Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches (Q42598484)

3 November 2017

title

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches (English)

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3 November 2017

author

Maria Preobrazhenskaya

5

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3 November 2017

Robert A Pearlstein

1

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3 November 2017

Roy J Vaz

2

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3 November 2017

Jiesheng Kang

3

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3 November 2017

Xiao-Liang Chen

4

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3 November 2017

Andrey E Shchekotikhin

6

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3 November 2017

Alexander M Korolev

7

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3 November 2017

Ludmila N Lysenkova

8

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3 November 2017

Olga V Miroshnikova

9

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3 November 2017

James Hendrix

10

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3 November 2017

David Rampe

11

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3 November 2017

language of work or name

English

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publication date

1 May 2003

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Bioorganic & Medicinal Chemistry Letters

3 November 2017

published in

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3 November 2017

volume

13

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3 November 2017

issue

10

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3 November 2017

page(s)

1829-1835

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HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine

3 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

A virtual screening method for prediction of the HERG potassium channel liability of compound libraries

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

High affinity blockade of the HERG cardiac K(+) channel by the neuroleptic pimozide

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

Drug-induced torsade de pointes: from molecular biology to bedside.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

A structural basis for drug-induced long QT syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

Molecular and cellular mechanisms of cardiac arrhythmias

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

Crystal structure and mechanism of a calcium-gated potassium channel

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

The open pore conformation of potassium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900196-3

7 January 2021

10.1016/S0960-894X(03)00196-3

Identifiers

DOI

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3 November 2017

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