cytochrome c

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The voltage-dependent anion channel-1 modulates apoptotic cell death.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Bid acts on the permeability transition pore complex to induce apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Mitochondrial permeability transition in apoptosis and necrosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

The mitochondrial permeability transition.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209598

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209598

1 reference

14 August 2017

1 reference

PubMed ID

16892093