Molecular mechanisms for drug interactions with hERG that cause long QT syndrome. (Q36545039)

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27 December 2019

review article

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title

Molecular mechanisms for drug interactions with hERG that cause long QT syndrome (English)

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27 December 2019

1

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27 December 2019

Mike Sutcliffe

2

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27 December 2019

John S Mitcheson

3

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27 December 2019

author name string

Phillip J Stansfeld

1

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14 August 2017

Michael J Sutcliffe

2

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14 August 2017

John S Mitcheson

3

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14 August 2017

language of work or name

English

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publication date

1 February 2006

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Expert Opinion on Drug Metabolism & Toxicology

27 December 2019

published in

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27 December 2019

volume

2

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27 December 2019

issue

1

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27 December 2019

page(s)

81-94

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HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine

27 December 2019

cites work

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A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.

21 January 2018

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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

21 January 2018

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Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

21 January 2018

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The open pore conformation of potassium channels

21 January 2018

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Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain

21 January 2018

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Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel.

21 January 2018

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Structural and functional role of the extracellular s5-p linker in the HERG potassium channel

21 January 2018

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Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation

21 January 2018

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Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule

21 January 2018

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Energetic optimization of ion conduction rate by the K+ selectivity filter

21 January 2018

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Energetics of ion conduction through the K+ channel.

21 January 2018

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K(+) versus Na(+) ions in a K channel selectivity filter: a simulation study

21 January 2018

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Ion binding affinity in the cavity of the KcsA potassium channel

21 January 2018

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X-ray structure of a voltage-dependent K+ channel

21 January 2018

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A structural basis for drug-induced long QT syndrome

21 January 2018

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Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

21 January 2018

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Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

21 January 2018

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Structural determinants of HERG channel block by clofilium and ibutilide.

21 January 2018

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Physicochemical features of the HERG channel drug binding site

21 January 2018

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Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block

21 January 2018

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Voltage-Dependent Profile of HumanEther-a-go-go-Related Gene Channel Block Is Influenced by a Single Residue in the S6 Transmembrane Domain

21 January 2018

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The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.

21 January 2018

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Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652

21 January 2018

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Drug binding to HERG channels: evidence for a 'non-aromatic' binding site for fluvoxamine

21 January 2018

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Sequence-Function Analysis of the K+-Selective Family of Ion Channels Using a Comprehensive Alignment and the KcsA Channel Structure

21 January 2018

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Crystal structure of the potassium channel KirBac1.1 in the closed state

21 January 2018

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A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution

21 January 2018

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Molecular determinants of dofetilide block of HERG K+ channels.

21 January 2018

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The inward rectification mechanism of the HERG cardiac potassium channel

21 January 2018

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Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels.

21 January 2018

1 reference

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Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

21 January 2018

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The aromatic binding site for tetraethylammonium ion on potassium channels

21 January 2018

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Unique interaction of scorpion toxins with the hERG channel

21 January 2018

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Blockade of human cardiac potassium channel human ether-a-go-go-related gene (HERG) by macrolide antibiotics

21 January 2018

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Novel mechanism associated with an inherited cardiac arrhythmia: defective protein trafficking by the mutant HERG (G601S) potassium channel.

21 January 2018

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Biology of cardiac arrhythmias: ion channel protein trafficking

21 January 2018

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Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects

21 January 2018

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The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations

21 January 2018

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21 January 2018

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Pentamidine-induced long QT syndrome and block of hERG trafficking

21 January 2018

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Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome

21 January 2018

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Pentamidine reduces hERG expression to prolong the QT interval

21 January 2018

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Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes

21 January 2018

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Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels

21 January 2018

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HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk

21 January 2018

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Predicting drug-hERG channel interactions that cause acquired long QT syndrome.

21 January 2018

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QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development

21 January 2018

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Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

21 January 2018

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Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel

21 January 2018

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A model for identifying HERG K+ channel blockers

21 January 2018

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Exploring blocker binding to a homology model of the open hERG K+ channel using docking and molecular dynamics methods

21 January 2018

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Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity

21 January 2018

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Pharmacological rescue of human K(+) channel long-QT2 mutations: human ether-a-go-go-related gene rescue without block

21 January 2018

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

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A two-state homology model of the hERG K+ channel: application to ligand binding

21 January 2018

1 reference

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Voltage sensor of Kv1.2: structural basis of electromechanical coupling

21 January 2018

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The principle of gating charge movement in a voltage-dependent K+ channel

21 January 2018

1 reference

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The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path

21 January 2018

1 reference

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High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656.

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1517/17425255.2.1.81

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16863470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference